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Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies

  • Authors:
    • Dung V. Tran
    • Xuan Quy Luu
    • Huong T.T. Tran
    • Seung-Kwon Myung
  • View Affiliations / Copyright

    Affiliations: Department of International Collaboration and Research, Vietnam National Cancer Hospital, Hanoi 110000, Vietnam, Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi‑do 10408, Republic of Korea, Department of Cancer AI and Digital Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Gyeonggi‑do 10408, Republic of Korea
    Copyright: © Tran et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 10
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    Published online on: November 10, 2023
       https://doi.org/10.3892/ol.2023.14144
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Abstract

Previous cohort studies reported inconsistent findings regarding the association between dietary or supplementary vitamin C intake and lung cancer risk. These associations were investigated by conducting a meta‑analysis of cohort studies. The PubMed and EMBASE databases were utilized, using keywords related to the topic from inception to April 15, 2022. Pooled effect sizes, such as relative risk (RR) or hazard ratio (HR) with 95% confidence intervals (CIs), were calculated using a random‑effects model. A total of 20 cohort studies from 13 articles were included in the final analysis. In a meta‑analysis of all studies, there was no significant association between dietary or supplementary vitamin C intake and lung cancer risk (RR/HR, 0.90; 95% CI, 0.80‑1.01; I2=56.4%; n=20). In the subgroup meta‑analysis by the source of vitamin C, dietary vitamin C intake decreased the risk of lung cancer (RR/HR, 0.82; 95% CI, 0.73‑0.92; I2=42.5%; n=14), whereas there was no association between supplementary vitamin C intake and lung cancer risk (RR/HR, 1.01; 95% CI, 0.84‑1.22; n=4). The present meta‑analysis of cohort studies found that dietary vitamin C intake is beneficial for preventing lung cancer, whereas its supplementary intake does not have a beneficial effect.
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Copy and paste a formatted citation
Spandidos Publications style
Tran DV, Luu XQ, Tran HT and Myung S: Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncol Lett 27: 10, 2024.
APA
Tran, D.V., Luu, X.Q., Tran, H.T., & Myung, S. (2024). Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncology Letters, 27, 10. https://doi.org/10.3892/ol.2023.14144
MLA
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27.1 (2024): 10.
Chicago
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27, no. 1 (2024): 10. https://doi.org/10.3892/ol.2023.14144
Copy and paste a formatted citation
x
Spandidos Publications style
Tran DV, Luu XQ, Tran HT and Myung S: Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncol Lett 27: 10, 2024.
APA
Tran, D.V., Luu, X.Q., Tran, H.T., & Myung, S. (2024). Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies. Oncology Letters, 27, 10. https://doi.org/10.3892/ol.2023.14144
MLA
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27.1 (2024): 10.
Chicago
Tran, D. V., Luu, X. Q., Tran, H. T., Myung, S."Dietary and supplementary vitamin C intake and the risk of lung cancer: A meta‑analysis of cohort studies". Oncology Letters 27, no. 1 (2024): 10. https://doi.org/10.3892/ol.2023.14144
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