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Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis

  • Authors:
    • Lu-Lu Xu
    • Tian-Cheng Cheng
    • Neng-Jun Xiang
    • Peng Chen
    • Zhi-Wei Jiang
    • Xin-Xin Liu
  • View Affiliations / Copyright

    Affiliations: The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Department of General Surgery, Jiangsu Provincial Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 30
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    Published online on: November 22, 2023
       https://doi.org/10.3892/ol.2023.14163
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Abstract

The present study aimed to evaluate the incidence and risk factors of severe low anterior resection syndrome (LARS) in patients with rectal cancer undergoing sphincter‑preserving resection, and to provide the clinical basis and reference for the treatment of rectal cancer and the prevention of LARS. Studies on the incidence and risk factors for severe LARS in patients with rectal cancer undergoing sphincter‑preserving resection were searched using PubMed, Embase, Cochrane Library, Scopus and Web of Science, according to the inclusion and exclusion criteria. After evaluating the study quality and extracting relevant data, RevMan 5.2 and STATA software were used to conduct a meta‑analysis. A total of 12 articles were considered eligible for the present meta‑analysis. Within these articles, there were 3,877 cases of sphincter‑preserving resection for rectal cancer and 1,589 cases of severe LARS; the incidence of severe LARS was 40.99%. The results of the meta‑analysis revealed that sex [female; odds ratio (OR), 6.54; 95% CI, 3.63‑11.76; Z, 6.27; P<0.00001], radiotherapy and chemotherapy (OR, 3.45; 95% CI, 2.29‑5.21; Z, 5.91; P<0.00001), total mesorectal excision (TME; OR, 4.39; 95% CI, 3.32‑5.79; Z, 10.41; P<0.00001), and distance between tumor and anal margin (OR, 2.74; 95% CI, 0.86‑8.72; Z, 1.70; P<0.00001) may be the risk factors for severe LARS.
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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Cheng T, Xiang N, Chen P, Jiang Z and Liu X: Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis. Oncol Lett 27: 30, 2024.
APA
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., & Liu, X. (2024). Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis. Oncology Letters, 27, 30. https://doi.org/10.3892/ol.2023.14163
MLA
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., Liu, X."Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis". Oncology Letters 27.1 (2024): 30.
Chicago
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., Liu, X."Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis". Oncology Letters 27, no. 1 (2024): 30. https://doi.org/10.3892/ol.2023.14163
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Cheng T, Xiang N, Chen P, Jiang Z and Liu X: Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis. Oncol Lett 27: 30, 2024.
APA
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., & Liu, X. (2024). Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis. Oncology Letters, 27, 30. https://doi.org/10.3892/ol.2023.14163
MLA
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., Liu, X."Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis". Oncology Letters 27.1 (2024): 30.
Chicago
Xu, L., Cheng, T., Xiang, N., Chen, P., Jiang, Z., Liu, X."Risk factors for severe low anterior resection syndrome in patients with rectal cancer undergoing sphincter‑preserving resection: A systematic review and meta‑analysis". Oncology Letters 27, no. 1 (2024): 30. https://doi.org/10.3892/ol.2023.14163
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