Open Access

Long‑term survival of a patient with advanced lung cancer treated with targeted therapy and anti‑PD‑1 immunotherapy as multi‑line therapy: A case report

  • Authors:
    • Tianhao Guo
    • Wenjian Zhu
    • Shuoqi Zhao
    • Wenli Qiu
    • Yan Wu
    • Xuan Li
    • Fei Ke
    • Haibo Cheng
  • View Affiliations

  • Published online on: November 22, 2023     https://doi.org/10.3892/ol.2023.14166
  • Article Number: 32
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung cancer is the most common type of cancer worldwide. Lung adenocarcinoma, a type of non‑small cell lung cancer (NSCLC), is a common type of lung cancer. In recent years, immunotherapy has become the primary method of treatment for several solid cancers, including NSCLC. In the present study, the case of a patient with NSCLC following left superior lobectomy is reported. Different systemic therapies failed, such as a pemetrexed + carboplatin regimen, paclitaxel liposome + cisplatin and pembrolizumab, and albumin‑bound paclitaxel + toripalimab, but long‑term survival was achieved following targeted therapy and anti‑programmed cell death protein‑1 (PD‑1) immunotherapy. The patient survived for >4 years following lung cancer progression, which is notably longer than expected for patients with advanced lung cancer. In conclusion, the present case demonstrated the efficacy of targeted therapy and anti‑PD‑1 immunotherapy for the treatment of advanced lung cancer following the occurrence of drug resistance and progressive disease.
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January-2024
Volume 27 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Guo T, Zhu W, Zhao S, Qiu W, Wu Y, Li X, Ke F and Cheng H: Long‑term survival of a patient with advanced lung cancer treated with targeted therapy and anti‑PD‑1 immunotherapy as multi‑line therapy: A case report. Oncol Lett 27: 32, 2024
APA
Guo, T., Zhu, W., Zhao, S., Qiu, W., Wu, Y., Li, X. ... Cheng, H. (2024). Long‑term survival of a patient with advanced lung cancer treated with targeted therapy and anti‑PD‑1 immunotherapy as multi‑line therapy: A case report. Oncology Letters, 27, 32. https://doi.org/10.3892/ol.2023.14166
MLA
Guo, T., Zhu, W., Zhao, S., Qiu, W., Wu, Y., Li, X., Ke, F., Cheng, H."Long‑term survival of a patient with advanced lung cancer treated with targeted therapy and anti‑PD‑1 immunotherapy as multi‑line therapy: A case report". Oncology Letters 27.1 (2024): 32.
Chicago
Guo, T., Zhu, W., Zhao, S., Qiu, W., Wu, Y., Li, X., Ke, F., Cheng, H."Long‑term survival of a patient with advanced lung cancer treated with targeted therapy and anti‑PD‑1 immunotherapy as multi‑line therapy: A case report". Oncology Letters 27, no. 1 (2024): 32. https://doi.org/10.3892/ol.2023.14166