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Article

Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes

  • Authors:
    • Turgay Simsek
    • Merve Gulsen Bal Albayrak
    • Gurler Akpinar
    • Nuh Zafer Canturk
    • Murat Kasap
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Kocaeli University Medical School, 41001 Kocaeli, Turkey, Department of Medical Biology, Kocaeli University Medical School, 41001 Kocaeli, Turkey
  • Article Number: 34
    |
    Published online on: November 23, 2023
       https://doi.org/10.3892/ol.2023.14167
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Abstract

Glycerol‑3‑phosphate dehydrogenase (GPD1) and monoacylglycerol lipase (MAGL) levels are known to be significantly downregulated in both the tissue and serum samples of patients with triple‑negative breast cancer (TNBC), compared with other BC subtypes and healthy controls. As such, the association between GPD1 and MAGL levels and lymph node metastasis was evaluated in the present study. Utilizing western blotting, lymph node protein extracts from metastasized BC subtypes were analyzed and a significant downregulation of GPD1 and MAGL protein expression levels in the lymph node metastases was demonstrated in the TNBC subtype, compared with healthy controls. This finding further highlighted the potential use of these two proteins in early BC onset and metastasis detection.
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Copy and paste a formatted citation
Spandidos Publications style
Simsek T, Bal Albayrak MG, Akpinar G, Canturk NZ and Kasap M: Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes. Oncol Lett 27: 34, 2024.
APA
Simsek, T., Bal Albayrak, M.G., Akpinar, G., Canturk, N.Z., & Kasap, M. (2024). Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes. Oncology Letters, 27, 34. https://doi.org/10.3892/ol.2023.14167
MLA
Simsek, T., Bal Albayrak, M. G., Akpinar, G., Canturk, N. Z., Kasap, M."Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes". Oncology Letters 27.1 (2024): 34.
Chicago
Simsek, T., Bal Albayrak, M. G., Akpinar, G., Canturk, N. Z., Kasap, M."Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes". Oncology Letters 27, no. 1 (2024): 34. https://doi.org/10.3892/ol.2023.14167
Copy and paste a formatted citation
x
Spandidos Publications style
Simsek T, Bal Albayrak MG, Akpinar G, Canturk NZ and Kasap M: Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes. Oncol Lett 27: 34, 2024.
APA
Simsek, T., Bal Albayrak, M.G., Akpinar, G., Canturk, N.Z., & Kasap, M. (2024). Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes. Oncology Letters, 27, 34. https://doi.org/10.3892/ol.2023.14167
MLA
Simsek, T., Bal Albayrak, M. G., Akpinar, G., Canturk, N. Z., Kasap, M."Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes". Oncology Letters 27.1 (2024): 34.
Chicago
Simsek, T., Bal Albayrak, M. G., Akpinar, G., Canturk, N. Z., Kasap, M."Downregulated GPD1 and MAGL protein levels as potential biomarkers for the metastasis of triple‑negative breast tumors to axillary lymph nodes". Oncology Letters 27, no. 1 (2024): 34. https://doi.org/10.3892/ol.2023.14167
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