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Research progress on ferroptosis in gliomas (Review)

  • Authors:
    • Yujie Bo
    • Luyan Mu
    • Zhao Yang
    • Wenhao Li
    • Ming Jin
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Bo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 36
    |
    Published online on: November 27, 2023
       https://doi.org/10.3892/ol.2023.14169
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Abstract

Glioma is the most prevalent type of brain tumor characterized by a poor 5‑year survival rate and a high mortality rate. Malignant gliomas are commonly treated by surgery, chemotherapy and radiotherapy. However, due to toxicity and resistance to chemoradiotherapy, these treatments can be ineffective. Anxiety and depression are highly prevalent in patients with glioma, adversely affecting disease prognosis and posing societal concerns. Ferroptosis is a type of non‑apoptotic, iron‑dependent cell death characterized by the accumulation of lethal reactive oxygen species produced by iron metabolism, and it serves a key role in numerous diseases. Regulation of iron phagocytosis may serve as a therapeutic strategy for the development of novel glioma treatments. The present review discusses the mechanisms underlying the occurrence and regulation of ferroptosis, its role in the genesis and evolution of gliomas, and its association with glioma‑related anxiety and depression. By exploring potential targets for glioma treatment, the present review provides a theoretical basis for the development of novel therapeutic strategies against glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Bo Y, Mu L, Yang Z, Li W and Jin M: Research progress on ferroptosis in gliomas (Review). Oncol Lett 27: 36, 2024.
APA
Bo, Y., Mu, L., Yang, Z., Li, W., & Jin, M. (2024). Research progress on ferroptosis in gliomas (Review). Oncology Letters, 27, 36. https://doi.org/10.3892/ol.2023.14169
MLA
Bo, Y., Mu, L., Yang, Z., Li, W., Jin, M."Research progress on ferroptosis in gliomas (Review)". Oncology Letters 27.1 (2024): 36.
Chicago
Bo, Y., Mu, L., Yang, Z., Li, W., Jin, M."Research progress on ferroptosis in gliomas (Review)". Oncology Letters 27, no. 1 (2024): 36. https://doi.org/10.3892/ol.2023.14169
Copy and paste a formatted citation
x
Spandidos Publications style
Bo Y, Mu L, Yang Z, Li W and Jin M: Research progress on ferroptosis in gliomas (Review). Oncol Lett 27: 36, 2024.
APA
Bo, Y., Mu, L., Yang, Z., Li, W., & Jin, M. (2024). Research progress on ferroptosis in gliomas (Review). Oncology Letters, 27, 36. https://doi.org/10.3892/ol.2023.14169
MLA
Bo, Y., Mu, L., Yang, Z., Li, W., Jin, M."Research progress on ferroptosis in gliomas (Review)". Oncology Letters 27.1 (2024): 36.
Chicago
Bo, Y., Mu, L., Yang, Z., Li, W., Jin, M."Research progress on ferroptosis in gliomas (Review)". Oncology Letters 27, no. 1 (2024): 36. https://doi.org/10.3892/ol.2023.14169
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