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Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature

  • Authors:
    • Liang Xu
    • Shuya Luo
    • Qixin Mao
    • Yufeng Gao
    • Lihua Luo
    • Wei Qu
    • Yali Cao
  • View Affiliations / Copyright

    Affiliations: Prevention and Cure Center of Breast Disease, The Third Hospital of Nanchang City, Nanchang, Jiangxi 330009, P.R. China, Outpatient Department, The Third Hospital of Nanchang City, Nanchang, Jiangxi 330009, P.R. China, Department of Breast Disease, Henan Breast Cancer Center, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan 450002, P.R. China, Department of Pathology, The Third Hospital of Nanchang City, Nanchang, Jiangxi 330009, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 39
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    Published online on: December 1, 2023
       https://doi.org/10.3892/ol.2023.14172
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Abstract

Breast carcinoma arising from a fibroadenoma is an uncommon entity and is frequently detected incidentally during pathological examination or excisional biopsy of a benign breast tumor. Due to only sporadic cases being reported, evidence‑based guidelines are not well‑established to date. The present report describes 16 patients diagnosed with breast carcinoma arising within a fibroadenoma in the Third Hospital of Nanchang (Nanchang, China) between January 2019 and December 2021 and discusses the clinicopathological characteristics, imaging findings and treatment. The age of patients at diagnosis ranged between 19 and 58 years and a well‑defined asymptomatic mass was the most common clinical presentation. Carcinoma occurring in fibroadenoma generally mimics a benign tumor and potential carcinomatous changes may not be detected. Pathologically, carcinoma in situ was the predominant subtype in the present study. Additionally, ductal carcinoma in situ was more common compared with lobular carcinoma in situ in the present case series. Regarding the molecular phenotypes, the majority of cases were categorized as luminal subtype, although other subtypes such as triple‑negative and HER2 positive breast cancer were also identified. In the present study, seven patients were treated with breast‑conserving surgery and nine patients were treated with mastectomy. Sentinel lymph node biopsy was performed in all patients and none exhibited axillary node metastasis. Additionally, six patients underwent radiotherapy and two received chemotherapy. During the follow‑up, all patients were alive and no evidence of disease relapse was observed. In summary, clinicians should be aware of the possibility of carcinoma within a fibroadenoma, which could alter the therapeutical course. Adequate biopsy or excision should be performed in patients with indicators of malignant transformation in a presumed benign breast tumor.
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1 

Basara Akin I and Balci P: Fibroadenomas: A multidisciplinary review of the variants. Clin Imaging. 71:83–100. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Lerwill MF, Lee AHS and Tan PH: Fibroepithelial tumours of the breast-a review. Virchows Arch. 480:45–63. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Feliciano YZ, Freire R, Net J and Yepes M: Ductal and lobular carcinoma in situ arising within an enlarging biopsy proven fibroadenoma. BMJ Case Rep. 14:e2370172021. View Article : Google Scholar : PubMed/NCBI

4 

Brock CM, Harper C and Tyler T: Fibroadenoma containing lobular carcinoma in situ, an unusual finding in a normally benign mass. J Surg Case Rep. 2020:rjaa0592020. View Article : Google Scholar : PubMed/NCBI

5 

Shojaku H, Hori R, Yoshida T, Matsui K, Shimada K, Takayanagi N and Noguchi K: Low-grade ductal carcinoma in situ (DCIS) arising in a fibroadenoma of the breast during 5 years follow-up: A case report. Medicine (Baltimore). 100:e240232021. View Article : Google Scholar : PubMed/NCBI

6 

Krishnamurthy K, Alghamdi S, Gyapong S, Kaplan S and Poppiti RJ: A clinicopathological study of fibroadenomas with epithelial proliferation including lobular carcinoma in-situ, atypical ductal hyperplasia, DCIS and invasive carcinoma. Breast Dis. 38:97–101. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Fukuda M, Nagao K, Nishimura R, Matsuda M, Baba K, Ueno Y, Morinaga H, Omachi H and Hamada T: Carcinoma arising in fibroadenoma of the breast-a case report and review of the literature. Jpn J Surg. 19:593–596. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Wu YT, Wu HK, Chen ST, Chen CJ, Chen DR and Lai HW: Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case. J Surg Case Rep. 2017:rjx0642017. View Article : Google Scholar : PubMed/NCBI

9 

Md Nasir ND, Koh VCY, Cree IA, Ruiz BII, Del Águila J, Armon S, Fox SB, Lakhani SR and Tan PH: Phyllodes tumour evidence gaps mapped from the 5th edition of the WHO classification of tumours of the breast. Histopathology. 82:704–712. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Yamamoto Y, Hayashi Y, Sakaki H and Murakami I: Downregulation of fascin induces collective cell migration in triple-negative breast cancer. Oncol Rep. 50:1502023. View Article : Google Scholar : PubMed/NCBI

11 

Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, Bilous M, Ellis IO, Fitzgibbons P, Hanna W, et al: Human epidermal growth factor receptor 2 testing in breast cancer: American society of clinical oncology/college of American pathologists clinical practice guideline focused update. J Clin Oncol. 36:2105–2122. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Jacobs TW, Gown AM, Yaziji H, Barnes MJ and Schnitt SJ: Comparison of fluorescence in situ hybridization and immunohistochemistry for the evaluation of HER-2/neu in Breast Cancer. J Clin Oncol. 17:1974–1982. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Wu YT, Chen ST, Chen CJ, Kuo YL, Tseng LM, Chen DR, Kuo SJ and Lai HW: Breast cancer arising within fibroadenoma: Collective analysis of case reports in the literature and hints on treatment policy. World J Surg Oncol. 12:3352014. View Article : Google Scholar : PubMed/NCBI

14 

Giuliano AE, Connolly JL, Edge SB, Mittendorf EA, Rugo HS, Solin LJ, Weaver DL, Winchester DJ and Hortobagyi GN: Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J Clin. 67:290–303. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Spak DA, Plaxco JS, Santiago L, Dryden MJ and Dogan BE: BI-RADS ® fifth edition: A summary of changes. Diagn Interv Imaging. 98:179–190. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Shiino S, Yoshida M, Tokura M, Watase C, Murata T, Jimbo K, Takayama S, Suto A, Satomi K, Miyagi Maeshima A, et al: Locally advanced triple negative breast cancer arising from fibroadenoma with complete response to neoadjuvant chemotherapy: A case report. Int J Surg Case Rep. 68:234–238. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Razakanaivo M, Rakotoarivo T, Andrianandrasana NO and Rafaramino F: Breast Carcinoma Arising in Fibroadenoma in a 15-Year-Old Girl; Diagnosis and Treatment Challenge. J Cancer Ther. 13:615–620. 2022. View Article : Google Scholar

18 

Ni XH, An R, Shi QW and Wang CL: Low-Grade ductal carcinoma in situ within a fibroadenoma of the breast: A rare case report and review of the literature. Onco Targets Ther. 16:399–406. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Paluch-Shimon S, Cardoso F, Partridge AH, Abulkhair O, Azim HA, Bianchi-Micheli G, Cardoso MJ, Curigliano G, Gelmon KA, Gentilini O, et al: ESO-ESMO fifth International consensus guidelines for breast cancer in young women (BCY5). Ann Oncol. 33:1097–1118. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Ren Y, Li P and Yang Y: Imaging findings of ductal carcinoma in situ arising within fibroadenoma. Breast J. 26:1037–1038. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Tagliati C, Lanni G, Cerimele F, Di Martino A, Calamita V, Lucidi Pressanti G, Mingliang Y, Giuseppetti GM, Argalia G and Giovagnoni A: Low diffusion level within a fibroadenoma as the sole sign of ductal carcinoma in situ: A case report. Breast Dis. 40:283–286. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Saimura M, Koga K, Anan K, Mitsuyama S and Tamiya S: Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 25:470–478. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Hayes BD and Quinn CM: Microinvasive lobular carcinoma arising in a fibroadenoma. Int J Surg Pathol. 21:419–421. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Seow DYB, Tay TKY and Tan PH: Fibroepithelial lesions of the breast: A review of recurring diagnostic issues. Semin Diagn Pathol. 39:333–343. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Diaz NM, Palmer JO and McDivitt RW: Carcinoma arising within fibroadenomas of the breast. A clinicopathologic study of 105 patients. Am J Clin Pathol. 95:614–622. 1991. View Article : Google Scholar : PubMed/NCBI

26 

Hammood ZD, Mohammed SH, Abdulla BA, Omar SS, Naqar S, Salih AM and Kakamad FH: Ductal carcinoma in situ arising from fibroadenoma; a rare case with review of literature. Ann Med Surg (Lond). 75:1034492022.PubMed/NCBI

27 

Ma XL, Kang L, Li BJ, He CN and Zhao HF: Invasive ductal carcinoma displayed ‘basal-like’ feature arising within a breast fibroadenoma. Breast J. 22:695–696. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Fujimoto A, Matsuura K, Kawasaki T, Ichinose Y, Nukui A, Hiratsuka M, Asano A, Shimada H, Osaki A and Saeki T: Early HER2-positive breast cancer arising from a fibroadenoma: A case report. Oxf Med Case Reports. 2021:omab0832021. View Article : Google Scholar : PubMed/NCBI

29 

Miller-Ocuin JL, Howard-McNatt M, Levine EA and Chiba A: Is sentinel lymph node biopsy necessary for ductal carcinoma in situ patients undergoing mastectomy? Am Surg. 86:955–957. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, et al: Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3–07/TROG 07.01): A randomised, factorial, multicentre, open-label, phase 3 study. Lancet. 400:431–440. 2022. View Article : Google Scholar : PubMed/NCBI

31 

Yang L, Shen M, Qiu Y, Tang T and Bu H: Molecular subtyping reveals uniqueness of prognosis in breast ductal carcinoma in situ patients with lumpectomy. Breast. 64:1–6. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Wu J, Sun KW, Mo QP, Yang ZR, Chen Y and Zhong MC: Preoperational diagnosis and management of breast ductal carcinoma in situ arising within fibroadenoma: Two case reports. World J Clin Cases. 10:3496–3504. 2022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Luo S, Mao Q, Gao Y, Luo L, Qu W and Cao Y: Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature. Oncol Lett 27: 39, 2024.
APA
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., & Cao, Y. (2024). Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature. Oncology Letters, 27, 39. https://doi.org/10.3892/ol.2023.14172
MLA
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., Cao, Y."Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature". Oncology Letters 27.1 (2024): 39.
Chicago
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., Cao, Y."Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature". Oncology Letters 27, no. 1 (2024): 39. https://doi.org/10.3892/ol.2023.14172
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Luo S, Mao Q, Gao Y, Luo L, Qu W and Cao Y: Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature. Oncol Lett 27: 39, 2024.
APA
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., & Cao, Y. (2024). Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature. Oncology Letters, 27, 39. https://doi.org/10.3892/ol.2023.14172
MLA
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., Cao, Y."Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature". Oncology Letters 27.1 (2024): 39.
Chicago
Xu, L., Luo, S., Mao, Q., Gao, Y., Luo, L., Qu, W., Cao, Y."Breast carcinoma arising in a fibroadenoma: A case series of 16 patients and review of the literature". Oncology Letters 27, no. 1 (2024): 39. https://doi.org/10.3892/ol.2023.14172
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