A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report

Jiang,Hongyan; Liu,Haijun; Zhao,Linwei; Yang,Ling; Zhao,Yunfei

doi:10.3892/ol.2023.14174

January-2024 Volume 27 Issue 1

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January-2024 Volume 27 Issue 1

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Case Report Open Access

A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report

Authors:
- Hongyan Jiang
- Haijun Liu
- Linwei Zhao
- Ling Yang
- Yunfei Zhao
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Affiliations: Department of Pathology, Suining Central Hospital, Suining, Sichuan 629000, P.R. China, Department of Ultrasound, Suining Central Hospital, Suining, Sichuan 629000, P.R. China, Department of Radiology and Imaging, Suining Central Hospital, Suining, Sichuan 629000, P.R. China

Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 40
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Published online on: December 4, 2023

https://doi.org/10.3892/ol.2023.14174
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Abstract

Primary cardiac lymphomas display a low frequency, sudden onset, swift progression of illness and elevated mortality rates. The current study presents a unique instance of primary cardiac diffuse large B‑cell lymphoma and examines its clinical manifestations, pathological characteristics and differential diagnosis. A 64‑year‑old male patient sought medical attention due to cardiac debility and exertional dyspnea persisting for >10 days. Chest enhanced computed tomography revealed a moderately enhancing irregular mass in the ventricular area, exhibiting limited demarcation from the pericardium and left atrium, accompanied by irregular thickening of the interventricular septum. The postoperative specimen showed the presence of yellow fish‑like tumor tissue. Immunohistochemical analysis revealed the presence of lymphocytes positive for CD20, BCL‑2, BCL‑6, c‑Myc‑binding protein, mutated melanoma‑associated antigen 1 and CD79a, along with a high Ki‑67 proliferation index of 80%. Conversely, CD10, CD30, CD3, pan cytokeratin, cyclin D1, desmin and vimentin marker results were found to be negative. Additionally, in situ hybridization demonstrated a lack of Epstein‑Barr virus‑encoded small RNA expression. The present case report emphasizes the significance of conducting a thorough analysis of the clinical manifestations of diffuse large B‑cell lymphoma to assist clinicians in establishing a diagnosis and determining an effective treatment approach, thereby enhancing the patient's prognosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A rare presentation of primary cardiac diffuse large B‑cell lymphoma: A case report

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