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Case Report Open Access

Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review

  • Authors:
    • Xiaohui Ge
    • Yu Yang
    • Wenyan Wang
    • Lei Tian
    • Ge Zhang
    • Zhesen Tian
    • Xiaoying Xue
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Ge et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 48
    |
    Published online on: December 7, 2023
       https://doi.org/10.3892/ol.2023.14181
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Abstract

H3K27M‑mutant diffuse midline glioma (DMG) is a type of high‑grade glial tumor, which occurs in the midline structure and develops mostly in children. Extraneural metastases (ENM) are exceedingly rare in patients with H3K27M‑mutant DMG. A 9‑year‑old male patient presented with a headache, nausea and vomiting. Following magnetic resonance imaging and immunohistochemical molecular testing examination, the patient was diagnosed with H3K27M‑mutant DMG and received chemoradiotherapy plus five cycles of chemotherapy with temozolomide intermittently as an adjuvant therapy. The treatment resulted in a slight reduction of the tumor volume. However, 2 months later, the patient was admitted to hospital with complaints of drooping of the mouth, and waist and back pain. Magnetic resonance imaging and positron‑emission tomography‑computed tomography revealed an unusual presentation with multiple vertebral metastases and craniospinal leptomeningeal dissemination. Following discussion between the members of a multidisciplinary medical team, the patient underwent one cycle of chemotherapy with cyclophosphamide, vincristine and cisplatin. However, the condition did not improve and the patient died 4 weeks after the diagnosis of ENM. The mechanisms underlying the development of these rare metastases remain unclear. The present case report provides insights into the clinical characteristics and potential metastasis mechanisms of this aggressive disease and may help to elucidate new pathways for the management of ENM.
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1 

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P and Ellison DW: The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary. Acta Neuropathol. 131:803–820. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR, Bjerke L, Clarke M, Vinci M, Nandhabalan M, et al: integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell. 32:520–537.e5. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Ostrom QT, Price M, Ryan K, Edelson J, Neff C, Cioffi G, Waite KA, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Pediatric brain tumor foundation childhood and adolescent primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol. 24 (Suppl 3):iii1–1iii38. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Hamilton JD, Rapp M, Schneiderhan T, Sabel M, Hayman A, Scherer A, Kröpil P, Budach W, Gerber P, Kretschmar U, et al: Glioblastoma multiforme metastasis outside the CNS: Three case reports and possible mechanisms of escape. J Clin Oncol. 32:e80–e84. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Beauchesne P: Extra-neural metastases of malignant gliomas: Myth or reality? Cancers (Basel). 3:461–477. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Stephens S, Tollesson G, Robertson T and Campbell R: Diffuse midline glioma metastasis to the peritoneal cavity via ventriculo-peritoneal shunt: Case report and review of literature. J Clin Neurosci. 67:288–293. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Bhatt NS, Houser K, Belongia M, Ellison DW, Foy A, Jarzembowski J, Kelly T, Maheshwari M, Suchi M and Knipstein J: Diffuse midline glioma with osseous metastases at diagnosis: A case report. J Pediatr Hematol Oncol. 42:e673–e676. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Handis C, Tanrıkulu B, Danyeli AE and Özek MM: Spinal intramedullary H3K27M mutant glioma with vertebral metastasis: A case report. Childs Nerv Syst. 37:3933–3937. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Lazow MA, Leach JL, Trout AT, Breneman JC, Fouladi M and Fuller C: Extraneural metastases of diffuse midline glioma, H3 K27M-Mutant at diagnosis: Case report, review of the literature, and identifying targetable alterations. J Pediatr Hematol Oncol. 44:e597–e604. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Mohiuddin S, Maraka S, Usman Baig M, Gupta S, Muzzafar T, Valyi-Nagy T, Lindsay H, Moody K, Razvi S, Paulino A, et al: Case series of diffuse extraneural metastasis in H3F3A mutant high-grade gliomas: Clinical, molecular phenotype and literature review. J Clin Neurosci. 89:405–411. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Chukwueke UN and Wen PY: Use of the Response Assessment in Neuro-Oncology (RANO) criteria in clinical trials and clinical practice. CNS Oncol. 8:CNS282019. View Article : Google Scholar : PubMed/NCBI

12 

Yi S, Choi S, Shin DA, Kim DS, Choi J, Ha Y, Kim KN, Suh CO, Chang JH, Kim SH and Yoon DH: Impact of H3.3 K27M mutation on prognosis and survival of grade IV spinal cord glioma on the basis of New 2016 World Health Organization classification of the central nervous system. Neurosurgery. 84:1072–1081. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Karremann M, Gielen GH, Hoffmann M, Wiese M, Colditz N, Warmuth-Metz M, Bison B, Claviez A, van Vuurden DG, von Bueren AO, et al: Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol. 20:123–131. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, et al: Brain tumor epidemiology: Consensus from the Brain tumor epidemiology consortium. Cancer. 113 (7 Suppl):S1953–S1968. 2008. View Article : Google Scholar

15 

Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2008–2012. Neuro Oncol. 17 (Suppl 4):iv1–1iv62. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Jones C and Baker SJ: Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer. 14:10.1038/nrc3811. 2014. View Article : Google Scholar

17 

Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, et al: Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 44:251–253. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lu VM, Alvi MA, McDonald KL and Daniels DJ: Impact of the H3K27M mutation on survival in pediatric high-grade glioma: A systematic review and meta-analysis. J Neurosurg Pediatr. 23:308–316. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Navarro RE, Golub D, Hill T, McQuinn MW, William C, Zagzag D and Hidalgo ET: Pediatric midline H3K27M-mutant tumor with disseminated leptomeningeal disease and glioneuronal features: Case report and literature review. Childs Nerv Syst. 37:2347–2356. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Wang Y, Feng LL, Ji PG, Liu JH, Guo SC, Zhai YL, Sankey EW, Wang Y, Xue YR, Wang N, et al: Clinical features and molecular markers on diffuse midline gliomas With H3K27M Mutations: A 43 cases retrospective cohort study. Front Oncol. 10:6025532020. View Article : Google Scholar : PubMed/NCBI

21 

Gamis AS, Egelhoff J, Roloson G, Young J, Woods GM, Newman R and Freeman AI: Diffuse bony metastases at presentation in a child with glioblastoma multiforme. A case report. Cancer. 66:180–184. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Beauchesne P, Soler C and Mosnier JF: Diffuse vertebral body metastasis from a glioblastoma multiforme: A technetium-99m Sestamibi single-photon emission computerized tomography study. J Neurosurg. 93:887–890. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Seoane J and De Mattos-Arruda L: Escaping out of the brain. Cancer Discov. 4:1259–1261. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Piccirilli M, Brunetto GM, Rocchi G, Giangaspero F and Salvati M: Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patients. Clinico-pathological remarks on our series of seven cases and critical review of the literature. Tumori. 94:40–51. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Bernstein JJ and Woodard CA: Glioblastoma cells do not intravasate into blood vessels. Neurosurgery. 36:124–132; discussion 132. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Goodwin CR, Liang L, Abu-Bonsrah N, Hdeib A, Elder BD, Kosztowski T, Bettegowda C, Laterra J, Burger P and Sciubba DM: Extraneural glioblastoma multiforme vertebral metastasis. World Neurosurg. 89:578–582.e3. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Smith HL, Wadhwani N and Horbinski C: Major Features of the 2021 WHO Classification of CNS Tumors. Neurotherapeutics. 19:1691–1704. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Li ZG, Zheng MY, Zhao Q, Liu K, Du JX and Zhang SW: Solitary vertebral metastatic glioblastoma in the absence of primary brain tumor relapse: A case report and literature review. BMC Med Imaging. 20:892020. View Article : Google Scholar : PubMed/NCBI

29 

Zhang W, Cai YY, Wang XL, Wang XX, Li Y, Han GY, Chu YJ, Zhang YX and Hao FR: Bone metastases of glioblastoma: A case report and review of the literature. Front Oncol. 11:7054552021. View Article : Google Scholar : PubMed/NCBI

30 

Jiang H, Yang K, Ren X, Cui Y, Li M, Lei Y and Lin S: Diffuse midline glioma with H3 K27M mutation: A comparison integrating the clinical, radiological, and molecular features between adult and pediatric patients. Neuro Oncol. 22:e1–1e9. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Long W, Yi Y, Chen S, Cao Q, Zhao W and Liu Q: Potential new therapies for pediatric diffuse intrinsic pontine glioma. Front Pharmacol. 8:4952017. View Article : Google Scholar : PubMed/NCBI

32 

Ramaswamy V, Remke M and Taylor MD: An epigenetic therapy for diffuse intrinsic pontine gliomas. Nat Med. 20:1378–1379. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Wiese M, Schill F, Sturm D, Pfister S, Hulleman E, Johnsen SA and Kramm CM: No significant cytotoxic effect of the EZH2 inhibitor tazemetostat (EPZ-6438) on pediatric glioma cells with wildtype histone 3 or mutated histone 3.3. Klin Padiatr. 228:113–117. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Yang G, Fang Y, Zhou M, Li W, Dong D, Chen J, Da Y, Wang K, Li X, Zhang X, et al: Case report: The effective response to pembrolizumab in combination with bevacizumab in the treatment of a recurrent glioblastoma with multiple extracranial metastases. Front Oncol. 12:9489332022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ge X, Yang Y, Wang W, Tian L, Zhang G, Tian Z and Xue X: Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review. Oncol Lett 27: 48, 2024.
APA
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., & Xue, X. (2024). Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review. Oncology Letters, 27, 48. https://doi.org/10.3892/ol.2023.14181
MLA
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., Xue, X."Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review". Oncology Letters 27.2 (2024): 48.
Chicago
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., Xue, X."Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review". Oncology Letters 27, no. 2 (2024): 48. https://doi.org/10.3892/ol.2023.14181
Copy and paste a formatted citation
x
Spandidos Publications style
Ge X, Yang Y, Wang W, Tian L, Zhang G, Tian Z and Xue X: Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review. Oncol Lett 27: 48, 2024.
APA
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., & Xue, X. (2024). Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review. Oncology Letters, 27, 48. https://doi.org/10.3892/ol.2023.14181
MLA
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., Xue, X."Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review". Oncology Letters 27.2 (2024): 48.
Chicago
Ge, X., Yang, Y., Wang, W., Tian, L., Zhang, G., Tian, Z., Xue, X."Pediatric H3K27M‑mutant diffuse midline glioma with vertebral metastasis: A case report and literature review". Oncology Letters 27, no. 2 (2024): 48. https://doi.org/10.3892/ol.2023.14181
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