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Role of prognostic gene DKK1 in oral squamous cell carcinoma

  • Authors:
    • Yujiao Liu
    • Congcong Wei
    • Song Wang
    • Shuxin Ding
    • Yanan Li
    • Yongguo Li
    • Dongping Zhang
    • Guoxiong Zhu
    • Zhen Meng
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University and Shandong Provincial Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250000, P.R. China, Department of Stomatology & Precision Biomedical Laboratory, Liaocheng People's Hospital, Liaocheng University, Liaocheng, Shandong 252000, P.R. China, School of Stomatology, Weifang Medical University, Weifang, Shandong 261000, P.R. China, Biomedical Laboratory, Medical School of Liaocheng University, Liaocheng, Shandong 252000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: December 12, 2023
       https://doi.org/10.3892/ol.2023.14184
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Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers and therapeutic targets for OSCC. Bioinformatics screening of differentially expressed genes in OSCC was performed based on data from The Cancer Genome Atlas and Gene Expression Omnibus databases. Dickkopf Wnt signaling pathway inhibitor 1 (DKK1) was identified to be associated with survival, tumor immunity and DNA repair in OSCC. Furthermore, the effects of DKK1 were evaluated by the knockdown of DKK1 in two OSCC cell lines. The proliferation, clonogenicity, migration and invasion of the cells were assessed in vitro using Cell Counting Kit‑8, colony formation, wound healing and Transwell assays, respectively, and were found to be inhibited by DKK1 knockdown. The present study suggests that DKK1 may be used in the prognosis of patients with OSCC and that targeting DKK1 is a potential strategy for OSCC therapy.
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View References

1 

Zibelman M and Mehra R: Overview of current treatment options and investigational targeted therapies for locally advanced squamous cell carcinoma of the head and neck. Am J Clin Oncol. 39:396–406. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2022. CA Cancer J Clin. 72:7–33. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Jayanthi P, Varun BR and Selvaraj J: Epithelial-mesenchymal transition in oral squamous cell carcinoma: An insight into molecular mechanisms and clinical implications. J Oral Maxillofac Pathol. 24:1892020. View Article : Google Scholar : PubMed/NCBI

4 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

5 

Thomson PJ: Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. J Oral Pathol Med. 47:803–807. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Zaid KW, Nhar BM, Ghadeer Alanazi SM, Murad R, Domani A and Alhafi AJ: Lack of effects of recombinant human bone morphogenetic Protein2 on angiogenesis in oral squamous cell carcinoma induced in the syrian hamster cheek pouch. Asian Pac J Cancer Prev. 17:3527–3531. 2016. View Article : Google Scholar : PubMed/NCBI

7 

D'Silva NJ, Perez-Pacheco C and Schmitd LB: The 3D's of neural phenotypes in oral cancer: Distance, diameter, and density. Adv Biol (Weinh). 7:e22001882023. View Article : Google Scholar : PubMed/NCBI

8 

Torres-Ferrús M, Ursitti F, Alpuente A, Brunello F, Chiappino D, de Vries T, Di Marco S, Ferlisi S, Guerritore L, Gonzalez-Garcia N, et al: From transformation to chronification of migraine: Pathophysiological and clinical aspects. J Headache Pain. 21:422020. View Article : Google Scholar : PubMed/NCBI

9 

Serafini MS, Lopez-Perez L, Fico G, Licitra L, De Cecco L and Resteghini C: Transcriptomics and Epigenomics in head and neck cancer: Available repositories and molecular signatures. Cancers Head Neck. 5:22020. View Article : Google Scholar : PubMed/NCBI

10 

Hede K: Superhighway or blind alley? The cancer genome atlas releases first results. J Natl Cancer Inst. 100:1566–1569. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Fu X, Cheng S, Wang W, Shi O, Gao F, Li Y and Wang Q: TCGA dataset screening for genes implicated in endometrial cancer using RNA-seq profiling. Cancer Genet. 254–255. 40–47. 2021.

12 

Gene Ontology Consortium: The gene ontology resource: Enriching a GOld mine. Nucleic Acids Res. 49(D1): D325–D334. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Liu M, Yang F and Xu Y: Identification of potential drug therapy for dermatofibrosarcoma protuberans with bioinformatics and deep learning technology. Curr Comput Aided Drug Des. 18:393–405. 2022. View Article : Google Scholar : PubMed/NCBI

14 

Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN and Dermody JJ: Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet. 154:27–35. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Sheu JJ, Lee CC, Hua CH, Li CI, Lai MT, Lee SC, Cheng J, Chen CM, Chan C, Chao SC, et al: LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling. Oncogene. 33:1375–1384. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Shen Y, Dong S, Liu J, Zhang L, Zhang J, Zhou H and Dong W: Identification of potential biomarkers for thyroid cancer using bioinformatics strategy: A study based on GEO datasets. Biomed Res Int. 2020:97104212020. View Article : Google Scholar : PubMed/NCBI

18 

Wooller SK, Benstead-Hume G, Chen X, Ali Y and Pearl FMG: Bioinformatics in translational drug discovery. Biosci Rep. 37:BSR201601802017. View Article : Google Scholar : PubMed/NCBI

19 

Ogoshi K, Kasamatsu A, Iyoda M, Sakuma K, Yamatoji M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H and Uzawa K: Dickkopf-1 in human oral cancer. Int J Oncol. 39:329–336. 2011.PubMed/NCBI

20 

Wang Z, Wang J, Chen Z, Wang K and Shi L: MicroRNA-1-3p inhibits the proliferation and migration of oral squamous cell carcinoma cells by targeting DKK1. Biochem Cell Biol. 96:355–364. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Huo Q, Xu C, Shao Y, Yu Q, Huang L, Liu Y and Bao H: Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway. Int J Biol Sci. 17:574–588. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Chi C, Li M, Hou W, Chen Y, Zhang Y and Chen J: Long noncoding RNA SNHG7 activates Wnt/β-catenin signaling pathway in cervical cancer cells by epigenetically silencing DKK1. Cancer Biother Radiopharm. 35:329–337. 2020.PubMed/NCBI

23 

Sun YS, Zhao Z, Yang ZN, Xu F, Lu HJ, Zhu ZY, Shi W, Jiang J, Yao PP and Zhu HP: Risk factors and preventions of breast cancer. Int J Biol Sci. 13:1387–1397. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Niu J, Li XM, Wang X, Liang C, Zhang YD, Li HY, Liu FY, Sun H, Xie SQ and Fang D: DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway. Cancer Cell Int. 19:1682019. View Article : Google Scholar : PubMed/NCBI

25 

Goetz JG, Minguet S, Navarro-Lérida I, Lazcano JJ, Samaniego R, Calvo E, Tello M, Osteso-Ibáñez T, Pellinen T, Echarri A, et al: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell. 146:148–163. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, et al: Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment. Nat Commun. 14:46002023. View Article : Google Scholar : PubMed/NCBI

27 

Luo G, Zhang L, Wu W, Zhang L, Lin J, Shi H, Wu X, Yu Y, Qiu W, Chen J, et al: Upregulation of ubiquitin carboxy-terminal hydrolase 47 (USP47) in papillary thyroid carcinoma ex vivo and reduction of tumor cell malignant behaviors after USP47 knockdown by stabilizing SATB1 expression in vitro. Oncol Lett. 26:3702023.PubMed/NCBI

28 

Zheng W, Qian C, Tang Y, Yang C, Zhou Y, Shen P, Chen W, Yu S, Wei Z, Wang A, et al: Manipulation of the crosstalk between tumor angiogenesis and immunosuppression in the tumor microenvironment: Insight into the combination therapy of anti-angiogenesis and immune checkpoint blockade. Front Immunol. 13:10353232022. View Article : Google Scholar : PubMed/NCBI

29 

Johnson A, Townsend M and O'Neill K: Tumor microenvironment immunosuppression: A roadblock to CAR T-cell advancement in solid tumors. Cells. 11:36262022. View Article : Google Scholar : PubMed/NCBI

30 

Suresh K, Naidoo J, Lin CT and Danoff S: Immune checkpoint immunotherapy for non-small cell lung cancer: Benefits and pulmonary toxicities. Chest. 154:1416–1423. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Betella I, Turbitt WJ, Szul T, Wu B, Martinez A, Katre A, Wall JA, Norian L, Birrer MJ and Arend R: Wnt signaling modulator DKK1 as an immunotherapeutic target in ovarian cancer. Gynecol Oncol. 157:765–774. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Q, Zhao M, Lin S, Han Q, Ye H, Peng F and Li L: Prediction of prognosis and immunotherapy response in lung adenocarcinoma based on CD79A, DKK1 and VEGFC. Heliyon. 9:e185032023. View Article : Google Scholar : PubMed/NCBI

33 

Arend R, Dholakia J, Castro C, Matulonis U, Hamilton E, Jackson CG, LyBarger K, Goodman HM, Duska LR, Mahdi H, et al: DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma. Gynecol Oncol. 172:82–91. 2023. View Article : Google Scholar : PubMed/NCBI

34 

Chu HY, Chen Z, Wang L, Zhang ZK, Tan X, Liu S, Zhang BT, Lu A, Yu Y and Zhang G: Dickkopf-1: A promising target for cancer immunotherapy. Front Immunol. 12:6580972021. View Article : Google Scholar : PubMed/NCBI

35 

Wall JA, Klempner SJ and Arend RC: The anti-DKK1 antibody DKN-01 as an immunomodulatory combination partner for the treatment of cancer. Expert Opin Investig Drugs. 29:639–644. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Phillips C, Bhamra I, Eagle C, Flanagan E, Armer R, Jones CD, Bingham M, Calcraft P, Edmenson Cook A, Thompson B and Woodcock SA: The Wnt pathway inhibitor RXC004 blocks tumor growth and reverses immune evasion in Wnt ligand-dependent cancer models. Cancer Res Commun. 2:914–928. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Lyu H, Zhang J, Wei Q, Huang Y, Zhang R, Xiao S, Guo D, Chen XZ, Zhou C and Tang J: Identification of Wnt/β-catenin- and autophagy-related lncRNA signature for predicting immune efficacy in pancreatic adenocarcinoma. Biology (Basel). 12:3192023.PubMed/NCBI

38 

Muto S, Enta A, Maruya Y, Inomata S, Yamaguchi H, Mine H, Takagi H, Ozaki Y, Watanabe M, Inoue T, et al: Wnt/β-catenin signaling and resistance to immune checkpoint inhibitors: From non-small-cell lung cancer to other cancers. Biomedicines. 11:1902023. View Article : Google Scholar : PubMed/NCBI

39 

D'Souza LC, Shekher A, Challagundla KB, Sharma A and Gupta SC: Reprogramming of glycolysis by chemical carcinogens during tumor development. Semin Cancer Biol. 87:127–136. 2022. View Article : Google Scholar : PubMed/NCBI

40 

Taieb J, Svrcek M, Cohen R, Basile D, Tougeron D and Phelip JM: Deficient mismatch repair/microsatellite unstable colorectal cancer: Diagnosis, prognosis and treatment. Eur J Cancer. 175:136–157. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Lamb NA, Bard JE, Loll-Krippleber R, Brown GW and Surtees JA: Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Genetics. 221:iyac0922022. View Article : Google Scholar : PubMed/NCBI

42 

Kašubová I, Holubeková V, Janíková K, Váňová B, Sňahničanová Z, Kalman M, Plank L and Lasabová Z: Next generation sequencing in molecular diagnosis of lynch syndrome-a pilot study using new stratification criteria. Acta Medica (Hradec Kralove). 61:98–102. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Castiglia D, Bernardini S, Alvino E, Pagani E, De Luca N, Falcinelli S, Pacchiarotti A, Bonmassar E, Zambruno G and D'Atri S: Concomitant activation of Wnt pathway and loss of mismatch repair function in human melanoma. Genes Chromosomes Cancer. 47:614–624. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Suzuki H, Hirata Y, Suzuki N, Ihara S, Sakitani K, Kobayashi Y, Kinoshita H, Hayakawa Y, Yamada A, Watabe H, et al: Characterization of a new small bowel adenocarcinoma cell line and screening of anti-cancer drug against small bowel adenocarcinoma. Am J Pathol. 185:550–562. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Xie X, Chen J, Wo D, Ma E, Ning Y, Peng J, Zhu W and Ren DN: Babao Dan is a robust anti-tumor agent via inhibiting wnt/β-catenin activation and cancer cell stemness. J Ethnopharmacol. 280:1144492021. View Article : Google Scholar : PubMed/NCBI

46 

Hashemi M, Hasani S, Hajimazdarany S, Ghadyani F, Olyaee Y, Khodadadi M, Ziyarani MF, Dehghanpour A, Salehi H, Kakavand A, et al: Biological functions and molecular interactions of Wnt/β-catenin in breast cancer: Revisiting signaling networks. Int J Biol Macromol. 232:1233772023. View Article : Google Scholar : PubMed/NCBI

47 

Alshahrani SH, Rakhimov N, Rana A, Alsaab HO, Hjazi A, Adile M, Abosaooda M, Abdulhussien Alazbjee AA, Alsalamy A and Mahmoudi R: Dishevelled: An emerging therapeutic oncogene in human cancers. Pathol Res Pract. 250:1547932023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Wei C, Wang S, Ding S, Li Y, Li Y, Zhang D, Zhu G and Meng Z: Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncol Lett 27: 52, 2024.
APA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y. ... Meng, Z. (2024). Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncology Letters, 27, 52. https://doi.org/10.3892/ol.2023.14184
MLA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27.2 (2024): 52.
Chicago
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27, no. 2 (2024): 52. https://doi.org/10.3892/ol.2023.14184
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Wei C, Wang S, Ding S, Li Y, Li Y, Zhang D, Zhu G and Meng Z: Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncol Lett 27: 52, 2024.
APA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y. ... Meng, Z. (2024). Role of prognostic gene DKK1 in oral squamous cell carcinoma. Oncology Letters, 27, 52. https://doi.org/10.3892/ol.2023.14184
MLA
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27.2 (2024): 52.
Chicago
Liu, Y., Wei, C., Wang, S., Ding, S., Li, Y., Li, Y., Zhang, D., Zhu, G., Meng, Z."Role of prognostic gene DKK1 in oral squamous cell carcinoma". Oncology Letters 27, no. 2 (2024): 52. https://doi.org/10.3892/ol.2023.14184
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