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Case Report Open Access

Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review

  • Authors:
    • Bao Ying
    • Tao Tang
    • Li-Xing Zhang
    • Jian-Wei Xiong
    • Kai-Feng Zhao
    • Jia-Wei Li
    • Guo Wu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China
    Copyright: © Ying et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 56
    |
    Published online on: December 13, 2023
       https://doi.org/10.3892/ol.2023.14189
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Abstract

A 37‑year‑old female patient was diagnosed with intrahepatic cholangiocarcinoma (ICC), with the lesion located in the right lobe of the liver. Despite radical resection, postoperative adjuvant chemotherapy and a combination of adjuvant chemotherapy and immunotherapy, the patient continued to experience multiple instances of intrahepatic tumor metastases. Furthermore, the patient exhibited significant adverse reactions to systemic chemotherapy and had poor treatment tolerance. Guidance from paraffin section fluorescence in situ hybridization gene sequencing was used to select a combination of immunotherapy and targeted therapy treatments with programmed cell death 1 (PD‑1)/PD‑1 ligand 1 antibody durvalumab and the targeted drug pemigatinib. The patient tolerated the treatment and has continued to survive for 28 months. According to imaging evaluations, the lesions continued to decrease, with some disappearing completely. The tumor marker carbohydrate antigen 19‑9 remained normal for >9 weeks during the treatment. This report described the patient's treatment process in detail and briefly reviewed relevant literature on the treatment progress of postoperative patients with ICC.
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Copy and paste a formatted citation
Spandidos Publications style
Ying B, Tang T, Zhang L, Xiong J, Zhao K, Li J and Wu G: Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review. Oncol Lett 27: 56, 2024.
APA
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., & Wu, G. (2024). Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review. Oncology Letters, 27, 56. https://doi.org/10.3892/ol.2023.14189
MLA
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., Wu, G."Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review". Oncology Letters 27.2 (2024): 56.
Chicago
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., Wu, G."Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review". Oncology Letters 27, no. 2 (2024): 56. https://doi.org/10.3892/ol.2023.14189
Copy and paste a formatted citation
x
Spandidos Publications style
Ying B, Tang T, Zhang L, Xiong J, Zhao K, Li J and Wu G: Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review. Oncol Lett 27: 56, 2024.
APA
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., & Wu, G. (2024). Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review. Oncology Letters, 27, 56. https://doi.org/10.3892/ol.2023.14189
MLA
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., Wu, G."Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review". Oncology Letters 27.2 (2024): 56.
Chicago
Ying, B., Tang, T., Zhang, L., Xiong, J., Zhao, K., Li, J., Wu, G."Precision therapy for intrahepatic cholangiocarcinoma: A case report on adjuvant treatment in a recurrent patient after surgery and literature review". Oncology Letters 27, no. 2 (2024): 56. https://doi.org/10.3892/ol.2023.14189
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