Decoding the diagnostic dilemma: Peripheral T‑cell lymphoma presenting as acute pancreatitis: A case report

Vikash,Fnu; Vikash,Sindhu; Mehta,Ansh; Nagraj,Sanjana; Patel,Sunny; Ho,Sammy; Kotler,Donald

doi:10.3892/ol.2023.14206

February-2024 Volume 27 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2024 Volume 27 Issue 2

Full Size Image

Case Report Open Access

Decoding the diagnostic dilemma: Peripheral T‑cell lymphoma presenting as acute pancreatitis: A case report

Authors:
- Fnu Vikash
- Sindhu Vikash
- Ansh Mehta
- Sanjana Nagraj
- Sunny Patel
- Sammy Ho
- Donald Kotler
View Affiliations / Copyright

Affiliations: Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Hematology and Oncology, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Gastroenterology, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA

Copyright: © Vikash et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 73
|
Published online on: December 22, 2023

https://doi.org/10.3892/ol.2023.14206
Expand metrics +

Abstract

Peripheral T cell lymphoma (PTCL) is a rare form of non‑Hodgkin lymphoma characterized by the origin of mature T‑cells. PTCL demonstrates atypical clinical features and involves both nodal and extra‑nodal sites. The diagnosis and treatment of PTCL can prove to be challenging, as it is often detected at advanced stages and is resistant to conventional chemotherapy treatments. The present report describes a 55‑year‑old male patient who presented with acute pancreatitis, and imaging suggested a soft tissue mass in the pancreatic head indicating pancreatic adenocarcinoma. Further investigation through ultrasound‑guided biopsy led to the diagnosis of pancreatic PTCL not otherwise specified.

View Figures

View References

1	Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI
2	Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, Rüdiger T, Pileri S, Nakamura S, Nathwani B, et al: Peripheral T-cell lymphoma, not otherwise specified: A report of 340 cases from the international peripheral T-cell lymphoma project. Blood. 117:3402–3408. 2011. View Article : Google Scholar : PubMed/NCBI
3	Lee J, Park KS, Kang MH, Kim Y, Son SM, Choi H, Choi JW and Ryu DH: Primary hepatic peripheral T-cell lymphoma mimicking hepatocellular carcinoma: A case report. Ann Surg Treat Res. 93:110–114. 2017. View Article : Google Scholar : PubMed/NCBI
4	Petrova M, Gomes MM, Carda JPN and Pereira de Moura J: Hepatosplenic T-cell lymphoma in a young immunocompetent man. BMJ Case Rep. 2016:bcr20162144142016. View Article : Google Scholar : PubMed/NCBI
5	Jiang M, Bennani NN and Feldman AL: Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 10:239–249. 2017. View Article : Google Scholar : PubMed/NCBI
6	Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, et al: The ECHELON-2 Trial: 5-Year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma. Ann Oncol. 33:288–298. 2022. View Article : Google Scholar : PubMed/NCBI
7	Avlonitis VS and Linos D: Primary hepatic lymphoma: A review. Eur J Surg. 165:725–729. 1999. View Article : Google Scholar : PubMed/NCBI
8	Thomas PC, Nash GF and Aldridge MC: Pancreatic acinar cell carcinoma presenting as acute pancreatitis. HPB (Oxford). 5:111–113. 2003. View Article : Google Scholar : PubMed/NCBI
9	Safadi R, Or R, Bar Ziv J and Polliack A: Lymphoma-associated pancreatitis as a presenting manifestation of immunoblastic lymphoma. Leuk Lymphoma. 12:317–319. 1994. View Article : Google Scholar : PubMed/NCBI
10	To CA, Quigley MM, Saven A and Nicholson L: Masquerade without a mass: An unusual cause of severe acute pancreatitis. J Gastrointest Oncol. 4:114–117. 2013.PubMed/NCBI
11	Gazelle GS, Lee MJ, Hahn PF, Goldberg MA, Rafaat N and Mueller PR: US, CT, and MRI of primary and secondary liver lymphoma. J Comput Assist Tomogr. 18:412–415. 1994. View Article : Google Scholar : PubMed/NCBI
12	Saif MW: Primary pancreatic lymphomas. JOP. 7:262–273. 2006.PubMed/NCBI
13	Merkle EM, Bender GN and Brambs HJ: Imaging findings in pancreatic lymphoma: Differential aspects. AJR Am J Roentgenol. 174:671–675. 2000. View Article : Google Scholar : PubMed/NCBI
14	Foss FM, Zinzani PL, Vose JM, Gascoyne RD, Rosen ST and Tobinai K: Peripheral T-cell lymphoma. Blood. 117:6756–6767. 2011. View Article : Google Scholar : PubMed/NCBI
15	Jeon YK, Kim JH, Sung JY, Han JH and Ko YH; Hematopathology Study Group of the Korean Society of Pathologists, : Epstein-Barr virus-positive nodal T/NK-cell lymphoma: An analysis of 15 cases with distinct clinicopathological features. Hum Pathol. 46:981–990. 2015. View Article : Google Scholar : PubMed/NCBI
16	Liu Z, Medeiros LJ and Young KH: Peripheral T-cell lymphoma with unusual clinical presentation of rhabdomyolysis. Hematol Oncol. 35:125–129. 2017. View Article : Google Scholar : PubMed/NCBI
17	Kawanishi K, Ohyama Y, Kanai Y, Hirase T, Tanaka H, Miyatake J, Tatsumi Y, Ashida T, Nakamine H and Matsumura I: Sub-acute demyelinating polyradiculoneuropathy as an initial symptom of peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). Intern Med. 51:2015–2020. 2012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Decoding the diagnostic dilemma: Peripheral T‑cell lymphoma presenting as acute pancreatitis: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles