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Article

Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis

  • Authors:
    • Boyuan Zou
    • Ning Ning
    • Yichao Yan
    • Yankai Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Retroperitoneal Tumor and Anorectal Surgery, Peking University International Hospital, Beijing 102206, P.R. China, Department of Gastroenterological Surgery, Peking University International Hospital, Beijing 102206, P.R. China, Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Peking University People's Hospital, Beijing 100044, P.R. China
  • Article Number: 80
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    Published online on: January 5, 2024
       https://doi.org/10.3892/ol.2024.14214
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Abstract

Rectal cancer is one of the most malignant tumors, and postoperative recurrence and metastasis are the main reasons for treatment failure. Lymph node metastasis is the main metastatic pathway of rectal cancer. The present study aimed to investigate the role of lateral lymph node dissection (LLND) in patients with rectal cancer using a meta‑analysis. Articles in Chinese and English related to the application of LLND in patients with rectal cancer were retrieved and eligible studies were selected for data analysis. Evaluation indicators included the 5‑year survival rate, recurrence rate, urinary system function and operation time. The random‑effects model was utilized for the analysis. A total of 10 studies that met the eligibility criteria were selected, comprising 2,272 patients, including 1,101 cases in the LLND group and 1,171 cases in the non‑LLND group. No significant difference was found between the two groups in terms of local recurrence rate, 5‑year disease‑free survival (DFS) rate, and DFS rate at the follow‑up. It is noteworthy that cases in the LLND group had no significantly longer overall survival, but had a higher 5‑year survival rate. However, cases in the LLND group had a longer operation time and worse urinary dysfunction. The results remained consistent throughout separate analyses for different research quality sources. The present meta‑analysis showed that LLND provided a specific advantage in prolonging survival time. However, it was associated with prolonged operation time and an increased incidence of urinary dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
Zou B, Ning N, Yan Y and Zhang Y: Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis. Oncol Lett 27: 80, 2024.
APA
Zou, B., Ning, N., Yan, Y., & Zhang, Y. (2024). Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis. Oncology Letters, 27, 80. https://doi.org/10.3892/ol.2024.14214
MLA
Zou, B., Ning, N., Yan, Y., Zhang, Y."Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis". Oncology Letters 27.2 (2024): 80.
Chicago
Zou, B., Ning, N., Yan, Y., Zhang, Y."Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis". Oncology Letters 27, no. 2 (2024): 80. https://doi.org/10.3892/ol.2024.14214
Copy and paste a formatted citation
x
Spandidos Publications style
Zou B, Ning N, Yan Y and Zhang Y: Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis. Oncol Lett 27: 80, 2024.
APA
Zou, B., Ning, N., Yan, Y., & Zhang, Y. (2024). Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis. Oncology Letters, 27, 80. https://doi.org/10.3892/ol.2024.14214
MLA
Zou, B., Ning, N., Yan, Y., Zhang, Y."Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis". Oncology Letters 27.2 (2024): 80.
Chicago
Zou, B., Ning, N., Yan, Y., Zhang, Y."Lateral lymph node dissection can increase overall survival and 5‑year survival rate of rectal cancer patients: A meta‑analysis". Oncology Letters 27, no. 2 (2024): 80. https://doi.org/10.3892/ol.2024.14214
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