Open Access

Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review)

  • Authors:
    • Haihong Jiang
    • Qinlu Zhang
  • View Affiliations

  • Published online on: January 5, 2024     https://doi.org/10.3892/ol.2024.14221
  • Article Number: 87
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Immune checkpoint inhibitors (ICIs) are commonly utilized in tumor treatment. However, they still have limitations, including insufficient effectiveness and unavoidable adverse events. It has been demonstrated that gut microbiota can influence the effectiveness of ICIs, although the precise mechanism remains unclear. Gut microbiota plays a crucial role in the formation and development of the immune system. Gut microbiota and their associated metabolites play a regulatory role in immune balance. Tumor occurrence and development are linked to their ability to evade recognition and destruction by the immune system. The purpose of ICIs treatment is to reinitiate the immune system's elimination of tumor cells. Thus, the immune system acts as a communication bridge between gut microbiota and ICIs. Varied composition and characteristics of gut microbiota result in diverse outcomes in ICIs treatment. Certain gut microbiota‑related metabolites also influence the therapeutic efficacy of ICIs to some extent. The administration of antibiotics before or during ICIs treatment can diminish treatment effectiveness. The utilization of probiotics and fecal transplantation can partially alter the outcome of ICIs treatment. The present review synthesized previous studies to examine the association between gut microbiota and ICIs, elucidated the role of gut microbiota and its associated factors in ICIs treatment, and offered direction for future research.
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February-2024
Volume 27 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang H and Jiang H: Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review). Oncol Lett 27: 87, 2024
APA
Jiang, H., & Jiang, H. (2024). Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review). Oncology Letters, 27, 87. https://doi.org/10.3892/ol.2024.14221
MLA
Jiang, H., Zhang, Q."Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review)". Oncology Letters 27.2 (2024): 87.
Chicago
Jiang, H., Zhang, Q."Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review)". Oncology Letters 27, no. 2 (2024): 87. https://doi.org/10.3892/ol.2024.14221