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Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma

  • Authors:
    • Fangzhou Guo
    • Guoyuan Ling
    • Zhenzhu Zhai
    • Yi Lei
    • Ligen Mo
    • Haozhe Piao
  • View Affiliations / Copyright

    Affiliations: Graduate School, The Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116000, P.R. China, Department of Neurosurgery, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110801, P.R. China, Department of Neurosurgery, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 88
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    Published online on: January 5, 2024
       https://doi.org/10.3892/ol.2024.14222
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Abstract

Fatty acid oxidation (FAO) plays a crucial role in glioma metabolism and its interaction with the immune microenvironment. The aim of the present study was to investigate the relationship between FAO‑related genes and glioma by constructing gene clusters using a glioma cohort. A total of 287 differentially expressed genes related to FAO were identified and the top 50 genes were selected based on their P‑values. Subsequently, patients were classified into two distinct gene subtypes (A and B) based on these genes. Scores for each patient were calculated using the 50 genes and the patients were divided into the high and low‑score groups accordingly. Patients in subtype B exhibited higher tumor grades and poor prognostic factors such as older age and worse survival rates. The high‑score subgroup had unfavorable indicators, including isocitrate dehydrogenase 1 wild‑type, high tumor grade and 1p19q non‑codeleted, while immune checkpoint expression was generally higher in the high‑score subgroup. The constructed scoring model was validated using an external dataset, and the tissue inhibitor of metalloproteinase 1 gene was identified through protein interaction analysis, suggesting its potential involvement in glioma malignancy and promotion of glioblastoma proliferation. In conclusion, FAO‑related genes may contribute to tumor development through immune mechanisms and the present study may provide novel insights for potential therapeutic strategies in glioma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Guo F, Ling G, Zhai Z, Lei Y, Mo L and Piao H: Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma. Oncol Lett 27: 88, 2024.
APA
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., & Piao, H. (2024). Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma. Oncology Letters, 27, 88. https://doi.org/10.3892/ol.2024.14222
MLA
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., Piao, H."Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma". Oncology Letters 27.2 (2024): 88.
Chicago
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., Piao, H."Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma". Oncology Letters 27, no. 2 (2024): 88. https://doi.org/10.3892/ol.2024.14222
Copy and paste a formatted citation
x
Spandidos Publications style
Guo F, Ling G, Zhai Z, Lei Y, Mo L and Piao H: Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma. Oncol Lett 27: 88, 2024.
APA
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., & Piao, H. (2024). Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma. Oncology Letters, 27, 88. https://doi.org/10.3892/ol.2024.14222
MLA
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., Piao, H."Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma". Oncology Letters 27.2 (2024): 88.
Chicago
Guo, F., Ling, G., Zhai, Z., Lei, Y., Mo, L., Piao, H."Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma". Oncology Letters 27, no. 2 (2024): 88. https://doi.org/10.3892/ol.2024.14222
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