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Article Open Access

ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression

  • Authors:
    • Letian Chen
    • Dongdong Zhang
    • Yujuan Chen
    • Huilan Zhu
    • Zhipeng Liu
    • Zhiping Yu
    • Junping Xie
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China, Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 96
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    Published online on: January 11, 2024
       https://doi.org/10.3892/ol.2024.14229
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Abstract

Origin recognition complexes (ORCs) are vital in the control of DNA replication and the progression of the cell cycle, however the precise function and mechanism of ORC6 in non‑small cell lung cancer (NSCLC) is still not well understood. The present study used bioinformatics methods to assess the predictive significance of ORC6 expression in NSCLC. Moreover, the expression of ORC6 was further evaluated using reverse transcription‑quantitative PCR and western blotting, and its functional significance in lung cancer was assessed via knockdown experiments using small interfering RNA. A significant association was demonstrated between the expression of ORC6 and the clinical features of NSCLC. In particular, elevated levels of ORC6 were significantly strongly correlated with an unfavorable prognosis. Multivariate analysis demonstrated that increased ORC6 expression independently contributed to the risk of overall survival (HR 1.304; P=0.015) in individuals diagnosed with NSCLC. Analysis of Kaplan‑Meier plots demonstrated that ORC6 expression served as a valuable indicator for diagnosing and predicting the prognosis of NSCLC. Moreover, in vitro studies demonstrated that modified ORC6 expression had a significant impact on the proliferation, migration and metastasis of NSCLC cells. NSCLC cell lines (H1299 and mH1650) exhibited markedly higher ORC6 expression than normal lung cell lines. The results of the present study indicated a strong association between the expression of ORC6 and the clinicopathological characteristics of NSCLC, which suggested its potential as a reliable biomarker for predicting NSCLC. Furthermore, ORC6 may have important therapeutic implications in the management of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Zhang D, Chen Y, Zhu H, Liu Z, Yu Z and Xie J: ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression. Oncol Lett 27: 96, 2024.
APA
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., & Xie, J. (2024). ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression. Oncology Letters, 27, 96. https://doi.org/10.3892/ol.2024.14229
MLA
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., Xie, J."ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression". Oncology Letters 27.3 (2024): 96.
Chicago
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., Xie, J."ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression". Oncology Letters 27, no. 3 (2024): 96. https://doi.org/10.3892/ol.2024.14229
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Zhang D, Chen Y, Zhu H, Liu Z, Yu Z and Xie J: ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression. Oncol Lett 27: 96, 2024.
APA
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., & Xie, J. (2024). ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression. Oncology Letters, 27, 96. https://doi.org/10.3892/ol.2024.14229
MLA
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., Xie, J."ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression". Oncology Letters 27.3 (2024): 96.
Chicago
Chen, L., Zhang, D., Chen, Y., Zhu, H., Liu, Z., Yu, Z., Xie, J."ORC6 acts as an effective prognostic predictor for non‑small cell lung cancer and is closely associated with tumor progression". Oncology Letters 27, no. 3 (2024): 96. https://doi.org/10.3892/ol.2024.14229
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