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Article Open Access

OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1

  • Authors:
    • Hebing Wang
    • Sumei Han
    • Jian Xiao
    • Xinghang Fu
    • Wenfeng Chen
    • Dexiang Zhuo
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian 365000, P.R. China, Department of Dermatology, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian 365000, P.R. China, Department of Laboratory Medicine, Sanming First Hospital Affiliated to Fujian Medical University, Sanming, Fujian 365000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 102
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    Published online on: January 16, 2024
       https://doi.org/10.3892/ol.2024.14235
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Abstract

Breast cancer is a leading cause of cancer‑related death in women worldwide; therefore, there is an urgent need to develop novel therapies and drugs that prolong the survival and improve the quality of life of patients with breast cancer. In the present study, the effects and underlying mechanisms of OTU domain‑containing 7B (OTUD7B) knockdown on breast cancer were investigated using MDA‑MB‑468, MDA‑MB‑453 and MCF7 cell lines. The results of Cell Counting Kit 8, colony formation and tumor sphere formation experiments showed that OTUD7B knockdown caused a significant decrease in the proliferation and sphere formation ability of MDA‑MB‑468, MDA‑MB‑453 and MCF7 cells in vitro. Moreover, western blotting results showed that CD44, EpCAM, SOX2 and Nanog protein levels were significantly decreased following OTUD7B knockdown. These findings indicated that OTUD7B knockdown reduced the proliferation and stemness of breast cancer cells. Co‑immunoprecipitation assays demonstrated that OTUD7B interacted with forkhead box protein M1 (FOXM1) and reduced the polyubiquitylation of FOXM1 in breast cancer cells; accordingly, FOXM1 protein levels were significantly decreased by OTUD7B knockdown. Furthermore, the overexpression of FOXM1 reduced the inhibitory effects of OTUD7B knockdown on breast cancer cells. The findings of the present study provide new insights into the oncogenic role of OTUD7B in breast cancer and indicate that OTUD7B may serve as a therapeutic target for breast cancer.
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1 

Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, et al: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 26:1275–1281. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y and Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 121:2750–2767. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Harbeck N, Penault-Llorca F, Cortes J, Gnant M, Houssami N, Poortmans P, Ruddy K, Tsang J and Cardoso F: Breast cancer. Nat Rev Dis Primers. 5:662019. View Article : Google Scholar : PubMed/NCBI

4 

Waks AG and Winer EP: Breast cancer treatment: A review. JAMA. 321:288–300. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Barzaman K, Karami J, Zarei Z, Hosseinzadeh A, Kazemi MH, Moradi-Kalbolandi S, Safari E and Farahmand L: Breast cancer: Biology, biomarkers, and treatments. Int Immunopharmacol. 84:1065352020. View Article : Google Scholar : PubMed/NCBI

6 

Mevissen TET and Komander D: Mechanisms of deubiquitinase specificity and regulation. Annu Rev Biochem. 86:159–192. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Lai KP, Chen J and Tse WKF: Role of deubiquitinases in human cancers: Potential targeted therapy. Int J Mol Sci. 21:25482020. View Article : Google Scholar : PubMed/NCBI

8 

Li S, Zhang H and Wei X: Roles and Mechanisms of Deubiquitinases (DUBs) in breast cancer progression and targeted drug discovery. Life (Basel). 11:9652021.PubMed/NCBI

9 

Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, et al: Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene. 31:4599–4608. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wang JH, Wei W, Guo ZX, Shi M and Guo RP: Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma. J Transl Med. 13:412015. View Article : Google Scholar : PubMed/NCBI

11 

Zhang B, Wang H, Yang L, Zhang Y, Wang P, Huang G, Zheng J, Ren H and Qin S: OTUD7B and NIK expression in non-small cell lung cancer: Association with clinicopathological features and prognostic implications. Pathol Res Pract. 212:893–898. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang JH, Zhong XP, Zhang YF, Wu XL, Li SH, Jian PE, Ling YH, Shi M, Chen MS, Wei W, et al: Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma. Cell Death Dis. 8:e30432017. View Article : Google Scholar : PubMed/NCBI

13 

Lei S, He Z, Chen T, Guo X, Zeng Z, Shen Y and Jiang J: Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway. J Exp Clin Cancer Res. 38:4702019. View Article : Google Scholar : PubMed/NCBI

14 

Qiu S, Liu Y, Gui A, Xia Z, Liu W, Gu JJ, Zuo J, Yang L and Zhang Q: Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma. J Cancer. 13:998–1004. 2022. View Article : Google Scholar : PubMed/NCBI

15 

Tang J, Wu Z, Tian Z, Chen W and Wu G: OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation. Cell Death Dis. 12:5342021. View Article : Google Scholar : PubMed/NCBI

16 

Gong Z, Li A, Ding J, Li Q, Zhang L, Li Y, Meng Z, Chen F, Huang J, Zhou D, et al: OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis. Adv Sci (Weinh). 8:e20045042021. View Article : Google Scholar : PubMed/NCBI

17 

Chiu HW, Lin HY, Tseng IJ and Lin YF: OTUD7B upregulation predicts a poor response to paclitaxel in patients with triple-negative breast cancer. Oncotarget. 9:553–565. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Chen H, Yu Y, Yang M, Huang H, Ma S, Hu J, Xi Z, Guo H, Yao G, Yang L, et al: YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner. Cell Biosci. 12:192022. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Cui CP, Zhang Y, Wang C, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH, et al: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nat Commun. 9:46482018. View Article : Google Scholar : PubMed/NCBI

21 

Sher G, Masoodi T, Patil K, Akhtar S, Kuttikrishnan S, Ahmad A and Uddin S: Dysregulated FOXM1 signaling in the regulation of cancer stem cells. Semin Cancer Biol. 86:107–121. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Bonacci T, Suzuki A, Grant GD, Stanley N, Cook JG, Brown NG and Emanuele MJ: Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates. EMBO J. 37:e987012018. View Article : Google Scholar : PubMed/NCBI

23 

Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R and Kilshaw PJ: Isolation and characterization of two novel A20-like proteins. Biochem J. 357:617–623. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Evans PC, Smith TS, Lai MJ, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R, Blundell TL and Kilshaw PJ: A novel type of deubiquitinating enzyme. J Biol Chem. 278:23180–23186. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Enesa K, Zakkar M, Chaudhury H, Luong le A, Rawlinson L, Mason JC, Haskard DO, Dean JL and Evans PC: NF-kappaB suppression by the deubiquitinating enzyme Cezanne: A novel negative feedback loop in pro-inflammatory signaling. J Biol Chem. 283:7036–7045. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zhu QZ, Liu HY, Zhao XY, Qiu LJ, Zhou TT, Wang XY, Chen HP and Xiao ZQ: DJ-1 activates the noncanonical NF-κB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells. Mol Biol Rep. 48:6075–6083. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Lin DD, Shen Y, Qiao S, Liu WW, Zheng L, Wang YN, Cui N, Wang YF, Zhao S and Shi JH: Upregulation of OTUD7B (Cezanne) promotes tumor progression via AKT/VEGF pathway in lung squamous carcinoma and adenocarcinoma. Front Oncol. 9:8622019. View Article : Google Scholar : PubMed/NCBI

28 

Prasad S, Ramachandran S, Gupta N, Kaushik I and Srivastava SK: Cancer cells stemness: A doorstep to targeted therapy. Biochim Biophys Acta Mol Basis Dis. 1866:1654242020. View Article : Google Scholar : PubMed/NCBI

29 

Ibragimova M, Tsyganov M and Litviakov N: Tumour stem cells in breast cancer. Int J Mol Sci. 23:50582022. View Article : Google Scholar : PubMed/NCBI

30 

Sun HL, Men JR, Liu HY, Liu MY and Zhang HS: FOXM1 facilitates breast cancer cell stemness and migration in YAP1-dependent manner. Arch Biochem Biophys. 685:1083492020. View Article : Google Scholar : PubMed/NCBI

31 

Modi A, Purohit P, Roy D, Vishnoi JR, Pareek P, Elhence P, Singh P, Sharma S, Sharma P and Misra S: FOXM1 mediates GDF-15 dependent stemness and intrinsic drug resistance in breast cancer. Mol Biol Rep. 49:2877–2888. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Tsao AN, Chuang YS, Lin YC, Su Y and Chao TC: Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway. Oncol Rep. 47:1052022. View Article : Google Scholar : PubMed/NCBI

33 

Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, et al: ZRANB1 Is an EZH2 deubiquitinase and a potential therapeutic target in breast cancer. Cell Rep. 23:823–837. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Xiao H, Claret FX and Shen Q: The novel Jab1 inhibitor CSN5i-3 suppresses cell proliferation and induces apoptosis in human breast cancer cells. Neoplasma. 66:481–486. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Song Z, Tu X, Zhou Q, Huang J, Chen Y, Liu J, Lee S, Kim W, Nowsheen S, Luo K, et al: A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair. Cell Death Dis. 10:3982019. View Article : Google Scholar : PubMed/NCBI

36 

Liao Y, Xia X, Liu N, Cai J, Guo Z, Li Y, Jiang L, Dou QP, Tang D, Huang H, et al: Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination. Oncogene. 37:1896–1910. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Ma A, Tang M, Zhang L, Wang B, Yang Z, Liu Y, Xu G, Wu L, Jing T, Xu X, et al: USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis. Oncogene. 38:2405–2419. 2019. View Article : Google Scholar : PubMed/NCBI

38 

He J, Lee HJ, Saha S, Ruan D, Guo H and Chan CH: Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy. Cell Death Dis. 10:2852019. View Article : Google Scholar : PubMed/NCBI

39 

Ahram M, Abdullah MS, Mustafa SA, Alsafadi DB and Battah AH: Androgen downregulates desmocollin-2 in association with induction of mesenchymal transition of breast MDA-MB-453 cancer cells. Cytoskeleton (Hoboken NJ). 78:391–399. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Liubomirski Y, Lerrer S, Meshel T, Rubinstein-Achiasaf L, Morein D, Wiemann S, Körner C and Ben-Baruch A: Tumor-stroma-inflammation networks promote pro-metastatic chemokines and aggressiveness characteristics in triple-negative breast cancer. Front Immunol. 10:7572019. View Article : Google Scholar : PubMed/NCBI

41 

Pruteanu LL, Braicu C, Módos D, Jurj MA, Raduly LZ, Zănoagă O, Magdo L, Cojocneanu R, Paşca S, Moldovan C, et al: Targeting cell death mechanism specifically in triple negative breast cancer cell lines. Int J Mol Sci. 23:47842022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Han S, Xiao J, Fu X, Chen W and Zhuo D: OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1. Oncol Lett 27: 102, 2024.
APA
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., & Zhuo, D. (2024). OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1. Oncology Letters, 27, 102. https://doi.org/10.3892/ol.2024.14235
MLA
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., Zhuo, D."OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1". Oncology Letters 27.3 (2024): 102.
Chicago
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., Zhuo, D."OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1". Oncology Letters 27, no. 3 (2024): 102. https://doi.org/10.3892/ol.2024.14235
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Han S, Xiao J, Fu X, Chen W and Zhuo D: OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1. Oncol Lett 27: 102, 2024.
APA
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., & Zhuo, D. (2024). OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1. Oncology Letters, 27, 102. https://doi.org/10.3892/ol.2024.14235
MLA
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., Zhuo, D."OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1". Oncology Letters 27.3 (2024): 102.
Chicago
Wang, H., Han, S., Xiao, J., Fu, X., Chen, W., Zhuo, D."OTUD7B knockdown inhibits the proliferation and stemness of breast cancer cells by destabilizing FOXM1". Oncology Letters 27, no. 3 (2024): 102. https://doi.org/10.3892/ol.2024.14235
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