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Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer

  • Authors:
    • Gendensuren Dorjkhorloo
    • Bilguun Erkhem‑Ochir
    • Takuya Shiraishi
    • Makoto Sohda
    • Haruka Okami
    • Arisa Yamaguchi
    • Ikuma Shioi
    • Chika Komine
    • Nobuhiro Nakazawa
    • Naoya Ozawa
    • Yuta Shibasaki
    • Takuhisa Okada
    • Katsuya Osone
    • Akihiko Sano
    • Makoto Sakai
    • Hiroomi Ogawa
    • Takehiko Yokobori
    • Ken Shirabe
    • Hiroshi Saeki
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371‑8511, Japan, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, Maebashi, Gunma 371‑8511, Japan
    Copyright: © Dorjkhorloo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 104
    |
    Published online on: January 17, 2024
       https://doi.org/10.3892/ol.2024.14237
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Abstract

Tumor‑infiltrating immune cells, such as lymphocytes and macrophages, have been associated with tumor aggressiveness, prognosis and treatment response in colorectal cancer (CRC). An immune scoring system, Immunoscore (IS), based on tumor‑infiltrating T cells in stage I‑III CRC, was used to predict prognosis. An alternative immune scoring signature of immune activation (SIA) reflects the balance between anti‑ and pro‑tumoral immune components. The present study aimed to evaluate the prognostic value of modified IS (mIS) and modified SIA (mSIA) in locally advanced pathological T4 (pT4) CRC, including stage IV CRC. Immunohistochemical staining for immune cell markers, such as CD3 (pan‑T cell marker), CD8 (anti‑tumoral cytotoxic T cell marker) and CD163 (tumor‑supportive macrophage marker), in specimens from patients with radically resected pT4 CRC at stages II‑IV was performed. mIS levels in the T4 CRC cohort were not associated with prognosis. However, low mSIA levels were associated with low survival. Furthermore, low mSIA was an independent predictor of recurrence in patients with radically resected pT4 CRC. In patients with CRC who did not receive postoperative adjuvant chemotherapy, low mSIA was a major poor prognostic factor; however, this was not observed in patients receiving adjuvant chemotherapy. Evaluation of the tumor‑infiltrating immune cell population could serve as a valuable marker of recurrence and poor prognosis in patients with locally advanced CRC. mSIA assessment after radical CRC resection may be promising for identifying high‑risk patients with pT4 CRC who require aggressive adjuvant chemotherapy.
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1 

Laghi L, Negri F, Gaiani F, Cavalleri T, Grizzi F, De'Angelis GL and Malesci A: Prognostic and predictive cross-roads of microsatellite instability and immune response to colon cancer. Int J Mol Sci. 21:96802020. View Article : Google Scholar : PubMed/NCBI

2 

Brummel K, Eerkens AL, de Bruyn M and Nijman HW: Tumour-infiltrating lymphocytes: From prognosis to treatment selection. Br J Cancer. 128:451–458. 2023. View Article : Google Scholar : PubMed/NCBI

3 

Zhang Q and Sioud M: Tumor-associated macrophage subsets: Shaping polarization and targeting. Int J Mol Sci. 24:74932023. View Article : Google Scholar : PubMed/NCBI

4 

Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N and Baba H: Preoperative skeletal muscle status is associated with tumor-infiltrating lymphocytes and prognosis in patients with colorectal cancer. Ann Gastroenterol Surg. 6:658–666. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Melssen MM, Sheybani ND, Leick KM and Slingluff CL Jr: Barriers to immune cell infiltration in tumors. J Immunother Cancer. 11:e0064012023. View Article : Google Scholar : PubMed/NCBI

6 

Xiao Z, Todd L, Huang L, Noguera-Ortega E, Lu Z, Huang L, Kopp M, Li Y, Pattada N, Zhong W, et al: Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors. Nat Commun. 14:51102023. View Article : Google Scholar : PubMed/NCBI

7 

Mao X, Xu J, Wang W, Liang C, Hua J, Liu J, Zhang B, Meng Q, Yu X and Shi S: Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: New findings and future perspectives. Mol Cancer. 20:1312021. View Article : Google Scholar : PubMed/NCBI

8 

Bais C, Mueller B, Brady MF, Mannel RS, Burger RA, Wei W, Marien KM, Kockx MM, Husain A, Birrer MJ, et al: Tumor microvessel density as a potential predictive marker for bevacizumab benefit: GOG-0218 biomarker analyses. J Natl Cancer Inst. 109:djx0662017. View Article : Google Scholar : PubMed/NCBI

9 

Zeng Q, Mousa M, Nadukkandy AS, Franssens L, Alnaqbi H, Alshamsi FY, Safar HA and Carmeliet P: Understanding tumour endothelial cell heterogeneity and function from single-cell omics. Nat Rev Cancer. 23:544–564. 2023. View Article : Google Scholar : PubMed/NCBI

10 

Hendry SA, Farnsworth RH, Solomon B, Achen MG, Stacker SA and Fox SB: The role of the tumor vasculature in the host immune response: Implications for therapeutic strategies targeting the tumor microenvironment. Front Immunol. 7:6212016. View Article : Google Scholar : PubMed/NCBI

11 

Heryanto YD and Imoto S: The transcriptome signature analysis of the epithelial-mesenchymal transition and immune cell infiltration in colon adenocarcinoma. Sci Rep. 13:183832023. View Article : Google Scholar : PubMed/NCBI

12 

Chae YK, Chang S, Ko T, Anker J, Agte S, Iams W, Choi WM, Lee K and Cruz M: Epithelial-mesenchymal transition (EMT) signature is inversely associated with T-cell infiltration in non-small cell lung cancer (NSCLC). Sci Rep. 8:29182018. View Article : Google Scholar : PubMed/NCBI

13 

Singh S and Chakrabarti R: Consequences of EMT-driven changes in the immune microenvironment of breast cancer and therapeutic response of cancer cells. J Clin Med. 8:6422019. View Article : Google Scholar : PubMed/NCBI

14 

Jiang Y and Zhan H: Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion. Cancer Lett. 468:72–81. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Hasan J, Byers R and Jayson GC: Intra-tumoural microvessel density in human solid tumours. Br J Cancer. 86:1566–1577. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Ning H, Shao QQ, Ding KJ, Gao DX, Lu QL, Cao QW, Niu ZH, Fu Q, Zhang CH, Qu X and Lü JJ: Tumor-infiltrating regulatory T cells are positively correlated with angiogenic status in renal cell carcinoma. Chin Med J (Engl). 125:2120–2125. 2012.PubMed/NCBI

17 

Zhang P, Ma Y, Lv C, Huang M, Li M, Dong B, Liu X, An G, Zhang W, Zhang J, et al: Upregulation of programmed cell death ligand 1 promotes resistance response in non-small-cell lung cancer patients treated with neo-adjuvant chemotherapy. Cancer Sci. 107:1563–1571. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Ramser M, Eichelberger S, Däster S, Weixler B, Kraljević M, Mechera R, Tampakis A, Delko T, Güth U, Stadlmann S, et al: High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy. BMC Cancer. 18:4252018. View Article : Google Scholar : PubMed/NCBI

19 

Liu X, Huang Y, Qi Y, Wu S, Hu F, Wang J, Shu K, Zhang H, Bartsch JW, Nimsky C, et al: The GBM tumor microenvironment as a modulator of therapy response: ADAM8 causes tumor infiltration of tams through HB-EGF/EGFR-mediated CCL2 expression and overcomes TMZ chemosensitization in glioblastoma. Cancers (Basel). 14:49102022. View Article : Google Scholar : PubMed/NCBI

20 

Malka D, Lièvre A, André T, Taïeb J, Ducreux M and Bibeau F: Immune scores in colorectal cancer: Where are we? Eur J Cancer. 140:105–118. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Kuwahara T, Hazama S, Suzuki N, Yoshida S, Tomochika S, Nakagami Y, Matsui H, Shindo Y, Kanekiyo S, Tokumitsu Y, et al: Intratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable of resectable colorectal cancer. Br J Cancer. 121:659–665. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Bergsland CH, Jeanmougin M, Moosavi SH, Svindland A, Bruun J, Nesbakken A, Sveen A and Lothe RA: Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer. Mod Pathol. 35:1236–1246. 2022. View Article : Google Scholar : PubMed/NCBI

23 

Sconocchia G, Eppenberger S, Spagnoli GC, Tornillo L, Droeser R, Caratelli S, Ferrelli F, Coppola A, Arriga R, Lauro D, et al: NK cells and T cells cooperate during the clinical course of colorectal cancer. Oncoimmunology. 3:e9521972014. View Article : Google Scholar : PubMed/NCBI

24 

Medrek C, Pontén F, Jirström K and Leandersson K: The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer. 12:3062012. View Article : Google Scholar : PubMed/NCBI

25 

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, et al: International validation of the consensus Immunoscore for the classification of colon cancer: A prognostic and accuracy study. Lancet. 391:2128–2139. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Mezheyeuski A, Backman M, Mattsson J, Martín-Bernabé A, Larsson C, Hrynchyk I, Hammarström K, Ström S, Ekström J, Mauchanski S, et al: An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers. EBioMedicine. 88:1044522023. View Article : Google Scholar : PubMed/NCBI

27 

Minami K, Hiwatashi K, Ueno S, Sakoda M, Iino S, Okumura H, Hashiguchi M, Kawasaki Y, Kurahara H, Mataki Y, et al: Prognostic significance of CD68, CD163 and folate receptor-β positive macrophages in hepatocellular carcinoma. Exp Ther Med. 15:4465–4476. 2018.PubMed/NCBI

28 

Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, et al: Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination. Gastric Cancer. 19:1052–1065. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Troiano G, Caponio VCA, Adipietro I, Tepedino M, Santoro R, Laino L, Lo Russo L, Cirillo N and Lo Muzio L: Prognostic significance of CD68+ and CD163+ tumor associated macrophages in head and neck squamous cell carcinoma: A systematic review and meta-analysis. Oral Oncol. 93:66–75. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Shabo I, Olsson H, Sun XF and Svanvik J: Expression of the macrophage antigen CD163 in rectal cancer cells is associated with early local recurrence and reduced survival time. Int J Cancer. 125:1826–1831. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Shabo I, Stål O, Olsson H, Doré S and Svanvik J: Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival. Int J Cancer. 123:780–786. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Ma S, Zhao Y, Liu X, Sun Zhang A, Zhang H, Hu G and Sun XF: FCD163 as a potential biomarker in colorectal cancer for tumor microenvironment and cancer prognosis: A Swedish study from tissue microarrays to big data analyses. Cancers (Basel). 14:61662022. View Article : Google Scholar : PubMed/NCBI

33 

Gorelik L and Flavell RA: Transforming growth factor-beta in T-cell biology. Nat Rev Immunol. 2:46–53. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Thomas DA and Massagué J: TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell. 8:369–380. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Hao Y, Baker D and Ten Dijke P: TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci. 20:27672019. View Article : Google Scholar : PubMed/NCBI

36 

Xu J, Lamouille S and Derynck R: TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 19:156–172. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Moustakas A and Heldin CH: Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 98:1512–1520. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Huang Y, Kim BYS, Chan CK, Hahn SM, Weissman IL and Jiang W: Improving immune-vascular crosstalk for cancer immunotherapy. Nat Rev Immunol. 18:195–203. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Franz L, Alessandrini L, Calvanese L, Crosetta G, Frigo AC and Marioni G: Angiogenesis, programmed death ligand 1 (PD-L1) and immune microenvironment association in laryngeal carcinoma. Pathology. 53:844–851. 2021. View Article : Google Scholar : PubMed/NCBI

40 

Bai Z, Zhou Y, Ye Z, Xiong J, Lan H and Wang F: Tumor-infiltrating lymphocytes in colorectal cancer: The fundamental indication and application on immunotherapy. Front Immunol. 12:8089642022. View Article : Google Scholar : PubMed/NCBI

41 

Bruni D, Angell HK and Galon J: The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 20:662–680. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Havel JJ, Chowell D and Chan TA: The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. Nat Rev Cancer. 19:133–150. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, et al: PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 515:568–571. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Miyamoto Y, Ogawa K, Ohuchi M, Tokunaga R and Baba H: Emerging evidence of immunotherapy for colorectal cancer. Ann Gastroenterol Surg. 7:216–224. 2022. View Article : Google Scholar : PubMed/NCBI

45 

Flecchia C, Zaanan A, Lahlou W, Basile D, Broudin C, Gallois C, Pilla L, Karoui M, Manceau G and Taieb J: MSI colorectal cancer, all you need to know. Clin Res Hepatol Gastroenterol. 46:1019832022. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dorjkhorloo G, Erkhem‑Ochir B, Shiraishi T, Sohda M, Okami H, Yamaguchi A, Shioi I, Komine C, Nakazawa N, Ozawa N, Ozawa N, et al: Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncol Lett 27: 104, 2024.
APA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A. ... Saeki, H. (2024). Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncology Letters, 27, 104. https://doi.org/10.3892/ol.2024.14237
MLA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27.3 (2024): 104.
Chicago
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27, no. 3 (2024): 104. https://doi.org/10.3892/ol.2024.14237
Copy and paste a formatted citation
x
Spandidos Publications style
Dorjkhorloo G, Erkhem‑Ochir B, Shiraishi T, Sohda M, Okami H, Yamaguchi A, Shioi I, Komine C, Nakazawa N, Ozawa N, Ozawa N, et al: Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncol Lett 27: 104, 2024.
APA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A. ... Saeki, H. (2024). Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer. Oncology Letters, 27, 104. https://doi.org/10.3892/ol.2024.14237
MLA
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27.3 (2024): 104.
Chicago
Dorjkhorloo, G., Erkhem‑Ochir, B., Shiraishi, T., Sohda, M., Okami, H., Yamaguchi, A., Shioi, I., Komine, C., Nakazawa, N., Ozawa, N., Shibasaki, Y., Okada, T., Osone, K., Sano, A., Sakai, M., Ogawa, H., Yokobori, T., Shirabe, K., Saeki, H."Prognostic value of a modified‑immune scoring system in patients with pathological T4 colorectal cancer". Oncology Letters 27, no. 3 (2024): 104. https://doi.org/10.3892/ol.2024.14237
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