Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Microwave ablation enhances the systemic immune response in patients with lung cancer

  • Authors:
    • Fuqi Ma
    • Yuhua Lin
    • Zhenhua Ni
    • Shiqiang Wang
    • Mengjie Zhang
    • Xiaoe Wang
    • Zhuhua Zhang
    • Xuming Luo
    • Xiayi Miao
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China, Central Lab, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 106
    |
    Published online on: January 18, 2024
       https://doi.org/10.3892/ol.2024.14239
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Microwave ablation (MWA) is a key alternative therapy to conventional surgery for the treatment of lung cancer. In addition to eliminating local tumors, MWA may promote antitumor immunological responses, such as abscopal effects in distant lesions. However, the intensity of MWA is limited and the underlying mechanisms are not well‑defined. The present study assessed the impact of MWA on immune cell subsets and cytokines in patients with lung cancer. A total of 45 patients with lung cancer who underwent percutaneous lung tumor MWA were enrolled. Peripheral blood samples were collected before and 24 h after MWA and changes in immune cell subsets [lymphocytes, CD3+, CD4+ and CD8+ T cells, B cells and natural killer (NK) cells] and serum cytokine levels (IL‑1β, IL‑2, IL‑4‑6, IL‑8, IL‑10, IL‑12p70, IL‑17A and F, IL‑22, TNF‑α, TNF‑β and IFN‑γ) were assessed by flow cytometry and ELISA. The number of total lymphocytes, CD4+ T and NK cells in the peripheral blood significantly decreased 24 h after MWA, while number of CD8+ T cells remained stable, leading to a higher proportion of CD8+ T cells. In addition, the serum levels of IL‑2, IL‑1β, IL‑6, IL‑12p70, IL‑22, TNF‑α and IFN‑γ were significantly increased 24 h after MWA, indicating a T helper 1 type immune response. The immune response in patients with advanced stage disease was comparable with patients in the early stage group; however, the number of total lymphocytes and CD3+ T cells significantly decreased and the ratio of CD4/CD8 and IL‑2 levels significantly increased. The early immune response after MWA may contribute to systemic antitumor immunity in patients with both early and advanced disease. Thus, MWA may exhibit potential as a local therapy and trigger abscopal effects in distant lesions in patients with lung cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Wu F, Wang L and Zhou C: Lung cancer in China: Current and prospect. Curr Opin Oncol. 33:40–46. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Gao S, Li N, Wang S, Zhang F, Wei W, Li N, Bi N, Wang Z and He J: Lung cancer in People's Republic of China. J Thorac Oncol. 15:1567–1576. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Brody H: Lung cancer. Nature. 587:S72020. View Article : Google Scholar : PubMed/NCBI

4 

Aokage K, Yoshida J, Hishida T, Tsuboi M, Saji H, Okada M, Suzuki K, Watanabe S and Asamura H: Limited resection for early-stage non-small cell lung cancer as function-preserving radical surgery: A review. Jpn J Clin Oncol. 47:7–11. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Ni Y, Xu H and Ye X: Image-guided percutaneous microwave ablation of early-stage non-small cell lung cancer. Asia Pac J Clin Oncol. 16:320–325. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Ryan MJ, Willatt J, Majdalany BS, Kielar AZ, Chong S, Ruma JA and Pandya A: Ablation techniques for primary and metastatic liver tumors. World J Hepatol. 8:191–199. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Vogl TJ, Nour-Eldin NA, Albrecht MH, Kaltenbach B, Hohenforst-Schmidt W, Lin H, Panahi B, Eichler K, Gruber-Rouh T and Roman A: Thermal ablation of lung tumors: Focus on microwave ablation. Rofo. 189:828–843. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Chan MV, Huo YR, Cao C and Ridley L: Survival outcomes for surgical resection versus CT-guided percutaneous ablation for stage I non-small cell lung cancer (NSCLC): A systematic review and meta-analysis. Eur Radiol. 31:5421–5433. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Liu Y, Dong Y, Kong L, Shi F, Zhu H and Yu J: Abscopal effect of radiotherapy combined with immune checkpoint inhibitors. J Hematol Oncol. 11:1042018. View Article : Google Scholar : PubMed/NCBI

10 

Chu KF and Dupuy DE: Thermal ablation of tumours: Biological mechanisms and advances in therapy. Nat Rev Cancer. 14:199–208. 2014. View Article : Google Scholar : PubMed/NCBI

11 

van den Bijgaart RJE, Eikelenboom DC, Hoogenboom M, Fütterer JJ, den Brok MH and Adema G J: Thermal and mechanical high-intensity focused ultrasound: Perspectives on tumor ablation, immune effects and combination strategies. Cancer Immunol Immunother. 66:247–258. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Vilinovszki O, Andratschke N, Huellner M, Curioni-Fontecedro A and Kroeze SGC: True abscopal effect in a patient with metastatic non-small cell lung cancer. Radiat Oncol. 16:1942021. View Article : Google Scholar : PubMed/NCBI

13 

Pierini S, Mishra A, Perales-Linares R, Uribe-Herranz M, Beghi S, Giglio A, Pustylnikov S, Costabile F, Rafail S, Amici A, et al: Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression. J Immunother Cancer. 9:e0016362021. View Article : Google Scholar : PubMed/NCBI

14 

Shao C, Yang M, Pan Y, Xie D, Chen B, Ren S and Zhou C: Case report: Abscopal effect of microwave ablation in a patient with advanced squamous NSCLC and resistance to immunotherapy. Front Immunol. 12:6967492021. View Article : Google Scholar : PubMed/NCBI

15 

Xu H, Sun W, Kong Y, Huang Y, Wei Z, Zhang L, Liang J and Ye X: Immune abscopal effect of microwave ablation for lung metastases of endometrial carcinoma. J Cancer Res Ther. 16:1718–1721. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Yu L, Xie H, Wang L, Cheng M, Liu J, Xu J, Wei Z, Ye X, Xie Q and Liang J: Microwave ablation induces abscopal effect via enhanced systemic antitumor immunity in colorectal cancer. Front Oncol. 13:11747132023. View Article : Google Scholar : PubMed/NCBI

17 

Song X, Li N, Liu Y, Wang Z, Wang T, Tan S, Li C, Qiu C, Gao L, Asano K, et al: CD169-positive macrophages enhance abscopal effect of radiofrequency ablation therapy in liver cancer. Transl Oncol. 15:1013062022. View Article : Google Scholar : PubMed/NCBI

18 

Khan SY, Melkus MW, Rasha F, Castro M, Chu V, Brandi L, Khan H, Gill HS, Pruitt K and Layeequr Rahman R: Tumor-infiltrating lymphocytes (TILs) as a biomarker of abscopal effect of cryoablation in breast cancer: A pilot study. Ann Surg Oncol. 29:2914–2925. 2022. View Article : Google Scholar : PubMed/NCBI

19 

He C, Huang X, Zhang Y, Lin X and Li S: T-cell activation and immune memory enhancement induced by irreversible electroporation in pancreatic cancer. Clin Transl Med. 10:e392020. View Article : Google Scholar : PubMed/NCBI

20 

Zhao Y, Zhang T, Wang Y, Lu D, Du J, Feng X, Zhou H, Liu N, Zhu H, Qin S, et al: ICAM-1 orchestrates the abscopal effect of tumor radiotherapy. Proc Natl Acad Sci USA. 118:e20103331182021. View Article : Google Scholar : PubMed/NCBI

21 

Zhang YS, Zhang YH, Li XJ, Hu TC, Chen WZ, Pan X, Chai HY and Ye YC: Bystander effect and abscopal effect in recurrent thymic carcinoma treated with carbon-ion radiation therapy: A case report. World J Clin Cases. 9:6538–6543. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Leuchte K, Staib E, Thelen M, Gödel P, Lechner A, Zentis P, Garcia-Marquez M, Waldschmidt D, Datta RR, Wahba R, et al: Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma. Cancer Immunol Immunother. 70:893–907. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Zhou W, Yu M, Mao X, Pan H, Tang X, Wang J, Che N, Xie H, Ling L, Zhao Y, et al: Landscape of the peripheral immune response induced by local microwave ablation in patients with breast cancer. Adv Sci (Weinh). 9:e22000332022. View Article : Google Scholar : PubMed/NCBI

24 

Zhang L, Zhang M, Wang J, Li Y, Wang T, Xia J, Feng B and Shen J: Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood. Front Immunol. 13:10691922022. View Article : Google Scholar : PubMed/NCBI

25 

Xu H, Tan X, Kong Y, Huang Y, Wei Z and Ye X: Microwave ablation of non-small cell lung cancer tumors changes plasma levels of cytokines IL-2 and IFN-γ. J Cancer Res Ther. 18:532–544. 2022. View Article : Google Scholar : PubMed/NCBI

26 

Puri S, Shafique M and Gray JE: Immune checkpoint inhibitors in early-stage and locally advanced non-small cell lung cancer. Curr Treat Options Oncol. 19:392018. View Article : Google Scholar : PubMed/NCBI

27 

Ye X, Fan W, Wang H, Wang J, Wang Z, Gu S, Feng W, Zhuang Y, Liu B, Li X, et al: Expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors (2018 edition). J Cancer Res Ther. 14:730–744. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Palussière J, Cazayus M, Cousin S, Cabart M, Chomy F, Catena V and Buy X: Is there a role for percutaneous ablation for early stage lung cancer? What Is the evidence? Curr Oncol Rep. 23:812021. View Article : Google Scholar : PubMed/NCBI

29 

Wang L, Xu J, Yu J and Liang P: Review of clinical tumor ablation advance in Asia. Int J Hyperthermia. 38:1639–1649. 2021. View Article : Google Scholar : PubMed/NCBI

30 

Flynn MJ, Sayed AA, Sharma R, Siddique A and Pinato DJ: Challenges and opportunities in the clinical development of immune checkpoint inhibitors for hepatocellular carcinoma. Hepatology. 69:2258–2270. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Rangamuwa K, Leong T, Weeden C, Asselin-Labat ML, Bozinovski S, Christie M, John T, Antippa P, Irving L and Steinfort D: Thermal ablation in non-small cell lung cancer: A review of treatment modalities and the evidence for combination with immune checkpoint inhibitors. Transl Lung Cancer Res. 10:2842–2857. 2021. View Article : Google Scholar : PubMed/NCBI

32 

den Brok MH, Sutmuller RP, van der Voort R, Bennink EJ, Figdor CG, Ruers TJ and Adema GJ: In situ tumor ablation creates an antigen source for the generation of antitumor immunity. Cancer Res. 64:4024–4029. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Wang K, Wang C, Jiang H, Zhang Y, Lin W, Mo J and Jin C: Combination of ablation and immunotherapy for hepatocellular carcinoma: Where we are and where to go. Front Immunol. 12:7927812021. View Article : Google Scholar : PubMed/NCBI

34 

Keisari Y: Tumor abolition and antitumor immunostimulation by physico-chemical tumor ablation. Front Biosci (Landmark Ed). 22:310–347. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Wei Z, Zhan X, Fan L, Ye X, Yang X, Huang G, Li W, Wang J, Han X, Meng M, et al: Programmed death-ligand 1 expression and CD8+ tumor-infiltrating lymphocytes in advanced non-small cell lung cancer treated with microwave ablation and chemotherapy. Int J Hyperthermia. 35:591–598. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Wu T, Sui GQ, Teng DK, Luo Q, Wang H and Lin YQ: Study on changes in immune function after microwave ablation of papillary thyroid microcarcinoma. Cancer Manag Res. 14:2861–2868. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Li L, Wang W, Pan H, Ma G, Shi X, Xie H, Liu X, Ding Q, Zhou W and Wang S: Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer. J Transl Med. 15:232017. View Article : Google Scholar : PubMed/NCBI

38 

Zhang H, Hou X, Cai H and Zhuang X: Effects of microwave ablation on T-cell subsets and cytokines of patients with hepatocellular carcinoma. Minim Invasive Ther Allied Technol. 26:207–211. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Volkó J, Kenesei Á, Zhang M, Várnai P, Mocsár G, Petrus MN, Jambrovics K, Balajthy Z, Müller G, Bodnár A, et al: IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies. Proc Natl Acad Sci USA. 116:21120–21130. 2019. View Article : Google Scholar : PubMed/NCBI

40 

Nguyen KG, Vrabel MR, Mantooth SM, Hopkins JJ, Wagner ES, Gabaldon TA and Zaharoff DA: Localized interleukin-12 for cancer immunotherapy. Front Immunol. 11:5755972020. View Article : Google Scholar : PubMed/NCBI

41 

Zhao J, Li Q, Muktiali M, Ren B, Hu Y, Li D, Li Z, Li D, Xie Y, Tao M and Liang R: Effect of microwave ablation treatment of hepatic malignancies on serum cytokine levels. BMC Cancer. 20:8122020. View Article : Google Scholar : PubMed/NCBI

42 

Zhou W, Yu M, Pan H, Qiu W, Wang H, Qian M, Che N, Zhang K, Mao X, Li L, et al: Microwave ablation induces Th1-type immune response with activation of ICOS pathway in early-stage breast cancer. J Immunother Cancer. 9:e0023432021. View Article : Google Scholar : PubMed/NCBI

43 

Bent EH, Millán-Barea LR, Zhuang I, Goulet DR, Fröse J and Hemann MT: Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Nat Commun. 12:62182021. View Article : Google Scholar : PubMed/NCBI

44 

Wu Y, Min J, Ge C, Shu J, Tian D, Yuan Y and Zhou D: Interleukin 22 in liver injury, inflammation and cancer. Int J Biol Sci. 16:2405–2413. 2020. View Article : Google Scholar : PubMed/NCBI

45 

Sun R, Gao DS, Shoush J and Lu B: The IL-1 family in tumorigenesis and antitumor immunity. Semin Cancer Biol. 86:280–295. 2022. View Article : Google Scholar : PubMed/NCBI

46 

Bent R, Moll L, Grabbe S and Bros M: Interleukin-1 beta-A friend or foe in malignancies? Int J Mol Sci. 19:21552018. View Article : Google Scholar : PubMed/NCBI

47 

Fisher DT, Appenheimer MM and Evans SS: The two faces of IL-6 in the tumor microenvironment. Semin Immunol. 26:38–47. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Hossein-Khannazer N, Zian Z, Bakkach J, Kamali AN, Hosseinzadeh R, Anka AU, Yazdani R and Azizi G: Features and roles of T helper 22 cells in immunological diseases and malignancies. Scand J Immunol. 93:e130302021. View Article : Google Scholar : PubMed/NCBI

49 

Perez LG, Kempski J, McGee HM, Pelzcar P, Agalioti T, Giannou A, Konczalla L, Brockmann L, Wahib R, Xu H, et al: TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer. Nat Commun. 11:26082020. View Article : Google Scholar : PubMed/NCBI

50 

Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD and Chandel NS: Serine metabolism supports macrophage IL-1β production. Cell Metab. 29:1003–1011.e4. 2019. View Article : Google Scholar : PubMed/NCBI

51 

Hirani D, Alvira CM, Danopoulos S, Milla C, Donato M, Tian L, Mohr J, Dinger K, Vohlen C, Selle J, et al: Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia. Eur Respir J. 59:20022482022. View Article : Google Scholar : PubMed/NCBI

52 

Hou Y, Zhu L, Tian H, Sun HX, Wang R, Zhang L and Zhao Y: IL-23-induced macrophage polarization and its pathological roles in mice with imiquimod-induced psoriasis. Protein Cell. 9:1027–1038. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Nishiga Y, Drainas AP, Baron M, Bhattacharya D, Barkal AA, Ahrari Y, Mancusi R, Ross JB, Takahashi N, Thomas A, et al: Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect. Nat Cancer. 3:1351–1366. 2022. View Article : Google Scholar : PubMed/NCBI

54 

Teijeira A, Garasa S, Ochoa MDC, Cirella A, Olivera I, Glez-Vaz J, Andueza MP, Migueliz I, Alvarez M, Rodriguez-Ruiz ME, et al: Differential Interleukin-8 thresholds for chemotaxis and netosis in human neutrophils. Eur J Immunol. 51:2274–2280. 2021. View Article : Google Scholar : PubMed/NCBI

55 

Yasuda K, Takeuchi Y and Hirota K: The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. 41:283–297. 2019. View Article : Google Scholar : PubMed/NCBI

56 

Liu T, Li S, Ying S, Tang S, Ding Y, Li Y, Qiao J and Fang H: The IL-23/IL-17 pathway in inflammatory skin diseases: From bench to bedside. Front Immunol. 11:5947352020. View Article : Google Scholar : PubMed/NCBI

57 

Zhou Y, Xu X, Ding J, Jing X, Wang F, Wang Y and Wang P: Dynamic changes of T-cell subsets and their relation with tumor recurrence after microwave ablation in patients with hepatocellular carcinoma. J Cancer Res Ther. 14:40–45. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Takaoka Y, Abe Y, Haraguchi R and Kito K: Lymphotoxin (TNF-beta). Nihon Rinsho. 68 (Suppl 7):S93–S95. 2010.(In Japanese).

59 

Chen Z, Huang Y, Hu Z, Zhao M, Li M, Bi G, Zheng Y, Liang J, Lu T, Jiang W, et al: Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma. Clin Transl Med. 11:e3502021. View Article : Google Scholar : PubMed/NCBI

60 

Gabrielson A, Wu Y, Wang H, Jiang J, Kallakury B, Gatalica Z, Reddy S, Kleiner D, Fishbein T, Johnson L, et al: Intratumoral CD3 and CD8 T-cell densities associated with relapse-free survival in HCC. Cancer Immunol Res. 4:419–430. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Huff WX, Kwon JH, Henriquez M, Fetcko K and Dey M: The evolving role of CD8+CD28− immunosenescent T cells in cancer immunology. Int J Mol Sci. 20:28102019. View Article : Google Scholar : PubMed/NCBI

62 

Ren Z, Zhang A, Sun Z, Liang Y, Ye J, Qiao J, Li B and Fu YX: Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity. J Clin Invest. 132:e1536042022. View Article : Google Scholar : PubMed/NCBI

63 

Tison A, Garaud S, Chiche L, Cornec D and Kostine M: Immune-checkpoint inhibitor use in patients with cancer and pre-existing autoimmune diseases. Nat Rev Rheumatol. 18:641–656. 2022. View Article : Google Scholar : PubMed/NCBI

64 

Jiang R and Sun B: IL-22 signaling in the tumor microenvironment. Adv Exp Med Biol. 1290:81–88. 2021. View Article : Google Scholar : PubMed/NCBI

65 

Rallis KS, Corrigan AE, Dadah H, Stanislovas J, Zamani P, Makker S, Szabados B and Sideris M: IL-10 in cancer: An essential thermostatic regulator between homeostatic immunity and inflammation-a comprehensive review. Future Oncol. 18:3349–3365. 2022. View Article : Google Scholar : PubMed/NCBI

66 

Qiao J, Liu Z, Dong C, Luan Y, Zhang A, Moore C, Fu K, Peng J, Wang Y, Ren Z, et al: Targeting tumors with IL-10 prevents dendritic cell-mediated CD8+ T cell apoptosis. Cancer Cell. 35:901–915.e4. 2019. View Article : Google Scholar : PubMed/NCBI

67 

Dromi SA, Walsh MP, Herby S, Traughber B, Xie J, Sharma KV, Sekhar KP, Luk A, Liewehr DJ, Dreher MR, et al: Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity. Radiology. 251:58–66. 2009. View Article : Google Scholar : PubMed/NCBI

68 

Faraoni EY, O'Brien BJ, Strickland LN, Osborn BK, Mota V, Chaney J, Atkins CL, Cen P, Rowe J, Cardenas J, et al: Radiofrequency ablation remodels the tumor microenvironment and promotes neutrophil-mediated abscopal immunomodulation in pancreatic cancer. Cancer Immunol Res. 11:4–12. 2023. View Article : Google Scholar : PubMed/NCBI

69 

Kanegasaki S and Tsuchiya T: Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3. Oncoimmunology. 3:e9589562014. View Article : Google Scholar : PubMed/NCBI

70 

Yin J, Dong J, Gao W and Wang Y: A case report of remarkable response to association of radiofrequency ablation with subsequent Atezolizumab in stage IV nonsmall cell lung cancer. Medicine (Baltimore). 97:e131122018. View Article : Google Scholar : PubMed/NCBI

71 

Yu W, Sun J, Wang T and Du Y: The effect of microwave ablation combined with anti-PD-1 monoclonal antibody on T cell subsets and long-term prognosis in patients suffering from non-small-cell lung cancer. Comput Math Methods Med. 2022:70954232022. View Article : Google Scholar : PubMed/NCBI

72 

Huang G, Li W, Meng M, Ni Y, Han X, Wang J, Zou Z, Zhang T, Dai J, Wei Z, et al: Synchronous microwave ablation combined with cisplatin intratumoral chemotherapy for large non-small cell lung cancer. Front Oncol. 12:9555452022. View Article : Google Scholar : PubMed/NCBI

73 

Feng K and Lu Y: Clinical analysis of systemic chemotherapy combined with microwave ablation in the treatment of lung cancer. Asian J Surg. 45:1107–1112. 2022. View Article : Google Scholar : PubMed/NCBI

74 

Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, Wang X, Peng C, Zhou C, Zhou L, et al: Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 10:54212019. View Article : Google Scholar : PubMed/NCBI

75 

Kutob L and Schneider F: Lung cancer staging. Surg Pathol Clin. 13:57–71. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ma F, Lin Y, Ni Z, Wang S, Zhang M, Wang X, Zhang Z, Luo X and Miao X: Microwave ablation enhances the systemic immune response in patients with lung cancer. Oncol Lett 27: 106, 2024.
APA
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X. ... Miao, X. (2024). Microwave ablation enhances the systemic immune response in patients with lung cancer. Oncology Letters, 27, 106. https://doi.org/10.3892/ol.2024.14239
MLA
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X., Zhang, Z., Luo, X., Miao, X."Microwave ablation enhances the systemic immune response in patients with lung cancer". Oncology Letters 27.3 (2024): 106.
Chicago
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X., Zhang, Z., Luo, X., Miao, X."Microwave ablation enhances the systemic immune response in patients with lung cancer". Oncology Letters 27, no. 3 (2024): 106. https://doi.org/10.3892/ol.2024.14239
Copy and paste a formatted citation
x
Spandidos Publications style
Ma F, Lin Y, Ni Z, Wang S, Zhang M, Wang X, Zhang Z, Luo X and Miao X: Microwave ablation enhances the systemic immune response in patients with lung cancer. Oncol Lett 27: 106, 2024.
APA
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X. ... Miao, X. (2024). Microwave ablation enhances the systemic immune response in patients with lung cancer. Oncology Letters, 27, 106. https://doi.org/10.3892/ol.2024.14239
MLA
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X., Zhang, Z., Luo, X., Miao, X."Microwave ablation enhances the systemic immune response in patients with lung cancer". Oncology Letters 27.3 (2024): 106.
Chicago
Ma, F., Lin, Y., Ni, Z., Wang, S., Zhang, M., Wang, X., Zhang, Z., Luo, X., Miao, X."Microwave ablation enhances the systemic immune response in patients with lung cancer". Oncology Letters 27, no. 3 (2024): 106. https://doi.org/10.3892/ol.2024.14239
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team