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Article Open Access

PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma

  • Authors:
    • Jiaqi Yi
    • Xuehua Luo
    • Weijian Huang
    • Weijun Yang
    • Yan Qi
    • Jun He
    • Huijun Xie
  • View Affiliations / Copyright

    Affiliations: College of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Institute of Laboratory Animal Science, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Market Research and Development, China Animal Husbandry Group, Beijing 100000, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 109
    |
    Published online on: January 19, 2024
       https://doi.org/10.3892/ol.2024.14242
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Abstract

Hepatocellular carcinoma (HCC), a common type of liver cancer, is increasing in incidence worldwide. An early diagnosis of hepatocellular carcinoma (HCC) is still challenging: Currently, few biomarkers are available to diagnose the early stage of HCC, therefore, additional prognostic biomarkers are required to identify potential risk factors. The present study analyzed gene expression levels of HCC tissue samples and the protein expression levels obtained from the GSE46408 HCC dataset using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The metabolically associated differentially expressed genes (DEGs), including DEGs involved in the glucose metabolism pathway, were selected for further analysis. Phosphoglycerate kinase 1 (PGK1), a glycolytic enzyme, was determined as a potential prognostic biomarker through Kaplan‑Meier curve and clinical association variable analyses. This was also verified based on the expression levels of PGK1 in tumor tissue and protein expression levels in several liver cancer cell lines. PGK1 mRNA demonstrated a high level of expression in HCC tissue and was significantly associated with a poor prognosis, showing a negative association with survival time. In addition, as an independent risk factor, PGK1 may potentially be a valuable prognostic biomarker for patients with HCC. Furthermore, expression of PGK1 was associated with the early stages (stage I and T1) of HCC. Moreover, PGK1 mRNA expression levels demonstrated a positive association with progression of liver cancer. The results suggested that PGK1 mRNA may be involved in the degree of HCC malignancy and may be a future potential prognostic biomarker for HCC progression.
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Copy and paste a formatted citation
Spandidos Publications style
Yi J, Luo X, Huang W, Yang W, Qi Y, He J and Xie H: PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma. Oncol Lett 27: 109, 2024.
APA
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., & Xie, H. (2024). PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma. Oncology Letters, 27, 109. https://doi.org/10.3892/ol.2024.14242
MLA
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., Xie, H."PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma". Oncology Letters 27.3 (2024): 109.
Chicago
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., Xie, H."PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma". Oncology Letters 27, no. 3 (2024): 109. https://doi.org/10.3892/ol.2024.14242
Copy and paste a formatted citation
x
Spandidos Publications style
Yi J, Luo X, Huang W, Yang W, Qi Y, He J and Xie H: PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma. Oncol Lett 27: 109, 2024.
APA
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., & Xie, H. (2024). PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma. Oncology Letters, 27, 109. https://doi.org/10.3892/ol.2024.14242
MLA
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., Xie, H."PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma". Oncology Letters 27.3 (2024): 109.
Chicago
Yi, J., Luo, X., Huang, W., Yang, W., Qi, Y., He, J., Xie, H."PGK1 is a potential biomarker for early diagnosis and prognosis of hepatocellular carcinoma". Oncology Letters 27, no. 3 (2024): 109. https://doi.org/10.3892/ol.2024.14242
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