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Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer

  • Authors:
    • Shinichi Kinami
    • Daisuke Kaida
    • Koichi Okamoto
    • Takashi Fujimura
    • Yasuo Iida
    • Noriyuki Inaki
    • Hiroyuki Takamura
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Kanazawa Medical University, Kahoku, Ishikawa 920‑0293, Japan, Department of Surgery, Toyama City Hospital, Toyama, Toyama 939‑8511, Japan, Department of Mathematics, Division of General Education, Kanazawa Medical University, Kahoku, Ishikawa 920‑0293, Japan, Department of Gastrointestinal Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan
    Copyright: © Kinami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 115
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    Published online on: January 22, 2024
       https://doi.org/10.3892/ol.2024.14248
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Abstract

Segmental gastrectomy, mini‑distal gastrectomy and local resection of the stomach are function‑preserving curative gastrectomies (FPGs), which are used to treat gastric cancer in specialized centers. These surgical options are less invasive and can alleviate postgastrectomy symptoms more than standard gastrectomy; however, their association with prognosis remains to be fully elucidated. The present study aimed to compare the survival prognosis of patients diagnosed as node‑negative by sentinel node biopsy (SNB) treated via FPG with reduced lymph node dissection with that of patients who underwent guideline gastrectomy (GL). This retrospective study was conducted between April 1999 and March 2016. The inclusion criteria were a diagnosis of gastric cancer type 0, of ≤5 cm, located in L or M areas, and pT1N0. Patients who underwent distal gastrectomy and pylorus‑preserving gastrectomy were included as controls in the GL group. Among the 146 and 300 patients in the FPG and GL groups, respectively, only 1 patient in the GL group experienced recurrence. The overall survival (OS) of the FPG group was 96.6% at 5 years and 92.5% at 10 years, which was significantly higher than that of the GL group (P<0.05). In addition, the cumulative incidence of non‑cancer‑related deaths, especially pulmonary diseases, was lower in the FPG group than that in the GL group (P<0.05). Notably, the OS and non‑cancer death rate in the FPG group remained significantly better after propensity score‑matching analysis. In conclusion, for early gastric cancer located in M or L areas, patients treated via FPG guided by SNB have a better prognosis and fewer deaths caused by respiratory disease than those treated via GL. The present clinical trial was registered under the following trial registration numbers: UMIN000010154 (2013/3/4), UMIN000023828 (2016/8/29), jRCTs041180006 (2018/10/9).
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Copy and paste a formatted citation
Spandidos Publications style
Kinami S, Kaida D, Okamoto K, Fujimura T, Iida Y, Inaki N and Takamura H: Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer. Oncol Lett 27: 115, 2024.
APA
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., & Takamura, H. (2024). Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer. Oncology Letters, 27, 115. https://doi.org/10.3892/ol.2024.14248
MLA
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., Takamura, H."Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer". Oncology Letters 27.3 (2024): 115.
Chicago
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., Takamura, H."Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer". Oncology Letters 27, no. 3 (2024): 115. https://doi.org/10.3892/ol.2024.14248
Copy and paste a formatted citation
x
Spandidos Publications style
Kinami S, Kaida D, Okamoto K, Fujimura T, Iida Y, Inaki N and Takamura H: Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer. Oncol Lett 27: 115, 2024.
APA
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., & Takamura, H. (2024). Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer. Oncology Letters, 27, 115. https://doi.org/10.3892/ol.2024.14248
MLA
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., Takamura, H."Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer". Oncology Letters 27.3 (2024): 115.
Chicago
Kinami, S., Kaida, D., Okamoto, K., Fujimura, T., Iida, Y., Inaki, N., Takamura, H."Long‑term survival prognosis of function‑preserving curative gastrectomy for early gastric cancer". Oncology Letters 27, no. 3 (2024): 115. https://doi.org/10.3892/ol.2024.14248
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