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Article

Prognostic value of moderate or massive ascites in patients with advanced gastric cancer

  • Authors:
    • Naoto Iwai
    • Tomoya Ohara
    • Takashi Okuda
    • Kohei Oka
    • Hiroaki Sakai
    • Mariko Kajiwara-Kubota
    • Toshifumi Tsuji
    • Junichi Sakagami
    • Keizo Kagawa
    • Toshifumi Doi
    • Ken Inoue
    • Osamu Dohi
    • Naohisa Yoshida
    • Kazuhiko Uchiyama
    • Takeshi Ishikawa
    • Tomohisa Takagi
    • Hideyuki Konishi
    • Yoshito Itoh
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Fukuchiyama, Kyoto 620-8505, Japan, Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Article Number: 116
    |
    Published online on: January 22, 2024
       https://doi.org/10.3892/ol.2024.14249
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Abstract

Advanced gastric cancer is a highly aggressive malignancy. The available literature does not provide the prognostic value of ascites based on their degree, because most clinical trials exclude patients who present with massive ascites. Therefore, this study examined whether the presence or degree of ascites has a prognostic value in 124 patients with advanced gastric cancer. The degree of ascites was assessed using computed tomography and classified as none, small, moderate or massive. The overall survival (OS) was compared based on the presence or degree of ascites. Furthermore, a Cox proportional hazards analysis was performed to ascertain the predictors of OS. The cumulative 1‑year and 2‑year OS rates in patients without ascites were 43.5 and 20.2%, respectively, whereas those in patients with ascites were 29.1 and 13.6%, respectively (P=0.116). The cumulative 1‑year and 2‑year OS rates in patients without moderate or massive ascites were 39.5 and 20.9%, respectively; however, those in patients with moderate or massive ascites were 28.0 and 4.0%, respectively (P=0.027). Multivariate analysis showed that diffuse‑type [hazard ratio (HR), 1.532; 95% confidence interval (CI), 1.002‑2.343; P=0.049], moderate or massive ascites (HR, 2.153; 95% CI, 1.301‑3.564; P=0.003) and chemotherapy (HR, 0.189; 95% CI, 0.101‑0.352; P<0.001) were significant predictive factors of OS. In conclusion, the present study indicated that moderate or massive ascites may influence the OS of patients with advanced gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Iwai N, Ohara T, Okuda T, Oka K, Sakai H, Kajiwara-Kubota M, Tsuji T, Sakagami J, Kagawa K, Doi T, Doi T, et al: Prognostic value of moderate or massive ascites in patients with advanced gastric cancer. Oncol Lett 27: 116, 2024.
APA
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M. ... Itoh, Y. (2024). Prognostic value of moderate or massive ascites in patients with advanced gastric cancer. Oncology Letters, 27, 116. https://doi.org/10.3892/ol.2024.14249
MLA
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M., Tsuji, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Prognostic value of moderate or massive ascites in patients with advanced gastric cancer". Oncology Letters 27.3 (2024): 116.
Chicago
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M., Tsuji, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Prognostic value of moderate or massive ascites in patients with advanced gastric cancer". Oncology Letters 27, no. 3 (2024): 116. https://doi.org/10.3892/ol.2024.14249
Copy and paste a formatted citation
x
Spandidos Publications style
Iwai N, Ohara T, Okuda T, Oka K, Sakai H, Kajiwara-Kubota M, Tsuji T, Sakagami J, Kagawa K, Doi T, Doi T, et al: Prognostic value of moderate or massive ascites in patients with advanced gastric cancer. Oncol Lett 27: 116, 2024.
APA
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M. ... Itoh, Y. (2024). Prognostic value of moderate or massive ascites in patients with advanced gastric cancer. Oncology Letters, 27, 116. https://doi.org/10.3892/ol.2024.14249
MLA
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M., Tsuji, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Prognostic value of moderate or massive ascites in patients with advanced gastric cancer". Oncology Letters 27.3 (2024): 116.
Chicago
Iwai, N., Ohara, T., Okuda, T., Oka, K., Sakai, H., Kajiwara-Kubota, M., Tsuji, T., Sakagami, J., Kagawa, K., Doi, T., Inoue, K., Dohi, O., Yoshida, N., Uchiyama, K., Ishikawa, T., Takagi, T., Konishi, H., Itoh, Y."Prognostic value of moderate or massive ascites in patients with advanced gastric cancer". Oncology Letters 27, no. 3 (2024): 116. https://doi.org/10.3892/ol.2024.14249
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