Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2024 Volume 27 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma

  • Authors:
    • Terufumi Yoshida
    • Kazuko Sakai
    • Masaki Kaibori
    • Mitsuaki Ishida
    • Shogo Tanaka
    • Shoji Kubo
    • Takuya Nakai
    • Marco A. De Velasco
    • Hideyuki Matsushima
    • Koji Tsuta
    • Mitsugu Sekimoto
    • Kazuto Nishio
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan, Department of Genome Biology, Kindai University Faculty of Medicine, Osakasayama, Osaka 589‑8511, Japan, Department of Pathology, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka 569‑8686, Japan, Department of Hepato‑Biliary‑Pancreatic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Osaka 545‑8585, Japan, Department of Surgery, Kindai University Faculty of Medicine, Osakasayama, Osaka 589‑8511, Japan, Department of Pathology, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
    Copyright: © Yoshida et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 124
    |
    Published online on: January 26, 2024
       https://doi.org/10.3892/ol.2024.14257
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sarcomatoid hepatocellular carcinoma (SHCC) is a rare and highly lethal subtype of HCC. The present study aimed to explore the unique markers of SHCC using whole gene expression analysis. Subsequently, gene expression analysis was performed using five sarcomatoid and seven carcinomatoid components of seven tissues from patients with SHCC. The results demonstrated a significant downregulation of polybromo 1 (PBRM1) gene expression in the sarcomatoid components. Immunohistochemical staining also indicated a decreased expression of PBRM1 in the sarcomatoid components. Moreover, gene ontology enrichment analysis revealed that most of the 336 differentially expressed genes between the sarcomatoid and carcinomatoid components were involved in functions associated with DNA replication and histone methylation, which was consistent with the loss of function of PBRM1 which encodes Switch/sucrose‑non‑fermentable chromatin remodeling complex protein. Therefore, the results of the present study suggested that PBRM1 may be a candidate biomarker for the evaluation of SHCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Roberts LR, Sirlin CB, Zaiem F, Almasri J, Prokop LJ, Heimbach JK, Murad MH and Mohammed K: Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis. Hepatology. 67:401–421. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Torbenson MS: Morphologic subtypes of hepatocellular carcinoma. Gastroenterol Clin North Am. 46:365–391. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Watanabe Y, Matsumoto N, Ogawa M, Moriyama M and Sugitani M: Sarcomatoid hepatocellular carcinoma with spontaneous intraperitoneal bleeding. Intern Med. 54:1613–1617. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Lv TR, Hu HJ, Regmi P, Liu F and Li FY: Sarcomatoid hepatocellular carcinoma versus conventional hepatocellular carcinoma: A systematic review and meta-analysis. J Cancer Res Clin Oncol. 148:1685–1696. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Benusiglio PR, Couve S, Gilbert-Dussardier B, Deveaux S, Le Jeune H, Da Costa M, Fromont G, Memeteau F, Yacoub M, Coupier I, et al: A germline mutation in PBRM1 predisposes to renal cell carcinoma. J Med Genet. 52:426–430. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Hwang S, Lee SG, Lee YJ, Ahn CS, Kim KH, Park KM, Moon KM, Moon DB, Ha TY, Yu ES and Choi GW: Prognostic impact of sarcomatous change of hepatocellular carcinoma in patients undergoing liver resection and liver transplantation. J Gastrointest Surg. 12:718–724. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Liao SH, Su TH, Jeng YM, Liang PC, Chen DS, Chen CH and Kao JH: Clinical manifestations and outcomes of patients with sarcomatoid hepatocellular carcinoma. Hepatology. 69:209–221. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Kojiro M, Sugihara S, Kakizoe S, Nakashima O and Kiyomatsu K: Hepatocellular carcinoma with sarcomatous change: A special reference to the relationship with anticancer therapy. Cancer Chemother Pharmacol. 23 (Suppl):S4–S8. 1989. View Article : Google Scholar : PubMed/NCBI

10 

Lu J, Xiong XZ, Li FY, Ye H, Lin YX, Zhou RX, Cai YL, Jin YW and Cheng NS: Prognostic significance of sarcomatous change in patients with hepatocellular carcinoma after surgical resection. Ann Surg Oncol. 22 (Suppl 3):S1048–S1056. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Calderaro J, Couchy G, Imbeaud S, Amaddeo G, Letouzé E, Blanc JF, Laurent C, Hajji Y, Azoulay D, Bioulac-Sage P, et al: Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. J Hepatol. 67:727–738. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Morisue R, Kojima M, Suzuki T, Nakatsura T, Ojima H, Watanabe R, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, et al: Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma: Clinicopathologic, transcriptomic and immunologic analyses. Int J Cancer. 149:546–560. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Zhang C, Feng S, Tu Z, Sun J, Rui T, Zhang X, Huang H, Ling Q and Zheng S: Sarcomatoid hepatocellular carcinoma: From clinical features to cancer genome. Cancer Med. 10:6227–6238. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Ministry of Education Culture, Sports, Science and Technology, Ministry of Health, Labour and Welfare, and Ministry of Economy, Trade and Industry, . Ethical Guidelines for Medical and Biological Research Involving Human Subjects. https://www.mhlw.go.jp/content/001077424.pdfJanuary 19–2024(In Japanese).

15 

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C and Chanda SK: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 10:15232019. View Article : Google Scholar : PubMed/NCBI

16 

De Velasco MA, Kura Y, Ando N, Sako N, Banno E, Fujita K, Nozawa M, Yoshimura K, Sakai K, Yoshikawa K, et al: Context-Specific efficacy of apalutamide therapy in preclinical models of pten-deficient prostate cancer. Cancers (Basel). 13:39752021. View Article : Google Scholar : PubMed/NCBI

17 

Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, Leng N, Pavía-Jiménez A, Wang S, Yamasaki T, Zhrebker L, Sivanand S, Spence P, et al: BAP1 loss defines a new class of renal cell carcinoma. Nat Genet. 44:751–759. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bankhead P, Loughrey MB, Fernandez JA, Dombrowski Y, McArt DG, Dunne PD, McQuaid S, Gray RT, Murray LJ, Coleman HG, et al: QuPath: Open source software for digital pathology image analysis. Sci Rep. 7:168782017. View Article : Google Scholar : PubMed/NCBI

19 

Eckel-Passow JE, Serie DJ, Cheville JC, Ho TH, Kapur P, Brugarolas J, Thompson RH, Leibovich BC, Kwon ED, Joseph RW and Parker AS: BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: Tumor heterogeneity and concordance with paired primary tumor. BMC Urol. 17:192017. View Article : Google Scholar : PubMed/NCBI

20 

Carril-Ajuria L, Santos M, Roldan-Romero JM, Rodriguez-Antona C and de Velasco G: Prognostic and predictive value of PBRM1 in clear cell renal cell carcinoma. Cancers (Basel). 12:162019. View Article : Google Scholar : PubMed/NCBI

21 

Brugarolas J: PBRM1 and BAP1 as novel targets for renal cell carcinoma. Cancer J. 19:324–332. 2013. View Article : Google Scholar : PubMed/NCBI

22 

da Costa WH, Rezende M, Carneiro FC, Rocha RM, da Cunha IW, Carraro DM, Guimaraes GC and de Cassio Zequi S: Polybromo-1 (PBRM1), a SWI/SNF complex subunit is a prognostic marker in clear cell renal cell carcinoma. BJU Int. 113:E157–E163. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Porter EG and Dykhuizen EC: Individual bromodomains of polybromo-1 contribute to chromatin association and tumor suppression in clear cell renal carcinoma. J Biol Chem. 292:2601–2610. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, et al: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 364:2517–2526. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Pawlowski R, Muhl SM, Sulser T, Krek W, Moch H and Schraml P: Loss of PBRM1 expression is associated with renal cell carcinoma progression. Int J Cancer. 132:E11–E17. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Burrows AE, Smogorzewska A and Elledge SJ: Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci USA. 107:14280–14285. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Macher-Goeppinger S, Keith M, Tagscherer KE, Singer S, Winkler J, Hofmann TG, Pahernik S, Duensing S, Hohenfellner M, Kopitz J, et al: PBRM1 (BAF180) protein is functionally regulated by p53-induced protein degradation in renal cell carcinomas. J Pathol. 237:460–471. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Xia W, Nagase S, Montia AG, Kalachikov SM, Keniry M, Su T, Memeo L, Hibshoosh H and Parsons R: BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer. Cancer Res. 68:1667–1674. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Liu T, Xia Q, Zhang H, Wang Z, Yang W, Gu X, Hou T, Chen Y, Pei X, Zhu G, et al: CCL5-dependent mast cell infiltration into the tumor microenvironment in clear cell renal cell carcinoma patients. Aging (Albany NY). 12:21809–21836. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Guo C, Yang G, Khun K, Kong X, Levy D, Lee P and Melamed J: Activation of Stat3 in renal tumors. Am J Transl Res. 1:283–290. 2009.PubMed/NCBI

31 

Horiguchi A, Oya M, Shimada T, Uchida A, Marumo K and Murai M: Activation of signal transducer and activator of transcription 3 in renal cell carcinoma: A study of incidence and its association with pathological features and clinical outcome. J Urol. 168:762–765. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Hsu CS, Chao YC, Lin HH, Chen DS and Kao JH: Systematic Review: Impact of interferon-based therapy on HCV-related hepatocellular carcinoma. Sci Rep. 5:99542015. View Article : Google Scholar : PubMed/NCBI

33 

Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, et al: Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 359:801–806. 2018. View Article : Google Scholar : PubMed/NCBI

34 

da Costa WH, da Cunha IW, Fares AF, Bezerra SM, Shultz L, Clavijo DA, da Silva DV, Netto GJ, Guimaraes GC and Cassio Zequi S: Prognostic impact of concomitant loss of PBRM1 and BAP1 protein expression in early stages of clear cell renal cell carcinoma. Urol Oncol. 36:243 e1–243 e8. 2018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yoshida T, Sakai K, Kaibori M, Ishida M, Tanaka S, Kubo S, Nakai T, De Velasco MA, Matsushima H, Tsuta K, Tsuta K, et al: Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncol Lett 27: 124, 2024.
APA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S. ... Nishio, K. (2024). Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncology Letters, 27, 124. https://doi.org/10.3892/ol.2024.14257
MLA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27.3 (2024): 124.
Chicago
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27, no. 3 (2024): 124. https://doi.org/10.3892/ol.2024.14257
Copy and paste a formatted citation
x
Spandidos Publications style
Yoshida T, Sakai K, Kaibori M, Ishida M, Tanaka S, Kubo S, Nakai T, De Velasco MA, Matsushima H, Tsuta K, Tsuta K, et al: Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncol Lett 27: 124, 2024.
APA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S. ... Nishio, K. (2024). Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma. Oncology Letters, 27, 124. https://doi.org/10.3892/ol.2024.14257
MLA
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27.3 (2024): 124.
Chicago
Yoshida, T., Sakai, K., Kaibori, M., Ishida, M., Tanaka, S., Kubo, S., Nakai, T., De Velasco, M. A., Matsushima, H., Tsuta, K., Sekimoto, M., Nishio, K."Downregulated expression of PBRM1 in sarcomatoid hepatocellular carcinoma". Oncology Letters 27, no. 3 (2024): 124. https://doi.org/10.3892/ol.2024.14257
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team