Two tumor types in a unilateral testis in a patient with severe oligozoospermia and a history of cryptorchidism surgery: A case report

Tsujioka,Hiroki; Uemura,Kei-Ichiro; Osaka,Akiyoshi; Iwahata,Toshiyuki; Fujii,Akiko; Ban,Shinichi; Okada,Hiroshi; Saito,Kazutaka

doi:10.3892/ol.2024.14262

March-2024 Volume 27 Issue 3

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March-2024 Volume 27 Issue 3

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Two tumor types in a unilateral testis in a patient with severe oligozoospermia and a history of cryptorchidism surgery: A case report

Authors:
- Hiroki Tsujioka
- Kei-Ichiro Uemura
- Akiyoshi Osaka
- Toshiyuki Iwahata
- Akiko Fujii
- Shinichi Ban
- Hiroshi Okada
- Kazutaka Saito
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Affiliations: Department of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama 343‑8555, Japan, Department of Pathology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama 343‑8555, Japan

Copyright: © Tsujioka et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 130
|
Published online on: January 30, 2024

https://doi.org/10.3892/ol.2024.14262
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Abstract

Testicular cancer, the most common cancer among young male adults, is associated with infertility. A 38‑year‑old male patient was admitted to Dokkyo Medical University Saitama Medical Center, Japan, with infertility associated with severe oligozoospermia. Scrotal ultrasonography revealed two distinct tumors in the left testis: A mass with abundant blood flow on the cranial side and a mass with poor blood flow on the caudal side. Additional analysis revealed mild elevation of intact human chorionic gonadotropin (hCG) levels (tumor marker level assessment), high testosterone and low luteinizing hormone and follicle‑stimulating hormone levels (hormonal level assessment) and severe oligoasthenozoospermia (semen assessment). The preoperative diagnosis was left‑sided testicular cancer and severe oligoasthenozoospermia and the patient underwent left high orchiectomy and oncological testicular sperm extraction. Based on the pathological assessment, the cranial tumor was diagnosed as a seminoma with syncytiotrophoblastic cells, whereas the caudal tumor had only scar tissue with germ cell neoplasia in situ in the adjacent parenchyma. Following surgery, intact hCG and hormone levels of the patient were normalized, and the semen parameters (semen volume, sperm density, and motility) improved dramatically. To the best of our knowledge, the present case is the first report of two types of testicular tumor in a unilateral testis in a patient with a history of cryptorchidism surgery. The present case demonstrated that scrotal ultrasonography should be performed in patients with abnormal semen results to rule out testicular tumors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Two tumor types in a unilateral testis in a patient with severe oligozoospermia and a history of cryptorchidism surgery: A case report

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