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Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs

  • Authors:
    • Xiaona Su
    • Ci Zhou
    • Shu Chen
    • Qiang Ma
    • He Xiao
    • Qian Chen
    • Hua Zou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Daping Hospital, Army Medical Center of People's Liberation Army (Chongqing Daping Hospital), Chongqing 400042, P.R. China, Institute of Surgery Research, Daping Hospital, Army Medical Center of People's Liberation Army (Chongqing Daping Hospital), Chongqing 400042, P.R. China, Department of Pathology, Daping Hospital, Army Medical Center of People's Liberation Army (Chongqing Daping Hospital), Chongqing 400042, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 131
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    Published online on: January 30, 2024
       https://doi.org/10.3892/ol.2024.14264
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Abstract

Immune checkpoint inhibitors (ICIs) combined with platinum‑containing chemotherapy are recommended as the standard first‑line treatment for non‑small cell lung cancer (NSCLC). However, specific prognostic markers for this combination therapy are yet to be identified. Evaluation of circulating tumor cells (CTCs) and cell surface programmed death‑ligand 1 (PD‑L1) exhibits potential in predicting the efficacy of the aforementioned combination therapy. Thus, the present study aimed to evaluate the prognostic value of CTC PD‑L1 testing and other clinical characteristics in patients with NSCLC treated with combination therapy as first‑line treatment. In total, 40 patients with advanced NSCLC were included in the present study, and all patients underwent CTC PD‑L1 testing at initial diagnosis to determine the association between CTC PD‑L1 and tissue PD‑L1. The prognostic value of CTC PD‑L1 and the baseline characteristics of 26 patients with NSCLC were analyzed, and the prognostic values of changes in CTC PD‑L1 and baseline characteristics during 6 months of treatment were further explored. Results of the present study demonstrated that there was no association between CTC PD‑L1 and tissue PD‑L1 levels. After 6 months of combination therapy, tumor shrinkage, CYFA19 levels and treatment maintenance were associated with progression‑free survival (PFS) of patients. Notably, CTC PD‑L1 and tissue PD‑L1 levels, TNM stage, nutritional score, inflammation score and other blood indicators were not associated with PFS. In conclusion, the evaluation of CTCs and CTC PD‑L1 suggested that undetectable CTCs at 6 months of NSCLC treatment are associated with a good prognosis. In addition, negative CTC PD‑L1 expression may change to positive CTC PD‑L1 expression in line with disease progression, and this may be indicative of poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Su X, Zhou C, Chen S, Ma Q, Xiao H, Chen Q and Zou H: Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs. Oncol Lett 27: 131, 2024.
APA
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., & Zou, H. (2024). Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs. Oncology Letters, 27, 131. https://doi.org/10.3892/ol.2024.14264
MLA
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., Zou, H."Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs". Oncology Letters 27.3 (2024): 131.
Chicago
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., Zou, H."Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs". Oncology Letters 27, no. 3 (2024): 131. https://doi.org/10.3892/ol.2024.14264
Copy and paste a formatted citation
x
Spandidos Publications style
Su X, Zhou C, Chen S, Ma Q, Xiao H, Chen Q and Zou H: Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs. Oncol Lett 27: 131, 2024.
APA
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., & Zou, H. (2024). Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs. Oncology Letters, 27, 131. https://doi.org/10.3892/ol.2024.14264
MLA
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., Zou, H."Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs". Oncology Letters 27.3 (2024): 131.
Chicago
Su, X., Zhou, C., Chen, S., Ma, Q., Xiao, H., Chen, Q., Zou, H."Prognosis value of circulating tumor cell PD‑L1 and baseline characteristics in patients with NSCLC treated with immune checkpoint inhibitors plus platinum‑containing drugs". Oncology Letters 27, no. 3 (2024): 131. https://doi.org/10.3892/ol.2024.14264
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