Primary lymphoplasmacytic lymphoma of the larynx mimicking extramedullary plasmacytoma: A case report

Miyamori,Moeko; Ichikawa,Takaya; Inamura,Naoya; Takekawa,Hana; Sakoda,Kento; Yamada,Kazuyuki; Suzuki,Fumiyuki

doi:10.3892/ol.2024.14265

March-2024 Volume 27 Issue 3

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March-2024 Volume 27 Issue 3

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Case Report Open Access

Primary lymphoplasmacytic lymphoma of the larynx mimicking extramedullary plasmacytoma: A case report

Authors:
- Moeko Miyamori
- Takaya Ichikawa
- Naoya Inamura
- Hana Takekawa
- Kento Sakoda
- Kazuyuki Yamada
- Fumiyuki Suzuki
View Affiliations / Copyright

Affiliations: Department of Otorhinolaryngology and Thyroid Surgery, Sapporo City General Hospital, Sapporo, Hokkaido 060‑8604, Japan, Department of Hematology, Sapporo City General Hospital, Sapporo, Hokkaido 060‑8604, Japan, Department of Otolaryngology‑Head and Neck Surgery, Hokkaido University, Sapporo, Hokkaido 060‑0808, Japan

Copyright: © Miyamori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 132
|
Published online on: January 30, 2024

https://doi.org/10.3892/ol.2024.14265
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Abstract

Primary haematological neoplasms of the larynx are uncommon; therefore, information regarding their epidemiology is limited and the diagnosis of histological types requires careful consideration. The current study describes the case of a 72‑year‑old male patient with primary laryngeal lymphoplasmacytic lymphoma (LPL) that was difficult to distinguish from plasmacytoma. Imaging examinations of the neck revealed a mass in the right laryngeal folds, 25x12x25 mm in size, which was surgically resected by direct laryngoscopy. Histopathologically, the mass showed diffuse proliferation of plasma cells with CD138 (+) and IgG (+) in the submucosal stroma. Flow cytometry revealed the tumour was positive for CD19 and negative for CD56. Based on these findings, the final diagnosis was confirmed as LPL, albeit similar to plasmacytoma regarding phenotypic features. There was no evidence of local or systemic recurrence following surgery, and the patient has been followed up without additional treatment. This case highlights the unique presentation of laryngeal lymphoma mimicking solitary plasmacytoma. The key factor in the diagnosis was the expression pattern of surface antigen markers.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary lymphoplasmacytic lymphoma of the larynx mimicking extramedullary plasmacytoma: A case report

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Abstract

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