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Article

Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors

  • Authors:
    • Yi Zeng
    • Yudong Ling
    • Xiaojiang Chen
    • Chao Ding
    • Yukai Jin
    • Shoucheng Feng
    • Zhenchong Chen
    • Jianrong Guo
    • Haibo Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Gastric Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
  • Article Number: 133
    |
    Published online on: January 31, 2024
       https://doi.org/10.3892/ol.2024.14266
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Abstract

For patients with gastrointestinal stromal tumors (GISTs) and liver metastases, there is still debate about whether radiofrequency ablation (RFA) or hepatectomy is preferable. The present study aimed to compare the clinical outcomes of RFA with hepatectomy in patients with GISTs and liver metastases. The present retrospective study consisted of a cohort of 43 patients who had been diagnosed with liver metastases from GISTs between January 2010 and December 2022. The study included 18 patients who received RFA combined with tyrosine kinase inhibitor (TKI) therapy (RFA group) and 25 patients who underwent hepatectomy combined with TKI therapy (hepatectomy group). For the patients with liver metastases, the progression‑free survival (PFS) rates at 1, 3 and 5 years were 66.5, 38.2 and 33.9%, respectively. Notably, patients in the hepatectomy group exhibited significantly improved PFS times compared with those in the RFA group (median PFS, 42.7 months vs. 14.3 months; P=0.034). Furthermore, the time to imatinib treatment failure (TTF) was notably improved in the hepatectomy group compared with that in the RFA group, and this difference was statistically significant (median TTF, 71.1 vs. 38.0 months; P=0.041). However, the overall survival (OS) times of patients who received RFA and those who had hepatectomy did not differ significantly (median OS, not reached vs. not reached, P=0.120). There was no statistically significant distinction in PFS and TTF between patients who underwent hepatectomy combined with postoperative TKI and those who underwent hepatectomy combined with perioperative TKI (median PFS, 29.5 vs. not reached; P=0.520; median TTF, 66.4 months vs. 71.1 months; P=0.430). The univariate and multivariate analyses consistently identified the sole prognostic factor affecting PFS as hepatectomy combined with TKI therapy (hazard ratio, 0.379; 95% CI, 0.159‑0.899; P=0.028). In conclusion, hepatectomy combined with TKI therapy improved prognosis for patients with liver metastases to a greater extent than RFA combined with TKI therapy. For this type of patient, hepatectomy may be a preferable option.
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Copy and paste a formatted citation
Spandidos Publications style
Zeng Y, Ling Y, Chen X, Ding C, Jin Y, Feng S, Chen Z, Guo J and Qiu H: Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors. Oncol Lett 27: 133, 2024.
APA
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S. ... Qiu, H. (2024). Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors. Oncology Letters, 27, 133. https://doi.org/10.3892/ol.2024.14266
MLA
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S., Chen, Z., Guo, J., Qiu, H."Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors". Oncology Letters 27.3 (2024): 133.
Chicago
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S., Chen, Z., Guo, J., Qiu, H."Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors". Oncology Letters 27, no. 3 (2024): 133. https://doi.org/10.3892/ol.2024.14266
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng Y, Ling Y, Chen X, Ding C, Jin Y, Feng S, Chen Z, Guo J and Qiu H: Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors. Oncol Lett 27: 133, 2024.
APA
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S. ... Qiu, H. (2024). Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors. Oncology Letters, 27, 133. https://doi.org/10.3892/ol.2024.14266
MLA
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S., Chen, Z., Guo, J., Qiu, H."Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors". Oncology Letters 27.3 (2024): 133.
Chicago
Zeng, Y., Ling, Y., Chen, X., Ding, C., Jin, Y., Feng, S., Chen, Z., Guo, J., Qiu, H."Radiofrequency ablation vs. hepatectomy for liver metastases from gastrointestinal stromal tumors". Oncology Letters 27, no. 3 (2024): 133. https://doi.org/10.3892/ol.2024.14266
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