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Review Open Access

Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)

  • Authors:
    • Jie Zhou
    • Ping Zhou
    • Jinfang Wang
    • Jie Song
  • View Affiliations / Copyright

    Affiliations: College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China, College of Chinese Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China, College of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 137
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    Published online on: February 1, 2024
       https://doi.org/10.3892/ol.2024.14270
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Abstract

Angiogenesis plays a crucial role in tumor growth and metastasis, and is heavily influenced by the tumor microenvironment (TME). Endothelial cell dysfunction is a key factor in tumor angiogenesis and is characterized by the aberrant expression of pro‑angiogenic factors. Endothelial cell specific molecule‑1 (ESM1), also known as endocan, is a marker of endothelial cell dysfunction. Although ESM1 is primarily expressed in normal endothelial cells, dysregulated ESM1 expression has been observed in human tumors and animal tumor models, and implicated in tumor growth, metastasis and angiogenesis. The precise role of ESM1 in tumor angiogenesis and its potential regulatory mechanisms are not yet conclusively defined. However, the aim of the present review was to explore the involvement of ESM1 in the process of tumor angiogenesis in the TME and the characteristics of neovascularization. In addition, the present review discusses the interaction between ESM1 and angiogenic factors, as well as the mechanisms through which ESM1 contributes to tumor angiogenesis. Furthermore, the reciprocal regulation between ESM1 and the TME is explored. Finally, the potential of targeting ESM1 as a therapeutic strategy for tumor angiogenesis is presented.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou J, Zhou P, Wang J and Song J: Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review). Oncol Lett 27: 137, 2024.
APA
Zhou, J., Zhou, P., Wang, J., & Song, J. (2024). Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review). Oncology Letters, 27, 137. https://doi.org/10.3892/ol.2024.14270
MLA
Zhou, J., Zhou, P., Wang, J., Song, J."Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)". Oncology Letters 27.3 (2024): 137.
Chicago
Zhou, J., Zhou, P., Wang, J., Song, J."Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)". Oncology Letters 27, no. 3 (2024): 137. https://doi.org/10.3892/ol.2024.14270
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou J, Zhou P, Wang J and Song J: Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review). Oncol Lett 27: 137, 2024.
APA
Zhou, J., Zhou, P., Wang, J., & Song, J. (2024). Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review). Oncology Letters, 27, 137. https://doi.org/10.3892/ol.2024.14270
MLA
Zhou, J., Zhou, P., Wang, J., Song, J."Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)". Oncology Letters 27.3 (2024): 137.
Chicago
Zhou, J., Zhou, P., Wang, J., Song, J."Roles of endothelial cell specific molecule‑1 in tumor angiogenesis (Review)". Oncology Letters 27, no. 3 (2024): 137. https://doi.org/10.3892/ol.2024.14270
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