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Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist

  • Authors:
    • Tatsuhiko Kohno
    • Jun Kinoshita
    • Katsunobu Oyama
    • Hiroto Saito
    • Mari Shimada
    • Toshikatsu Tsuji
    • Daisuke Yamamoto
    • Hideki Moriyama
    • Noriyuki Inaki
    • Tetsuo Ohta
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Kanazawa University, Kanazawa, Ishikawa 920‑8641, Japan, Department of Surgery, Public Central Hospital of Matto Ishikawa, Hakusan, Ishikawa 924‑0865, Japan
    Copyright: © Kohno et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 147
    |
    Published online on: February 8, 2024
       https://doi.org/10.3892/ol.2024.14280
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Abstract

Reflux of gastroduodenal contents into the esophagus leads to the development of esophagitis and inflammation‑associated pathologies, such as Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). The role of the lipoxygenase (LOX) pathway in carcinogenesis has been recently reported; however, its involvement in esophageal carcinogenesis remains unclear. To address this, the present study investigated the potential of pranlukast, a cysteinyl leukotriene receptor‑1 antagonist, to suppress the progression of BE and EAC in a rat duodenogastroesophageal reflux (DGER) model. Male Wistar rats that underwent DGER were divided into two groups. One group was fed commercial chow (control group), and the other was fed experimental chow containing pranlukast (pranlukast group). The rats were sacrificed at 10, 20, 30 and 40 weeks after surgery, and their esophagi were examined. Expression levels of 5‑LOX, CD68, IL‑8, VEGF and Ki‑67 were investigated using immunohistochemistry, and apoptosis was analyzed using the TUNEL method. In the pranlukast group, esophagitis was milder, and the incidence of BE and EAC was significantly lower (P<0.05) compared with that in the control group at 40 weeks after surgery. The number of cells positive for IL‑8 and VEGF were significantly lower in the pranlukast group compared with the control group. Proliferative activity was also lower in the pranlukast group compared with the control group (P<0.05). Pranlukast treatment increased apoptosis (P<0.05). Overall, Pranlukast suppressed esophageal carcinogenesis in a rat DGER model, decreasing inflammatory cytokines such as IL‑8 and VEGF.
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Copy and paste a formatted citation
Spandidos Publications style
Kohno T, Kinoshita J, Oyama K, Saito H, Shimada M, Tsuji T, Yamamoto D, Moriyama H, Inaki N, Ohta T, Ohta T, et al: Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist. Oncol Lett 27: 147, 2024.
APA
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T. ... Ohta, T. (2024). Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist. Oncology Letters, 27, 147. https://doi.org/10.3892/ol.2024.14280
MLA
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T., Yamamoto, D., Moriyama, H., Inaki, N., Ohta, T."Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist". Oncology Letters 27.4 (2024): 147.
Chicago
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T., Yamamoto, D., Moriyama, H., Inaki, N., Ohta, T."Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist". Oncology Letters 27, no. 4 (2024): 147. https://doi.org/10.3892/ol.2024.14280
Copy and paste a formatted citation
x
Spandidos Publications style
Kohno T, Kinoshita J, Oyama K, Saito H, Shimada M, Tsuji T, Yamamoto D, Moriyama H, Inaki N, Ohta T, Ohta T, et al: Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist. Oncol Lett 27: 147, 2024.
APA
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T. ... Ohta, T. (2024). Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist. Oncology Letters, 27, 147. https://doi.org/10.3892/ol.2024.14280
MLA
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T., Yamamoto, D., Moriyama, H., Inaki, N., Ohta, T."Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist". Oncology Letters 27.4 (2024): 147.
Chicago
Kohno, T., Kinoshita, J., Oyama, K., Saito, H., Shimada, M., Tsuji, T., Yamamoto, D., Moriyama, H., Inaki, N., Ohta, T."Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist". Oncology Letters 27, no. 4 (2024): 147. https://doi.org/10.3892/ol.2024.14280
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