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Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy

  • Authors:
    • Dan Zhang
    • Jingjing Jin
    • Jianying Dou
    • Yan Huang
    • Haibo Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China, Keenan Research Centre for Biomedical Science of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, ON M5B1T8, Canada
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 154
    |
    Published online on: February 14, 2024
       https://doi.org/10.3892/ol.2024.14287
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Abstract

Lung cancer is a prevalent and highly lethal disease often complicated by lower respiratory tract infections. Microbial patterns in these infections vary based on treatment modalities. The present study explored the impact of lung cancer treatments on pathogens and clinical characteristics in the presence of lower respiratory tract infections to inform antimicrobial drug selection. A retrospective analysis was performed that included data from 93 patients diagnosed with advanced lung cancer and lower respiratory tract infections between January 2019 and December 2021. Patients were divided into the targeted therapy and chemoradiotherapy groups. Clinical, nutritional, biochemical, infection and pathogenetic indicators were compared. Of the 93 cases, 24 were in the targeted therapy group and 69 were in the chemoradiotherapy group. Pathological type and hospitalization duration differed significantly (P<0.05), but age, sex, smoking history, alcohol consumption and underlying diseases did not (P>0.05). Lymphocyte counts differed (P<0.05), while body mass index, albumin, hemoglobin, alanine aminotransferase and creatinine levels, erythrocyte sedimentation rate, hypersensitive C‑reactive protein and procalcitonin levels, and the percentage of neutrophils did not (P>0.05). Pathogenetic testing was negative in 15 patients and positive in 78 patients, with Gram‑negative bacteria (61.77%), fungi (17.65%) and viruses (11.76%) predominant in the targeted therapy group. In the chemoradiotherapy group, Gram‑negative bacteria (47.46%), fungi (28.81%) and viruses (16.95%) were also more prevalent. Candida albicans was the most frequent fungal infection in both groups, and mixed infections were common (50% in targeted therapy and 73.92% in chemoradiotherapy). The chemoradiotherapy group had significantly more mixed infections (P<0.05). Overall, common pathogens in both groups included Gram‑negative bacteria, fungi and viruses. Chemoradiotherapy patients experienced longer hospital stays and a higher incidence of mixed infections, predominantly involving Gram‑negative bacteria and fungi. The results provide valuable insights into the rational selection of empirical antibiotics and antifungals for critically ill patients with lung cancer and lower respiratory tract infections in targeted therapy or chemoradiotherapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang D, Jin J, Dou J, Huang Y and Zhang H: Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy. Oncol Lett 27: 154, 2024.
APA
Zhang, D., Jin, J., Dou, J., Huang, Y., & Zhang, H. (2024). Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy. Oncology Letters, 27, 154. https://doi.org/10.3892/ol.2024.14287
MLA
Zhang, D., Jin, J., Dou, J., Huang, Y., Zhang, H."Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy". Oncology Letters 27.4 (2024): 154.
Chicago
Zhang, D., Jin, J., Dou, J., Huang, Y., Zhang, H."Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy". Oncology Letters 27, no. 4 (2024): 154. https://doi.org/10.3892/ol.2024.14287
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang D, Jin J, Dou J, Huang Y and Zhang H: Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy. Oncol Lett 27: 154, 2024.
APA
Zhang, D., Jin, J., Dou, J., Huang, Y., & Zhang, H. (2024). Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy. Oncology Letters, 27, 154. https://doi.org/10.3892/ol.2024.14287
MLA
Zhang, D., Jin, J., Dou, J., Huang, Y., Zhang, H."Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy". Oncology Letters 27.4 (2024): 154.
Chicago
Zhang, D., Jin, J., Dou, J., Huang, Y., Zhang, H."Impact on hospitalization and infection patterns of advanced lung cancer with lower respiratory tract infections: Targeted therapy vs. chemoradiotherapy". Oncology Letters 27, no. 4 (2024): 154. https://doi.org/10.3892/ol.2024.14287
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