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Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review

  • Authors:
    • Linhao Ran
    • Ying Liu
    • Li Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, People's Hospital of Chongqing Banan District, Chongqing 401320, P.R. China, Department of Ultrasound, People's Hospital of Chongqing Banan District, Chongqing 401320, P.R. China
    Copyright: © Ran et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 156
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    Published online on: February 15, 2024
       https://doi.org/10.3892/ol.2024.14289
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Abstract

Testicular seminoma is a relatively rare malignant tumor, with the most common site of recurrence and metastasis being the retroperitoneal lymph nodes. Since seminoma is highly sensitive to radiotherapy and chemotherapy, even if it metastasizes, its cure rate is still >95%. However, the long‑term toxicity and side effects of radiotherapy and chemotherapy cannot be ignored. Iodine‑125 seeds represent a low‑energy radioactive source that kills tumor cells while protecting the surrounding normal tissues, and brachytherapy using iodine‑125 seeds has been widely used for the treatment of various malignancies. In addition, carboplatin can be used as an alternative to cisplatin‑based combination chemotherapy to reduce the incidence of pulmonary toxicity, neurological damage and renal toxicity. In the present study, a case in which iodine‑125 seeds were implanted for the treatment of retroperitoneal metastatic seminoma is reported. The patient was diagnosed with postoperative recurrence of seminoma that metastasized to the retroperitoneal lymph nodes. Since the tumor was large and surrounded blood vessels, surgical intervention and external radiotherapy were not considered. Moreover, considering the potential long‑term toxic side effects of standard chemotherapy, a treatment plan for the patient using iodine‑125 seed implantation combined with carboplatin (AUC7) therapy was finally formulated. No disease recurrence or toxic reactions occurred during the 3‑year follow‑up after treatment. The present case therefore demonstrated the antitumor efficacy and reduced toxicity of iodine‑125 seeds combined with carboplatin for treating seminoma.
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Copy and paste a formatted citation
Spandidos Publications style
Ran L, Liu Y and Jiang L: Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review. Oncol Lett 27: 156, 2024.
APA
Ran, L., Liu, Y., & Jiang, L. (2024). Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review. Oncology Letters, 27, 156. https://doi.org/10.3892/ol.2024.14289
MLA
Ran, L., Liu, Y., Jiang, L."Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review". Oncology Letters 27.4 (2024): 156.
Chicago
Ran, L., Liu, Y., Jiang, L."Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review". Oncology Letters 27, no. 4 (2024): 156. https://doi.org/10.3892/ol.2024.14289
Copy and paste a formatted citation
x
Spandidos Publications style
Ran L, Liu Y and Jiang L: Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review. Oncol Lett 27: 156, 2024.
APA
Ran, L., Liu, Y., & Jiang, L. (2024). Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review. Oncology Letters, 27, 156. https://doi.org/10.3892/ol.2024.14289
MLA
Ran, L., Liu, Y., Jiang, L."Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review". Oncology Letters 27.4 (2024): 156.
Chicago
Ran, L., Liu, Y., Jiang, L."Iodine‑125 seeds combined with carboplatin in the treatment of retroperitoneal metastatic seminoma: A case report and literature review". Oncology Letters 27, no. 4 (2024): 156. https://doi.org/10.3892/ol.2024.14289
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