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Article Open Access

Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis

  • Authors:
    • Meikai Zhu
    • Zhifeng Liu
    • Yongheng Zhou
    • Zhiwen Jiang
    • Shouzhen Chen
    • Wenfu Wang
    • Benkang Shi
    • Yaofeng Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Urology, Tai'an City Central Hospital, Tai'an, Shandong 271000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 162
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    Published online on: February 19, 2024
       https://doi.org/10.3892/ol.2024.14295
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Abstract

To evaluate the effects of neoadjuvant vascular endothelial growth factor‑tyrosine kinase inhibitor (VEGF‑TKI) treatment on surgery in patients with renal cell carcinoma (RCC), sources from Embase, PubMed and the Cochrane Library databases collected from inception to December, 2022 were used for analysis in the present study, according to the Preferred Reporting Items for Systematic Reviews and Meta‑Analyses guidelines. Data regarding surgical outcomes were collected. The pooled effect sizes were calculated in terms of the risk ratio (RR)/standard mean difference (SMD) with 95% confidence intervals (CIs) using the random‑effects model. Subgroup and sensitivity analyses were used to explore the source of heterogeneity within the data. In total, 9 identified articles involving 829 patients (336 in the neoadjuvant + surgery group; 493 in the surgery group) were included in the present study, according to the criteria. The results demonstrated that there were no significant differences in blood loss (SMD=‑0.11; 95% CI, ‑0.63‑0.41; P=0.68), postoperative length of hospital stay or total length of hospital stay (SMD=0.23; 95% CI, ‑0.55‑1.01; P=0.57) or complications (RR=1.16; 95% CI, 0.80‑1.67; P=0.44) between the two groups. However, neoadjuvant therapy reduced the operation time (SMD=‑0.67; 95% CI, ‑1.25‑ ‑0.09; P=0.02) and resulted in a greater proportion of patients choosing partial nephrectomy (RR=1.84; 95% CI, 1.47‑2.31; P<0.00001). In the subgroup analysis, the blood loss was significantly lower in patients with RCC with inferior vena cava tumor thrombus in the neoadjuvant group (SMD=‑1.10; 95% CI, ‑1.82‑ ‑0.38; P=0.003). In conclusion, the results of the present study indicated that neoadjuvant VEGF‑TKI treatment in patients with RCC shortened operation time, decreased blood loss and did not cause an increase in perioperative complications. In addition, this treatment modality may encourage patients to opt for partial nephrectomy to preserve renal function.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu M, Liu Z, Zhou Y, Jiang Z, Chen S, Wang W, Shi B and Zhu Y: Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis. Oncol Lett 27: 162, 2024.
APA
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W. ... Zhu, Y. (2024). Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis. Oncology Letters, 27, 162. https://doi.org/10.3892/ol.2024.14295
MLA
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W., Shi, B., Zhu, Y."Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 27.4 (2024): 162.
Chicago
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W., Shi, B., Zhu, Y."Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 27, no. 4 (2024): 162. https://doi.org/10.3892/ol.2024.14295
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu M, Liu Z, Zhou Y, Jiang Z, Chen S, Wang W, Shi B and Zhu Y: Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis. Oncol Lett 27: 162, 2024.
APA
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W. ... Zhu, Y. (2024). Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis. Oncology Letters, 27, 162. https://doi.org/10.3892/ol.2024.14295
MLA
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W., Shi, B., Zhu, Y."Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 27.4 (2024): 162.
Chicago
Zhu, M., Liu, Z., Zhou, Y., Jiang, Z., Chen, S., Wang, W., Shi, B., Zhu, Y."Effects of neoadjuvant VEGF‑TKI treatment on surgery for renal cell carcinoma: A systematic review and meta‑analysis". Oncology Letters 27, no. 4 (2024): 162. https://doi.org/10.3892/ol.2024.14295
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