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Case Report Open Access

Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report

  • Authors:
    • Sayoko Sumiyoshi
    • Terumi Takahara
    • Kazuto Shibuya
    • Johji Imura
    • Akira Noguchi
    • Kazuto Tajiri
    • Masami Minemura
    • Tsutomu Fujii
    • Kenichi Hirabayashi
  • View Affiliations / Copyright

    Affiliations: Department of Diagnostic Pathology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930‑0194, Japan, Third Department of Medicine, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930‑0194, Japan, Department of Surgery and Sciences, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama 930‑0194, Japan, Department of Diagnostic Pathology, Kumagaya General Hospital, Kumagaya, Saitama 360‑8567, Japan
    Copyright: © Sumiyoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 168
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    Published online on: February 22, 2024
       https://doi.org/10.3892/ol.2024.14301
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Abstract

The development of tumors in livers transplanted from hepatitis B virus (HBV)‑negative donors to patients with hepatitis B and cirrhosis is rare. The present study describes the case of a woman in her 60s who developed hepatocellular carcinoma (HCC) in her grafted liver, 19 years after transplantation, as well as a metachronous colorectal tumor. The pathological findings, including clinical, immunohistochemical and molecular results, are described in the present case report. The liver tumor was a conventional HCC and the colorectal tumor comprised a tubular adenocarcinoma. Immunohistochemistry of both tumors showed a loss of expression of mutL homolog 1 and postmeiotic segregation increased 2 in the tumor cells, confirming microsatellite instability‑high (MSI‑H) status. Furthermore, a molecular study detected the presence of genes located on the Y chromosome in the normal and tumor tissues of the liver, proving that the HCC occurred in the grafted liver. The present report also discusses that prolonged use of immunosuppressive drugs to prevent post‑transplant rejection, poorly controlled diabetes mellitus and MSI‑H may have contributed to the risk of tumor development.
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Copy and paste a formatted citation
Spandidos Publications style
Sumiyoshi S, Takahara T, Shibuya K, Imura J, Noguchi A, Tajiri K, Minemura M, Fujii T and Hirabayashi K: Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report. Oncol Lett 27: 168, 2024.
APA
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K. ... Hirabayashi, K. (2024). Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report. Oncology Letters, 27, 168. https://doi.org/10.3892/ol.2024.14301
MLA
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K., Minemura, M., Fujii, T., Hirabayashi, K."Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report". Oncology Letters 27.4 (2024): 168.
Chicago
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K., Minemura, M., Fujii, T., Hirabayashi, K."Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report". Oncology Letters 27, no. 4 (2024): 168. https://doi.org/10.3892/ol.2024.14301
Copy and paste a formatted citation
x
Spandidos Publications style
Sumiyoshi S, Takahara T, Shibuya K, Imura J, Noguchi A, Tajiri K, Minemura M, Fujii T and Hirabayashi K: Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report. Oncol Lett 27: 168, 2024.
APA
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K. ... Hirabayashi, K. (2024). Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report. Oncology Letters, 27, 168. https://doi.org/10.3892/ol.2024.14301
MLA
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K., Minemura, M., Fujii, T., Hirabayashi, K."Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report". Oncology Letters 27.4 (2024): 168.
Chicago
Sumiyoshi, S., Takahara, T., Shibuya, K., Imura, J., Noguchi, A., Tajiri, K., Minemura, M., Fujii, T., Hirabayashi, K."Hepatocellular carcinoma in a transplanted donor liver and colon cancer developing in a patient with a complex background: A case report". Oncology Letters 27, no. 4 (2024): 168. https://doi.org/10.3892/ol.2024.14301
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