Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2024 Volume 27 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study

  • Authors:
    • Toshiya Higashi
    • Katsutoshi Murase
    • Daichi Watanabe
    • Takuma Ishihara
    • Ryoma Yokoi
    • Masashi Kuno
    • Masahiro Fukada
    • Takuji Iwashita
    • Jesse Yu Tajima
    • Shigeru Kiyama
    • Yoshihiro Tanaka
    • Naoki Okumura
    • Masahito Shimizu
    • Nobuhisa Matsuhashi
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Gifu University Hospital, Gifu 501‑1194 Japan, Department of Pharmacy, Gifu University Hospital, Gifu 501‑1194 Japan, Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu 501‑1194 Japan, First Department of Internal Medicine, Gifu University Hospital, Gifu 501‑1194 Japan
    Copyright: © Higashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 171
    |
    Published online on: February 22, 2024
       https://doi.org/10.3892/ol.2024.14304
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recently, conversion surgery (CS) has been reported to improve the prognosis in patients with unresectable pancreatic ductal adenocarcinoma (UR‑PDAC) with a favorable response to intense chemotherapy or chemoradiotherapy. However, few pretherapeutic parameters predict the attainability of CS in patients with UR‑PDAC. The present study aimed to explore the pretherapeutic predictors for the attainability of CS in patients with UR‑PDAC. The present study retrospectively evaluated 130 patients with UR‑PDAC treated at Gifu University Hospital (Gifu, Japan) from January 2015 to December 2021. Survival analysis was performed using the Simon and Makuch‑modified Kaplan‑Meier method. The hazard ratio (HR) was estimated using a time‑varying Cox regression model. The association between each predictor and CS was evaluated using the univariate analysis and age‑adjusted Fine‑Gray sub‑distribution hazard model. The bootstrap bias‑corrected area under the receiver operating characteristic curve analysis for predicting CS was used to assess the cut‑off values for each predictor. The cumulative incidence rate was calculated with CS as the outcome when divided into two groups based on the cut‑off value of each pretherapeutic predictor. Among the 130 patients included in the analysis, only 14 (11%) underwent CS. The median survival time was significantly longer in patients who underwent CS compared with patients without CS (56.3 vs. 14.1 months; P<0.001). The age‑adjusted Fine‑Gray sub‑distribution hazard regression showed that the total protein (TP) [HR 2.81, 95% confidence interval (CI) 1.19‑6.65; P=0.018], neutrophil‑to‑lymphocyte ratio (NLR) (HR 0.53, 95% CI 0.31‑0.90; P=0.020), and lymphocyte‑to‑monocyte ratio (LMR) (HR 1.28, 95% CI 1.07‑1.53; P=0.006) were significantly associated with CS. Moreover, TP ≥6.8, NLR <2.84 and LMR ≥3.87 were associated with a higher cumulative incidence of CS. In conclusion, pretherapeutic TP, NLR and LMR are clinically feasible biomarkers for predicting the attainability of CS in patients with UR‑PDAC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Vincent A, Herman J, Schulick R, Hruban RH and Goggins M: Pancreatic cancer. Lancet. 378:607–620. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Conroy T, Desseigne F, Ychou M, Bouche O, Guimbaud R, Bécouarn Y, Adenis A, Raoul JL, Gourgou-Bourgade S, de la Fouchardière C, et al: FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 364:1817–1825. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, et al: Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 369:1691–1703. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Satoi S, Yamaue H, Kato K, Takahashi S, Hirono S, Takeda S, Eguchi H, Sho M, Wada K, Shinchi H, et al: Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: Results of a project study for pancreatic surgery by the Japanese society of hepato-biliary-pancreatic surgery. J Hepatobiliary Pancreat Sci. 20:590–600. 2013. View Article : Google Scholar : PubMed/NCBI

6 

National Comprehensive Cancer Network, . NCCN Clinical practice guidelines in oncology: pancreatic adenocarcinoma. https://www.nccn.org/professionals/physician_gls/pdf/pancreatic.pdfAugust 29–2023

7 

Zhou Y, Liao S, You J and Wu H: Conversion surgery for initially unresectable pancreatic ductal adenocarcinoma following induction therapy: A systematic review of the published literature. Updates Surg. 74:43–53. 2022. View Article : Google Scholar : PubMed/NCBI

8 

Tanaka M, Heckler M, Mihaljevic AL, Sun H, Klaiber U, Heger U, Buchler MW and Hackert T: CT response of primary tumor and CA19-9 predict resectability of metastasized pancreatic cancer after FOLFIRINOX. Eur J Surg Oncol. 45:1453–1459. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Wang M, Zhu P, Chen Z and Yang L: Conversion therapy, palliative chemotherapy and surgery, which of these is the best treatment for locally advanced and advanced pancreatic cancer? Anticancer Drugs. 33:e686–e691. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Yanagimoto H, Satoi S, Yamamoto T, Yamaki S, Hirooka S, Kotsuka M, Ryota H, Ishida M, Matsui Y and Sekimoto M: Benefits of conversion surgery after multimodal treatment for unresectable pancreatic ductal adenocarcinoma. Cancers (Basel). 12:14282020. View Article : Google Scholar : PubMed/NCBI

11 

Ushida Y, Inoue Y, Oba A, Mie T, Ito H, Ono Y, Sato T, Ozak a, Sasaki T, Saiura A, et al: Optimizing indications for conversion surgery based on analysis of 454 consecutive Japanese cases with unresectable pancreatic cancer who received modified FOLFIRINOX or gemcitabine plus nab-paclitaxel: A single-center retrospective study. Ann Surg Oncol. 29:5038–5050. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Takano N, Yamada S, Sonohara F, Inokawa Y, Takami H, Hayashi M, Koike M, Fujii T and Kodera Y: The impact of early tumor shrinkage on conversion surgery and the survival in patients with unresectable locally advanced pancreatic cancer. Surg Today. 51:1099–1107. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Lee M, Kang JS, Kim H, Kwon W, Lee SH, Ryu JK, Kim YT, Oh DY, Chie EK and Jang JY: Impact of conversion surgery on survival in locally advanced pancreatic cancer patients treated with FOLFIRINOX chemotherapy. J Hepatobiliary Pancreat Sci. 30:111–121. 2023. View Article : Google Scholar : PubMed/NCBI

14 

Mataki Y, Kurahara H, Idichi T, Tanoue K, Hozaka Y, Kawasaki Y, Iino S, Maemura K, Shinchi H and Ohtsuka T: Clinical benefits of conversion surgery for unresectable pancreatic ductal adenocarcinoma: A single-institution, retrospective analysis. Cancers (Basel). 13:10572021. View Article : Google Scholar : PubMed/NCBI

15 

Kokumai T, Aoki S, Mizuma M, Maeda S, Ohtsuka H, Nakagawa K, Morikawa T, Motoi F, Kamei T and Unno M: Prognostic value of an inflammation-based nutritional score for patients with initially unresectable pancreatic adenocarcinoma undergoing conversion surgery following chemo-/radiotherapy. Surg Today. 51:1682–1693. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Tsuchiya N, Matsuyama R, Murakami T, Yabushita Y, Sawada Y, Kumamoto T and Endo I: Role of conversion surgery for unresectable pancreatic cancer after long-term chemotherapy. World J Surg. 44:2752–2760. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Japan Pancreas Society, . Classification of Pancreatic Carcinoma (4th English Edition). Kanehara & Co.; Tokyo, Japan: 2017, http://www.suizou.org/pdf/Classification_of_Pancreatic_Carcinoma_4th_Engl_ed.pdfAugust 30–2023

18 

Kanda M, Fujii T, Kodera Y, Nagai S, Takeda S and Nakao A: Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg. 98:268–274. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Toiyama Y, Miki C, Inoue Y, Tanaka K, Mohri Y and Kusunoki M: Evaluation of an inflammation-based prognostic score for the identification of patients requiring postoperative adjuvant chemotherapy for stage II colorectal cancer. Exp Ther Med. 2:95–101. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Simon R and Makuch RW: A non-parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non-responder bias. Stat Med. 3:35–44. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Schultz LR, Peterson EL and Breslau N: Graphing survival curve estimates for time-dependent covariates. Int J Methods Psychiatr Res. 11:68–74. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Cao J, Luo F, Zeng K, Ma W, Lu F, Huang Y, Zhang L and Zhao H: Predictive value of high preoperative serum total protein and elevated hematocrit in patients with non-small-cell lung cancer after radical resection. Nutr Cancer. 74:3533–3545. 2022. View Article : Google Scholar : PubMed/NCBI

24 

Yao Y, Wang Z, Yong L, Yao Q, Tian X, Wang T, Yang Q, Hao C and Zhou T: Longitudinal and time-to-event modeling for prognostic implications of radical surgery in retroperitoneal sarcoma. CPT Pharmacometrics Syst Pharmacol. 11:1170–1182. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Abbasi B, Hayat A, Lyons M, Gupta A and Gupta S: Serum protein and electrolyte imbalances are associated with chemotherapy induced neutropenia. Heliyon. 8:e099492022. View Article : Google Scholar : PubMed/NCBI

26 

Iwai N, Okuda T, Sakagami J, Harada T, Ohara T, Taniguchi M, Sakai H, Oka K, Hara T, Tsuji T, et al: Neutrophil to lymphocyte ratio predicts prognosis in unresectable pancreatic cancer. Sci Rep. 10:187582020. View Article : Google Scholar : PubMed/NCBI

27 

Allen J, Cernik C, Bajwa S, Al-Rajabi R, Saeed A, Baranda J, Williamson S, Sun W and Kasi A: Association of neutrophil, platelet, and lymphocyte ratios with the prognosis in unresectable and metastatic pancreatic cancer. J Clin Med. 9:32832020. View Article : Google Scholar : PubMed/NCBI

28 

Terao T, Kumagi T, Hyodo I, Yokota T, Azemoto N, Miyata H, Kuroda T, Ohno Y, Tanaka Y, Shibata N, et al: Simple prognostic markers for optimal treatment of patients with unresectable pancreatic cancer. Medicine (Baltimore). 100:e275912021. View Article : Google Scholar : PubMed/NCBI

29 

Shimizu T, Taniguchi K, Asakuma M, Tomioka A, Inoue Y, Komeda K, Hirokawa F and Uchiyama K: Lymphocyte-to-monocyte ratio and prognostic nutritional index predict poor prognosis in patients on chemotherapy for unresectable pancreatic cancer. Anticancer Res. 39:2169–2176. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Kaya T, Acikgoz SB, Yildirim M, Nalbant A, Altas AE and Cinemre H: Association between neutrophil-to-lymphocyte ratio and nutritional status in geriatric patients. J Clin Lab Anal. 33:e226362019. View Article : Google Scholar : PubMed/NCBI

31 

Nakamura Y, Imada A, Fukugaki A, Kanto S, Yamaura T, Kinjo Y and Kuroda N: Association of nutritional risk and systemic inflammation with survival in patients with colorectal cancer who underwent curative surgery. Clin Nutr ESPEN. 49:417–424. 2022. View Article : Google Scholar : PubMed/NCBI

32 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Santarpia L, Contaldo F and Pasanisi F: Nutritional screening and early treatment of malnutrition in cancer patients. J Cachexia Sarcopenia Muscle. 2:27–35. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Murry DJ, Riva L and Poplack DG: Impact of nutrition on pharmacokinetics of anti-neoplastic agents. Int J Cancer. (Suppl 11):48–51. 1998. View Article : Google Scholar : PubMed/NCBI

35 

Ikuta S, Sonoda T, Aihara T, Nakajima T and Yamanaka N: The preoperative modified Glasgow prognostic score for the prediction of survival after pancreatic cancer resection following non-surgical treatment of an initially unresectable disease. Contemp Oncol (Pozn). 22:229–235. 2018.PubMed/NCBI

36 

Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C and Flavell RA: Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 13:759–771. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Higashi T, Murase K, Watanabe D, Ishihara T, Yokoi R, Kuno M, Fukada M, Iwashita T, Tajima JY, Kiyama S, Kiyama S, et al: Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study. Oncol Lett 27: 171, 2024.
APA
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M. ... Matsuhashi, N. (2024). Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study. Oncology Letters, 27, 171. https://doi.org/10.3892/ol.2024.14304
MLA
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M., Fukada, M., Iwashita, T., Tajima, J. Y., Kiyama, S., Tanaka, Y., Okumura, N., Shimizu, M., Matsuhashi, N."Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study". Oncology Letters 27.4 (2024): 171.
Chicago
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M., Fukada, M., Iwashita, T., Tajima, J. Y., Kiyama, S., Tanaka, Y., Okumura, N., Shimizu, M., Matsuhashi, N."Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study". Oncology Letters 27, no. 4 (2024): 171. https://doi.org/10.3892/ol.2024.14304
Copy and paste a formatted citation
x
Spandidos Publications style
Higashi T, Murase K, Watanabe D, Ishihara T, Yokoi R, Kuno M, Fukada M, Iwashita T, Tajima JY, Kiyama S, Kiyama S, et al: Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study. Oncol Lett 27: 171, 2024.
APA
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M. ... Matsuhashi, N. (2024). Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study. Oncology Letters, 27, 171. https://doi.org/10.3892/ol.2024.14304
MLA
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M., Fukada, M., Iwashita, T., Tajima, J. Y., Kiyama, S., Tanaka, Y., Okumura, N., Shimizu, M., Matsuhashi, N."Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study". Oncology Letters 27.4 (2024): 171.
Chicago
Higashi, T., Murase, K., Watanabe, D., Ishihara, T., Yokoi, R., Kuno, M., Fukada, M., Iwashita, T., Tajima, J. Y., Kiyama, S., Tanaka, Y., Okumura, N., Shimizu, M., Matsuhashi, N."Pretherapeutic factors predicting conversion surgery in unresectable pancreatic ductal adenocarcinoma: A retrospective study". Oncology Letters 27, no. 4 (2024): 171. https://doi.org/10.3892/ol.2024.14304
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team