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Review Open Access

The landscape of 8q24 cytoband in gastric cancer (Review)

  • Authors:
    • Violeta Larios-Serrato
    • Hilda-Alicia Valdez-Salazar
    • Martha-Eugenia Ruiz-Tachiquín
  • View Affiliations / Copyright

    Affiliations: Genomics Biotechnology and Bioinformatics Laboratory, National School of Biological Sciences (ENCB), National Polytechnic Institute (IPN), Lázaro Cárdenas Professional Unit, Mexico City 11340, Mexico, Medical Research Unit in Infectious and Parasitic Diseases (UIMEIP), Pediatrics Hospital ʻDr. Silvestre Frenk Freund’, Mexico City 06720, Mexico, Medical Research Unit in Oncological Diseases (UIMEO), Oncology Hospital, Century XXI National Medical Center, Mexican Social Security Institute (IMSS), Mexico City 06720, Mexico
    Copyright: © Larios-Serrato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 179
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    Published online on: February 28, 2024
       https://doi.org/10.3892/ol.2024.14311
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Abstract

Worldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24 have been frequently described; essential genes are present in this cytoband, regulating the homeostasis of crucial biological processes, such as the MYC gene, which induces expression of selective genes to promote cell growth and proliferation. Conversely, DNA sequence variations can also occur when a single nucleotide in the genome sequence is altered, and this is termed a single nucleotide polymorphism (SNP). These alterations, which can serve as a biological marker, are present in at least 1% of the population and assist in identifying genes associated with GC. In the present review, 12 genes present in cytoband 8q24 related to GC (NSMCE2, PCAT1, CASC19, CASC8, CCAT2, PRNCR1, POU5F1B, PSCA, JRK, MYC, PVT1 and PTK2) are discussed. The PSCA gene was cited more frequently than others; it has four known SNPs associated with GC (rs2978980, rs2294008, rs2976392 and rs9297976). Thus, these SNPs should be further studied in different populations to determine their risk value in patients with GC.
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Copy and paste a formatted citation
Spandidos Publications style
Larios-Serrato V, Valdez-Salazar H and Ruiz-Tachiquín M: The landscape of 8q24 cytoband in gastric cancer (Review). Oncol Lett 27: 179, 2024.
APA
Larios-Serrato, V., Valdez-Salazar, H., & Ruiz-Tachiquín, M. (2024). The landscape of 8q24 cytoband in gastric cancer (Review). Oncology Letters, 27, 179. https://doi.org/10.3892/ol.2024.14311
MLA
Larios-Serrato, V., Valdez-Salazar, H., Ruiz-Tachiquín, M."The landscape of 8q24 cytoband in gastric cancer (Review)". Oncology Letters 27.4 (2024): 179.
Chicago
Larios-Serrato, V., Valdez-Salazar, H., Ruiz-Tachiquín, M."The landscape of 8q24 cytoband in gastric cancer (Review)". Oncology Letters 27, no. 4 (2024): 179. https://doi.org/10.3892/ol.2024.14311
Copy and paste a formatted citation
x
Spandidos Publications style
Larios-Serrato V, Valdez-Salazar H and Ruiz-Tachiquín M: The landscape of 8q24 cytoband in gastric cancer (Review). Oncol Lett 27: 179, 2024.
APA
Larios-Serrato, V., Valdez-Salazar, H., & Ruiz-Tachiquín, M. (2024). The landscape of 8q24 cytoband in gastric cancer (Review). Oncology Letters, 27, 179. https://doi.org/10.3892/ol.2024.14311
MLA
Larios-Serrato, V., Valdez-Salazar, H., Ruiz-Tachiquín, M."The landscape of 8q24 cytoband in gastric cancer (Review)". Oncology Letters 27.4 (2024): 179.
Chicago
Larios-Serrato, V., Valdez-Salazar, H., Ruiz-Tachiquín, M."The landscape of 8q24 cytoband in gastric cancer (Review)". Oncology Letters 27, no. 4 (2024): 179. https://doi.org/10.3892/ol.2024.14311
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