Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma

  • Authors:
    • Zhenyu Bi
    • Jinghao Zhou
    • Yan Ma
    • Qingxin Guo
    • Boyang Ju
    • Haoran Zou
    • Zuhao Zhan
    • Feihong Yang
    • Han Du
    • Xiuguo Gan
    • Erlin Song
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of Oncology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, P.R. China, Department of Urology, Hongqi Hospital Affiliated to Mudanjiang Medical College, Mudanjiang, Heilongjiang 157009, P.R. China, Department of Urology, Zhumadian Central Hospital, Zhumadian, Henan 463000, P.R. China, Department of Urology, The First Hospital of Zibo, Zibo, Shandong 255200, P.R. China, Department of Urology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541001, P.R. China
    Copyright: © Bi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 190
    |
    Published online on: March 1, 2024
       https://doi.org/10.3892/ol.2024.14323
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC‑related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super‑enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial‑mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sensitive to immunotherapy. In the present study, an Arraystar human SE‑long non‑coding RNA (lncRNA) microarray was first employed to profile the differentially expressed SE‑lncRNAs and mRNAs in 5 paired ccRCC and peritumoral tissues and to identify SE‑related genes. The overlap of these genes with immune genes was then determined to identify SE‑related immune genes. A model for predicting clinical prognosis and response to immunotherapy was built following the comprehensive analysis of a ccRCC gene expression dataset from The Cancer Genome Atlas (TCGA) database. The patients from TCGA were divided into high‑ and low‑risk groups based on the median score derived from the risk model, and the Kaplan‑Meier survival analysis showed that the low‑risk group had a higher survival probability. In addition, according to the receiver operating characteristic curve analysis, the risk model had more advantages than other clinical factors in predicting the overall survival (OS) rate of patients with ccRCC. Using this model, it was demonstrated that the high‑risk group had a more robust immune response. Furthermore, 61 potential drugs with half‑maximal inhibitory concentration values that differed significantly between the two patient groups were screened to investigate potential drug treatment of ccRCC. In summary, the present study provided a novel index for predicting the survival probability of patients with ccRCC and may provide some insights into the mechanisms through which SE‑related immune genes influence the diagnosis, prognosis and potential treatment drugs of ccRCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Ljungberg B, Albiges L, Abu-Ghanem Y, Bensalah K, Dabestani S, Fernández-Pello S, Giles RH, Hofmann F, Hora M, Kuczyk MA, et al: European association of urology guidelines on renal cell carcinoma: The 2019 update. Eur Urol. 75:799–810. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Finelli A, Ismaila N, Bro B, Durack J, Eggener S, Evans A, Gill I, Graham D, Huang W, Jewett MA, et al: Management of small renal masses: American society of clinical oncology clinical practice guideline. J Clin Oncol. 35:668–680. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Panne D: The enhanceosome. Curr Opin Struct Biol. 18:236–242. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Spitz F and Furlong EE: Transcription factors: From enhancer binding to developmental control. Nat Rev Genet. 13:613–626. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Calo E and Wysocka J: Modification of enhancer chromatin: What, how, and why. Mol Cell. 49:825–837. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Zhang C, Wei S, Sun WP, Teng K, Dai MM, Wang FW, Chen JW, Ling H, Ma XD, Feng ZH, et al: Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of hepatocellular carcinoma. Theranostics. 10:9066–9082. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Nguyen TTT, Zhang Y, Shang E, Shu C, Torrini C, Zhao J, Bianchetti E, Mela A, Humala N, Mahajan A, et al: HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models. J Clin Invest. 130:3699–3716. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, et al: A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nat Commun. 8:148022017. View Article : Google Scholar : PubMed/NCBI

9 

Shang E, Nguyen TTT, Shu C, Westhoff MA, Karpel-Massler G and Siegelin MD: Epigenetic targeting of Mcl-1 is synthetically lethal with Bcl-xL/Bcl-2 inhibition in model systems of glioblastoma. Cancers (Basel). 12:21372020. View Article : Google Scholar : PubMed/NCBI

10 

Şenbabaoğlu Y, Gejman RS, Winer AG, Liu M, Van Allen EM, de Velasco G, Miao D, Ostrovnaya I, Drill E, Luna A, et al: Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures. Genome Biol. 17:2312016. View Article : Google Scholar : PubMed/NCBI

11 

Escudier B: Emerging immunotherapies for renal cell carcinoma. Ann Oncol. 23 (Suppl 8):viii35–viii40. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Dunnick NR: Renal cell carcinoma: Staging and surveillance. Abdom Radiol (NY). 41:1079–1085. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Sun C, Mezzadra R and Schumacher TN: Regulation and function of the PD-L1 checkpoint. Immunity. 48:434–452. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Xu Y, Wu Y, Zhang S, Ma P, Jin X, Wang Z, Yao M, Zhang E, Tao B, Qin Y, et al: A tumor-specific super-enhancer drives immune evasion by guiding synchronous expression of PD-L1 and PD-L2. Cell Rep. 29:3435–3447.e4. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Ma P, Jin X, Fan Z, Wang Z, Yue S, Wu C, Chen S, Wu Y, Chen M, Gu D, et al: Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion via integrin/BRAF/TAK1/ERK/ETV4 signaling. Cancer Biol Med. 19:669–684. 2021. View Article : Google Scholar : PubMed/NCBI

16 

Oh S, Shin S and Janknecht R: ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim Biophys Acta. 1826:1–12. 2012.PubMed/NCBI

17 

Yu D, Yang X, Lin J, Cao Z, Lu C, Yang Z, Zheng M, Pan R and Cai W: Super-enhancer induced IL-20RA promotes proliferation/metastasis and immune evasion in colorectal cancer. Front Oncol. 11:7246552021. View Article : Google Scholar : PubMed/NCBI

18 

Li X, Li Y, Yu X and Jin F: Identification and validation of stemness-related lncRNA prognostic signature for breast cancer. J Transl Med. 18:3312020. View Article : Google Scholar : PubMed/NCBI

19 

Xu F, Huang X, Li Y, Chen Y and Lin L: m6A-related lncRNAs are potential biomarkers for predicting prognoses and immune responses in patients with LUAD. Mol Ther Nucleic Acids. 24:780–791. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Xu F, Zhan X, Zheng X, Xu H, Li Y, Huang X, Lin L and Chen Y: A signature of immune-related gene pairs predicts oncologic outcomes and response to immunotherapy in lung adenocarcinoma. Genomics. 112:4675–4683. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Cao Y and Tang W and Tang W: Immune cell infiltration characteristics and related core genes in lupus nephritis: Results from bioinformatic analysis. BMC Immunol. 20:372019. View Article : Google Scholar : PubMed/NCBI

22 

Pang C, Guan Y, Li H, Chen W and Zhu G: Urologic cancer in China. Jpn J Clin Oncol. 46:497–501. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Bianchi M, Gandaglia G, Trinh QD, Hansen J, Becker A, Abdollah F, Tian Z, Lughezzani G, Roghmann F, Briganti A, et al: A population-based competing-risks analysis of survival after nephrectomy for renal cell carcinoma. Urol Oncol. 32:46.e1–7. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Funakoshi T, Lee CH and Hsieh JJ: A systematic review of predictive and prognostic biomarkers for VEGF-targeted therapy in renal cell carcinoma. Cancer Treat Rev. 40:533–547. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Peng L, Peng JY, Cai DK, Qiu YT, Lan QS, Luo J, Yang B, Xie HT, Du ZP, Yuan XQ, et al: Immune infiltration and clinical outcome of super-enhancer-associated lncRNAs in stomach adenocarcinoma. Front Oncol. 12:7804932022. View Article : Google Scholar : PubMed/NCBI

26 

Floros T and Tarhini AA: Anticancer cytokines: Biology and clinical effects of interferon-α2, interleukin (IL)-2, IL-15, IL-21, and IL-12. Semin Oncol. 42:539–548. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Mao W, Wang K, Xu B, Zhang H, Sun S, Hu Q, Zhang L, Liu C, Chen S, Wu J, et al: ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma. Mol Cancer. 20:1422021. View Article : Google Scholar : PubMed/NCBI

28 

Chan KK, Matchett KB, Coulter JA, Yuen HF, McCrudden CM, Zhang SD, Irwin GW, Davidson MA, Rülicke T, Schober S, et al: Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Oncotarget. 8:38251–38263. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Tasian SK, Loh ML and Hunger SP: Philadelphia chromosome-like acute lymphoblastic leukemia. Blood. 130:2064–2072. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Fujisue Y, Nakagawa T, Takahara K, Inamoto T, Kiyama S, Azuma H and Asahi M: Induction of erythropoietin increases the cell proliferation rate in a hypoxia-inducible factor-1-dependent and -independent manner in renal cell carcinoma cell lines. Oncol Lett. 5:1765–1770. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Gryko M, Pryczynicz A, Zareba K, Kędra B, Kemona A and Guzińska-Ustymowicz K: The expression of Bcl-2 and BID in gastric cancer cells. J Immunol Res. 2014:9532032014. View Article : Google Scholar : PubMed/NCBI

32 

Rupnarain C, Dlamini Z, Naicker S and Bhoola K: Colon cancer: Genomics and apoptotic events. Biol Chem. 385:449–464. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Fan Y, Wang X and Li Y: IFI30 expression predicts patient prognosis in breast cancer and dictates breast cancer cells proliferation via regulating autophagy. Int J Med Sci. 18:3342–3352. 2021. View Article : Google Scholar : PubMed/NCBI

34 

Yuan Y, Qin H, Li H, Shi W, Bao L, Xu S, Yin J and Zheng L: The functional roles of ISG15/ISGylation in cancer. Molecules. 28:13372023. View Article : Google Scholar : PubMed/NCBI

35 

Qu T, Zhang W, Yan C, Ren D, Wang Y, Guo Y, Guo Q, Wang J, Liu L, Han L, et al: ISG15 targets glycosylated PD-L1 and promotes its degradation to enhance antitumor immune effects in lung adenocarcinoma. J Transl Med. 21:3412023. View Article : Google Scholar : PubMed/NCBI

36 

Lu JF, Hu ZQ, Yang MX, Liu WY, Pan GF, Ding JB, Liu JZ, Tang L, Hu B and Li HC: Downregulation of PDGF-D inhibits proliferation and invasion in breast cancer MDA-MB-231 cells. Clin Breast Cancer. 22:e173–e183. 2022. View Article : Google Scholar : PubMed/NCBI

37 

Yanru W, Zhenyu B, Zhengchuan N, Qi Q, Chunmin L and Weiqiang Y: Transcriptomic analyses of chemokines reveal that down-regulation of XCR1 is associated with advanced hepatocellular carcinoma. Biochem Biophys Res Commun. 496:1314–1321. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Han TD, Shang DH and Tian Y: Docetaxel enhances apoptosis and G2/M cell cycle arrest by suppressing mitogen-activated protein kinase signaling in human renal clear cell carcinoma. Genet Mol Res. 15:2016. View Article : Google Scholar

39 

Sumitomo M, Koizumi F, Asano T, Horiguchi A, Ito K, Asano T, Kakizoe T, Hayakawa M and Matsumura Y: Novel SN-38-incorporated polymeric micelle, NK012, strongly suppresses renal cancer progression. Cancer Res. 68:1631–1635. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, de Souza P, Merchan JR, et al: Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med. 369:722–731. 2013. View Article : Google Scholar : PubMed/NCBI

41 

El-Galley R, Keane TE and Sun C: Camptothecin analogues and vinblastine in the treatment of renal cell carcinoma: An in vivo study using a human orthotopic renal cancer xenograft. Urol Oncol. 21:49–57. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bi Z, Zhou J, Ma Y, Guo Q, Ju B, Zou H, Zhan Z, Yang F, Du H, Gan X, Gan X, et al: Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncol Lett 27: 190, 2024.
APA
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H. ... Song, E. (2024). Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncology Letters, 27, 190. https://doi.org/10.3892/ol.2024.14323
MLA
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H., Zhan, Z., Yang, F., Du, H., Gan, X., Song, E."Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma". Oncology Letters 27.5 (2024): 190.
Chicago
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H., Zhan, Z., Yang, F., Du, H., Gan, X., Song, E."Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma". Oncology Letters 27, no. 5 (2024): 190. https://doi.org/10.3892/ol.2024.14323
Copy and paste a formatted citation
x
Spandidos Publications style
Bi Z, Zhou J, Ma Y, Guo Q, Ju B, Zou H, Zhan Z, Yang F, Du H, Gan X, Gan X, et al: Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncol Lett 27: 190, 2024.
APA
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H. ... Song, E. (2024). Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncology Letters, 27, 190. https://doi.org/10.3892/ol.2024.14323
MLA
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H., Zhan, Z., Yang, F., Du, H., Gan, X., Song, E."Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma". Oncology Letters 27.5 (2024): 190.
Chicago
Bi, Z., Zhou, J., Ma, Y., Guo, Q., Ju, B., Zou, H., Zhan, Z., Yang, F., Du, H., Gan, X., Song, E."Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma". Oncology Letters 27, no. 5 (2024): 190. https://doi.org/10.3892/ol.2024.14323
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team