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Article Open Access

Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis

  • Authors:
    • Qian Ma
    • Bai Wei
    • Bi-Cheng Wang
    • Ganxin Wang
    • Xuan Zhou
    • Yan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, P.R. China, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 192
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    Published online on: March 4, 2024
       https://doi.org/10.3892/ol.2024.14325
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Abstract

As a novel tyrosine kinase inhibitor (TKI), pyrotinib can irreversibly block dual pan‑ErbB receptors and has been used in the treatment of advanced or metastatic human epidermal growth factor receptor 2 (HER2)‑positive breast cancer. However, there are limited data on the use of pyrotinib in early breast cancer. Therefore, the present meta‑analysis was conducted to evaluate the safety and efficacy of pyrotinib in the neoadjuvant setting for patients with early‑stage or locally advanced HER2‑positive breast cancer. Online databases (Pubmed, Web of Science, Embase and Cochrane Library) were comprehensively searched for eligible prospective clinical trials on August 17, 2023. The primary endpoint was the treatment‑related adverse events (TRAEs), and the secondary endpoint was pathological complete response (pCR) rate. In total, seven trials with a total enrolment of 407 patients were included. A total of seven studies evaluated pyrotinib in combination with trastuzumab and chemotherapy in the neoadjuvant setting. The median age ranged from 47‑50 years. The most common TRAEs were diarrhea [98% of patients; 95% confidence interval (CI): 92‑100%], followed by anemia (71%; 95% CI: 55‑89%), vomiting (69%; 95% CI: 55‑82%), and leucopenia (66%; 95% CI: 35‑91%). No treatment‑related deaths occurred. The pooled pCR rate was 57% (95% CI: 47‑68%). It was concluded that pyrotinib‑containing neoadjuvant therapy could be an effective treatment strategy in patients with early‑stage or locally advanced HER2‑positive breast cancer; however, the management of adverse events should be a key consideration. The management of adverse events should be paid great attention to, during pyrotinib therapy, although pyrotinib‑contained neoadjuvant therapy could be an effective treatment for patients with early‑stage or locally advanced HER2‑positive breast cancer. Head‑to‑head randomized clinical trials are warranted to further confirm the benefits and risks associated with pyrotinib therapy in patients with breast cancer.
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Figure 3

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Loibl S and Gianni L: HER2-positive breast cancer. Lancet. 389:2415–2429. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Singh JC, Jhaveri K and Esteva FJ: HER2-positive advanced breast cancer: Optimizing patient outcomes and opportunities for drug development. Br J Cancer. 111:1888–1898. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Wang J and Xu B: Targeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduct Target Ther. 4:342019. View Article : Google Scholar : PubMed/NCBI

5 

Loibl S, Poortmans P, Morrow M, Denkert C and Curigliano G: Breast cancer. Lancet. 397:1750–1769. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, et al: Neoadjuvant chemotherapy, endocrine therapy, and targeted therapy for breast cancer: ASCO guideline. J Clin Oncol. 39:1485–1505. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Spring LM, Fell G, Arfe A, Sharma C, Greenup R, Reynolds KL, Smith BL, Alexander B, Moy B, Isakoff SJ, et al: Pathologic complete response after neoadjuvant chemotherapy and impact on breast cancer recurrence and survival: A comprehensive meta-analysis. Clin Cancer Res. 26:2838–2848. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Li X, Yang C, Wan H, Zhang G, Feng J and Zhang L, Chen X, Zhong D, Lou L, Tao W and Zhang L: Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 110:51–61. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Ma F, Ouyang Q, Li W, Jiang Z, Tong Z, Liu Y, Li H, Yu S, Feng J, Wang S, et al: Pyrotinib or lapatinib combined with capecitabine in HER2-positive metastatic breast cancer with prior taxanes, anthracyclines, and/or trastuzumab: A randomized, phase II study. J Clin Oncol. 37:2610–2619. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Yin S, Chi Y, Du Y, Wang J, Shan C, Yi W, Shang M, Man X, Tan Q and Li H: Efficacy and safety of pyrotinib-containing regimen in the patients with HER2-positive metastatic breast cancer: A multicenter real-world study. Cancer Med. 12:2333–2344. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Yan M, Bian L, Hu X, Zhang Q, Ouyang Q, Feng J, Yin Y, Sun T, Tong Z, Wang X, et al: Pyrotinib plus capecitabine for human epidermal factor receptor 2-positive metastatic breast cancer after trastuzumab and taxanes (PHENIX): A randomized, double-blind, placebo-controlled phase 3 study. Transl Breast Cancer Res. 1:132020. View Article : Google Scholar

12 

Yan M, Ouyang Q, Sun T, Niu L, Yang J, Li L, Song Y, Hao C, Chen Z, Orlandi A, et al: Pyrotinib plus capecitabine for patients with human epidermal growth factor receptor 2-positive breast cancer and brain metastases (PERMEATE): A multicentre, single-arm, two-cohort, phase 2 trial. Lancet Oncol. 23:353–361. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Xu B, Yan M, Ma F, Hu X, Feng J, Ouyang Q, Tong Z, Li H, Zhang Q, Sun T, et al: Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): A multicentre, open-label, randomised, controlled, phase 3 trial. Lancet Oncol. 22:351–360. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Yuan Y, Liu X, Cai Y and Li W: Pyrotinib versus lapatinib therapy for HER2 positive metastatic breast cancer patients after first-line treatment failure: A meta-analysis and systematic review. PLoS One. 18:e02797752023. View Article : Google Scholar : PubMed/NCBI

15 

Blair HA: Pyrotinib: First global approval. Drugs. 78:1751–1755. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, et al: The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 372:n712021. View Article : Google Scholar : PubMed/NCBI

17 

Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y and Chipponi J: Methodological index for non-randomized studies (minors): Development and validation of a new instrument. ANZ J Surg. 73:712–716. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Higgins JPT, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Zhong X, He P, Chen J, Yan X, Wei B, Zhang Z, Bu H, Li J, Tian T, Lv Q, et al: Neoadjuvant pyrotinib plus trastuzumab and nab-paclitaxel for HER2-positive early or locally advanced breast cancer: An exploratory phase II trial. Gland Surg. 11:216–225. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Yin W, Wang Y, Wu Z, Ye Y, Zhou L, Xu S, Lin Y, Du Y, Yan T, Yang F, et al: Neoadjuvant trastuzumab and pyrotinib for locally advanced HER2-positive breast cancer (NeoATP): Primary analysis of a phase II study. Clin Cancer Res. 28:3677–3685. 2022. View Article : Google Scholar : PubMed/NCBI

21 

Liu Z, Wang C, Chen X, Zhu J, Sun X, Xia Q, Lu Z, Qiao J, Zhou Y, Wang H, et al: Pathological response and predictive role of tumour-infiltrating lymphocytes in HER2-positive early breast cancer treated with neoadjuvant pyrotinib plus trastuzumab and chemotherapy (Panphila): A multicentre phase 2 trial. Eur J Cancer. 165:157–168. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Xuhong J, Qi X, Tang P, Fan L, Chen L, Zhang F, Tan X, Yan W, Zhong L, He C, et al: Neoadjuvant pyrotinib plus trastuzumab and chemotherapy for stage I–III HER2-positive breast cancer: A phase II clinical trial. Oncologist. 25:e1909–e1920. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Ding Y, Mo W, Xie X, Wang O, He X, Zhao S, Gu X, Liang C, Qin C, Ding K, et al: Neoadjuvant pyrotinib plus trastuzumab, docetaxel, and carboplatin in early or locally advanced human epidermal receptor 2-positive breast cancer in China: A multicenter, randomized, double-blind, placebo-controlled phase 2 trial. Oncol Res Treat. 46:303–311. 2023. View Article : Google Scholar : PubMed/NCBI

24 

Wu J, Jiang Z, Liu Z, Yang B, Yang H, Tang J, Wang K, Liu Y, Wang H, Fu P, et al: Neoadjuvant pyrotinib, trastuzumab, and docetaxel for HER2-positive breast cancer (PHEDRA): A double-blind, randomized phase 3 trial. BMC Med. 20:4982022. View Article : Google Scholar : PubMed/NCBI

25 

Shi Q, Xuhong J, Luo T, Ge J, Liu F, Lan Y, Chen Q, Tang P, Fan L, Chen L, et al: PIK3CA mutations are associated with pathologic complete response rate to neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2-positive breast cancer. Br J Cancer. 128:121–129. 2023. View Article : Google Scholar : PubMed/NCBI

26 

Guarneri V, Griguolo G, Miglietta F, Conte PF, Dieci MV and Girardi F: Survival after neoadjuvant therapy with trastuzumab-lapatinib and chemotherapy in patients with HER2-positive early breast cancer: A meta-analysis of randomized trials. ESMO Open. 7:1004332022. View Article : Google Scholar : PubMed/NCBI

27 

Zhang J, Yu Y, Lin Y, Kang S, Lv X, Liu Y, Lin J, Wang J and Song C: P079-Efficacy and safety of neoadjuvant therapy for HER2-positive early breast cancer: A network meta-analysis. Breast. 56 (Suppl 1):S49–S50. 2021. View Article : Google Scholar

28 

Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, et al: Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial. Lancet Oncol. 13:25–32. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Shao Z, Pang D, Yang H, Li W, Wang S, Cui S, Liao N, Wang Y, Wang C, Chang YC, et al: Efficacy, safety, and tolerability of pertuzumab, trastuzumab, and docetaxel for patients with early or locally advanced ERBB2-positive breast cancer in Asia: The PEONY phase 3 randomized clinical trial. JAMA Oncol. 6:e1936922020. View Article : Google Scholar : PubMed/NCBI

30 

Hurvitz SA, Martin M, Symmans WF, Jung KH, Huang CS, Thompson AM, Harbeck N, Valero V, Stroyakovskiy D, Wildiers H, et al: Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): A randomised, open-label, multicentre, phase 3 trial. Lancet Oncol. 19:115–126. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Hegg R, Tausch C, Seo JH, Tsai YF, Ratnayake J, et al: Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: A randomized phase II cardiac safety study (TRYPHAENA). Ann Oncol. 24:2278–2284. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Van Sebille YZA, Gibson RJ, Wardill HR and Bowen JM: ErbB small molecule tyrosine kinase inhibitor (TKI) induced diarrhoea: Chloride secretion as a mechanistic hypothesis. Cancer Treat Rev. 41:646–652. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Yusta B, Holland D, Koehler JA, Maziarz M, Estall JL, Higgins R and Drucker DJ: ErbB signaling is required for the proliferative actions of GLP-2 in the murine gut. Gastroenterology. 137:986–996. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Tian C, Wang M, Liu H, Liu J, Xu M and Ma L: Efficacy and safety of neoadjuvant pyrotinib plus docetaxel/liposomal doxorubicin/cyclophosphamide for HER2-positive breast cancer. Ir J Med Sci. 192:1041–1049. 2023. View Article : Google Scholar : PubMed/NCBI

35 

Mao X, Lv P, Gong Y, Wu X, Tang P, Wang S, Zhang D, You W, Wang O, Zhou J, et al: Pyrotinib-containing neoadjuvant therapy in patients with HER2-positive breast cancer: A multicenter retrospective analysis. Front Oncol. 12:8555122022. View Article : Google Scholar : PubMed/NCBI

36 

Li Q, Wang Y, Zhu M, Gu Y and Tang Y: Clinical observation of neoadjuvant chemotherapy with pyrotinib plus trastuzumab in HER2-positive breast cancer: A cohort study. Gland Surg. 10:3389–3402. 2021. View Article : Google Scholar : PubMed/NCBI

37 

Yao DS, Wang W, Chang JY, Zhang Y, Zhang HW, Xu JX and Cai HF: Neoadjuvant pyrotinib plus nab-paclitaxel, doxorubicin, and cyclophosphamide for HER2-positive locally advanced breast cancer: A retrospective case-series study. Gland Surg. 10:3362–3368. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Califano R, Tariq N, Compton S, Fitzgerald DA, Harwood CA, Lal R, Lester J, McPhelim J, Mulatero C, Subramanian S, et al: Expert consensus on the management of adverse events from EGFR tyrosine kinase inhibitors in the UK. Drugs. 75:1335–1348. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Swain SM, Shastry M and Hamilton E: Targeting HER2-positive breast cancer: Advances and future directions. Nat Rev Drug Discov. 22:101–126. 2023. View Article : Google Scholar : PubMed/NCBI

40 

Roy V and Perez EA: Beyond trastuzumab: Small molecule tyrosine kinase inhibitors in HER-2-positive breast cancer. Oncologist. 14:1061–1069. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Kim JW, Lim AR, You JY, Lee JH, Song SE, Lee NK, Jung SP, Cho KR, Kim CY and Park KH: PIK3CA mutation is associated with poor response to HER2-targeted therapy in breast cancer patients. Cancer Res Treat. 55:531–541. 2023. View Article : Google Scholar : PubMed/NCBI

42 

Loibl S, Majewski I, Guarneri V, Nekljudova V, Holmes E, Bria E, Denkert C, Schem C, Sotiriou C, Loi S, et al: PIK3CA mutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: Pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab. Ann Oncol. 27:1519–1525. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Loibl S, von Minckwitz G, Schneeweiss A, Paepke S, Lehmann A, Rezai M, Zahm DM, Sinn P, Khandan F, Eidtmann H, et al: PIK3CA mutations are associated with lower rates of pathologic complete response to anti-human epidermal growth factor receptor 2 (her2) therapy in primary HER2-overexpressing breast cancer. J Clin Oncol. 32:3212–3220. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Ma F, Li Q, Chen S, Zhu W, Fan Y, Wang J, Luo Y, Xing P, Lan B, Li M, et al: Phase I study and biomarker analysis of pyrotinib, a novel irreversible pan-erbb receptor tyrosine kinase inhibitor, in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol. 35:3105–3112. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Hu W, Yang J, Zhang Z, Xu D and Li N: Pyrotinib for HER2-positive metastatic breast cancer: A systematic review and meta-analysis. Transl Cancer Res. 12:247–256. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma Q, Wei B, Wang B, Wang G, Zhou X and Wang Y: Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncol Lett 27: 192, 2024.
APA
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., & Wang, Y. (2024). Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncology Letters, 27, 192. https://doi.org/10.3892/ol.2024.14325
MLA
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., Wang, Y."Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis". Oncology Letters 27.5 (2024): 192.
Chicago
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., Wang, Y."Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis". Oncology Letters 27, no. 5 (2024): 192. https://doi.org/10.3892/ol.2024.14325
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Q, Wei B, Wang B, Wang G, Zhou X and Wang Y: Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncol Lett 27: 192, 2024.
APA
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., & Wang, Y. (2024). Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncology Letters, 27, 192. https://doi.org/10.3892/ol.2024.14325
MLA
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., Wang, Y."Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis". Oncology Letters 27.5 (2024): 192.
Chicago
Ma, Q., Wei, B., Wang, B., Wang, G., Zhou, X., Wang, Y."Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis". Oncology Letters 27, no. 5 (2024): 192. https://doi.org/10.3892/ol.2024.14325
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