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Article

Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment

  • Authors:
    • Hua Ye
    • Wenwen Yu
    • Yangyang Ni
    • Xiaoqiong Bao
    • Xie Zhang
    • Yunlei Li
    • Ali Chen
    • Jifa Li
    • Long Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, Yueqing People's Hospital, Yueqing, Zhejiang 325600, P.R. China, Department of Pulmonary and Critical Care Medicine, Yueqing People's Hospital, Yueqing, Zhejiang 325600, P.R. China
  • Article Number: 194
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    Published online on: March 5, 2024
       https://doi.org/10.3892/ol.2024.14327
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Abstract

Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of apatinib plus chemotherapy in patients with advanced LUAD. A total of 145 patients with advanced LUAD and negative driver genes who received apatinib plus chemotherapy (n=65) or chemotherapy alone (n=80) were analyzed. The overall response rate was significantly improved by apatinib plus chemotherapy vs. chemotherapy alone (53.8 vs. 36.3%; P=0.034). Moreover, progression‑free survival (PFS) was significantly longer in patients who received apatinib plus chemotherapy, compared with those who received chemotherapy alone [median (95% CI), 13.4 months (11.5‑15.3) vs. 8.2 months (6.9‑9.5); P<0.001], as was overall survival (OS) [median (95% CI), 23.1 months (not reached) vs. 17.0 months (14.6‑19.4; P=0.001). Following adjustment by multivariate Cox regression analysis, apatinib plus chemotherapy was associated with a significantly longer PFS [hazard ratio (HR), 0.444; P<0.001] and OS (HR, 0.347; P<0.001), compared with chemotherapy alone. Subgroup analyses revealed that PFS and OS were significantly improved following apatinib plus chemotherapy vs. chemotherapy alone (all P<0.05) in patients receiving first‑ or second‑line treatment. Notably, the incidence of hypertension was significantly increased following apatinib plus chemotherapy vs. chemotherapy alone (43.1 vs. 25.0%; P=0.021), whereas the incidence of other adverse events was not significantly different between the two treatment groups (all P>0.05). In conclusion, apatinib plus chemotherapy is associated with an improved treatment response and survival compared with chemotherapy alone, with a tolerable safety profile in patients with advanced LUAD.
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1 

Seguin L, Durandy M and Feral CC: Lung adenocarcinoma tumor origin: A guide for personalized medicine. Cancers (Basel). 14:17592022. View Article : Google Scholar : PubMed/NCBI

2 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Melocchi V, Dama E, Mazzarelli F, Cuttano R, Colangelo T, Di Candia L, Lugli E, Veronesi G, Pelosi G, Ferretti GM, et al: Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype. Oncogene. 40:4980–4991. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Tan AC and Tan DSW: Targeted therapies for lung cancer patients with oncogenic driver molecular alterations. J Clin Oncol. 40:611–625. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Karimi N and Moghaddam SJ: KRAS-Mutant lung cancer: Targeting molecular and immunologic pathways, therapeutic advantages and restrictions. Cells. 12:7492023. View Article : Google Scholar : PubMed/NCBI

6 

Kim SY, Kim SM, Lim S, Lee JY, Choi SJ, Yang SD, Yun MR, Kim CG, Gu SR, Park C, et al: Modeling clinical responses to targeted therapies by patient-derived organoids of advanced lung adenocarcinoma. Clin Cancer Res. 27:4397–4409. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Lu Y, Fan Z, Zhu SJ, Huang X, Zhuang Z, Li Y, Deng Z, Gao L, Hong X, Zhang T, et al: A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC. EMBO Mol Med. 14:e142962022. View Article : Google Scholar : PubMed/NCBI

8 

Rusdi F, Iskandar H, Hardjianti T, Bakri S, Udaya W, Kasim H, Arief E and Seweng A: The one year survival rate of lung adenocarcinoma patients treated with chemotherapy or targeted therapy. Enfermería Clínica. 30:456–460. 2020. View Article : Google Scholar

9 

Lopez-Chavez A, Thomas A, Rajan A, Raffeld M, Morrow B, Kelly R, Carter CA, Guha U, Killian K, Lau CC, et al: Molecular profiling and targeted therapy for advanced thoracic malignancies: A biomarker-derived, multiarm, multihistology phase II basket trial. J Clin Oncol. 33:1000–1007. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Cui Y, Fang W, Li C, Tang K, Zhang J, Lei Y, He W, Peng S, Kuang M, Zhang H, et al: Development and validation of a novel signature to predict overall survival in ‘Driver Gene-negative’ Lung Adenocarcinoma (LUAD): Results of a multicenter study. Clin Cancer Res. 25:1546–1556. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Gao X, Chen M, Liu X, Shi Y, Liang H, Zhou Q, Zhao J, Pan R, Zhong W, Xu Y and Wang M: Prognostic factors and survival benefits of antitumor treatments for advanced non-small cell lung cancer patients with central nervous system metastasis with or without driver genes: A Chinese single-center cohort study. Front Oncol. 12:8795542022. View Article : Google Scholar : PubMed/NCBI

12 

Hames ML, Chen H, Iams W, Aston J, Lovly CM and Horn L: Correlation between KRAS mutation status and response to chemotherapy in patients with advanced non-small cell lung cancer☆. Lung Cancer. 92:29–34. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Scott LJ: Apatinib: A review in advanced gastric cancer and other advanced cancers. Drugs. 78:747–758. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Cui YJ, Liu J, Liu MM and Zhang HZ: Observation on the clinical effect of apatinib combined with chemotherapy in the treatment of advanced non-small cell lung cancer. Pak J Med Sci. 37:1036–1041. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Hu R, Li T, Hui K, Chen Z, Wang N, Wu X, Ge L and Zhou L: Apatinib sensitizes chemoresistant NSCLC cells to doxetaxel via regulating autophagy and enhances the therapeutic efficacy in advanced and refractory/recurrent NSCLC. Mol Med Rep. 22:3935–3943. 2020.PubMed/NCBI

16 

Yu Z, Cai X, Xu Z, He Z, Lai J, Wang W, Zhang J, Kong W, Huang X, Chen Y, et al: Apatinib plus chemotherapy as a second-line treatment in unresectable non-small cell lung carcinoma: A randomized, controlled, multicenter clinical trial. Oncologist. 25:e1640–e1649. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Cainap C, Balacescu O, Cainap SS and Pop LA: Next generation sequencing technology in lung cancer diagnosis. Biology (Basel). 10:8642021.PubMed/NCBI

18 

Chansky K, Detterbeck FC, Nicholson AG, Rusch VW, Vallières E, Groome P, Kennedy C, Krasnik M, Peake M, Shemanski L, et al: The IASLC lung cancer staging project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer. J Thorac Oncol. 12:1109–1121. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, et al: Non-Small cell lung cancer, version 5.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:504–535. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, Dancey J, Arbuck S, Gwyther S, Mooney M, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Freites-Martinez A, Santana N, Arias-Santiago S and Viera A: Using the common terminology criteria for adverse events (CTCAE – Version 5.0) to Evaluate the severity of adverse events of anticancer therapies. Actas Dermosifiliogr (Engl Ed). 112:90–92. 2021.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

22 

Azam F, Latif MF, Farooq A, Tirmazy SH, AlShahrani S, Bashir S and Bukhari N: Performance status assessment by using ECOG (Eastern Cooperative Oncology Group) Score for cancer patients by oncology healthcare professionals. Case Rep Oncol. 12:728–736. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Jiang Q, Zhang NL, Ma DY, Tan BX, Hu X and Fang XD: Efficacy and safety of apatinib plus docetaxel as the second or above line treatment in advanced nonsquamous NSCLC: A multi center prospective study. Medicine (Baltimore). 98:e160652019. View Article : Google Scholar : PubMed/NCBI

24 

Xu J, Liu X, Yang S and Shi Y: Efficacy, safety, and prognostic factors of apatinib plus platinum doublet chemotherapy in advanced non-small cell lung cancer. J Cancer Res Ther. 18:1425–1431. 2022. View Article : Google Scholar : PubMed/NCBI

25 

Huang MP, Gu SZ, Huang B, Li GW, Xiong ZP, Tang T and Zeng SN: Apatinib inhibits angiogenesis in intrahepatic cholangiocarcinoma by regulating the vascular endothelial growth factor receptor-2/signal transducer and activator of transcription factor 3/hypoxia inducible factor 1 subunit alpha signaling axis. Pharmacology. 106:509–519. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Song J, Guan Z, Song C, Li M, Gao Z and Zhao Y: Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways. Mol Med Rep. 23:4292021. View Article : Google Scholar : PubMed/NCBI

27 

Hu Y, Jing J, Shi Y, Zhang P, Dong D, Wu Y, Dong X, Li E and Fan Y: Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways. Transl Cancer Res. 10:3306–3316. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J and Zhong C: Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer. J Exp Clin Cancer Res. 40:2662021. View Article : Google Scholar : PubMed/NCBI

29 

Liu ZL, Jin BJ, Cheng CG, Zhang FX, Wang SW, Wang Y and Wu B: Apatinib resensitizes cisplatin-resistant non-small cell lung carcinoma A549 cell through reversing multidrug resistance and suppressing ERK signaling pathway. Eur Rev Med Pharmacol Sci. 21:5370–5377. 2017.PubMed/NCBI

30 

Zhang X, Xiong Y, Xia Q, Wu F, Liu L, Zhou Y, Zeng L, Zhou C, Xia C, Jiang W, et al: Efficacy and safety of apatinib plus vinorelbine in patients with wild-type advanced non-small cell lung cancer after second-line treatment failure: A nonrandomized clinical trial. JAMA Netw Open. 3:e2012262020. View Article : Google Scholar : PubMed/NCBI

31 

Wang W, He Q, Li C, Zhuang C, Zhang H, Wang Q, Fan X, Qi M, Sun R and Yu J: Research on the mechanism and prevention of hypertension caused by apatinib through the RhoA/ROCK signaling pathway in a mouse model of gastric cancer. Front Cardiovasc Med. 9:8738292022. View Article : Google Scholar : PubMed/NCBI

32 

Cohen JB, Brown NJ, Brown SA, Dent S, van Dorst DCH, Herrmann SM, Lang NN, Oudit GY, Touyz RM; American Heart Association Council on Hypertension, ; et al: Cancer therapy-related hypertension: A scientific statement from the american heart association. Hypertension. 80:e46–e57. 2023. View Article : Google Scholar : PubMed/NCBI

33 

Camarda N, Travers R, Yang VK, London C and Jaffe IZ: VEGF receptor inhibitor-induced hypertension: Emerging mechanisms and clinical implications. Curr Oncol Rep. 24:463–474. 2022. View Article : Google Scholar : PubMed/NCBI

34 

Caletti S, Paini A, Coschignano MA, De Ciuceis C, Nardin M, Zulli R, Muiesan ML, Salvetti M and Rizzoni D: Management of VEGF-Targeted therapy-induced hypertension. Curr Hypertens Rep. 20:682018. View Article : Google Scholar : PubMed/NCBI

35 

Maitland ML, Bakris GL, Black HR, Chen HX, Durand JB, Elliott WJ, Ivy SP, Leier CV, Lindenfeld J, Liu G, et al: Initial assessment, surveillance, and management of blood pressure in patients receiving vascular endothelial growth factor signaling pathway inhibitors. J Natl Cancer Inst. 102:596–604. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Patel S, Dushenkov A, Jungsuwadee P, Krishnaswami A and Barac A: Team-Based approach to management of hypertension associated with angiogenesis inhibitors. J Cardiovasc Transl Res. 13:463–477. 2020. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye H, Yu W, Ni Y, Bao X, Zhang X, Li Y, Chen A, Li J and Zheng L: Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncol Lett 27: 194, 2024.
APA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y. ... Zheng, L. (2024). Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncology Letters, 27, 194. https://doi.org/10.3892/ol.2024.14327
MLA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27.5 (2024): 194.
Chicago
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27, no. 5 (2024): 194. https://doi.org/10.3892/ol.2024.14327
Copy and paste a formatted citation
x
Spandidos Publications style
Ye H, Yu W, Ni Y, Bao X, Zhang X, Li Y, Chen A, Li J and Zheng L: Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncol Lett 27: 194, 2024.
APA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y. ... Zheng, L. (2024). Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncology Letters, 27, 194. https://doi.org/10.3892/ol.2024.14327
MLA
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27.5 (2024): 194.
Chicago
Ye, H., Yu, W., Ni, Y., Bao, X., Zhang, X., Li, Y., Chen, A., Li, J., Zheng, L."Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment". Oncology Letters 27, no. 5 (2024): 194. https://doi.org/10.3892/ol.2024.14327
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