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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May-2024 Volume 27 Issue 5

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Case Report

Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report

  • Authors:
    • David Luengo
    • Ángela Salmerón
    • Antonio Medina
    • Javier Pastor
    • Mercedes Caba
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Virgen de las Nieves University Hospital, 18014 Granada, Spain, Department of Pathological Anatomy, San Cecilio University Hospital, 18016 Granada, Spain
  • Article Number: 195
    |
    Published online on: March 5, 2024
       https://doi.org/10.3892/ol.2024.14328
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Abstract

Retroperitoneal fibrosis, a rare and often idiopathic condition, poses significant diagnostic challenges. While most cases are considered idiopathic or immune‑mediated, a small but important proportion are associated with malignant neoplasms, with implications for prognosis and management. The present study describes the case of a 69‑year‑old man who presented to the emergency department of the Virgen de las Nieves University Hospital (Granada, Spain), with a 2‑week history of epigastric pain, vomiting and altered bowel habits. Laboratory investigations revealed previously undiagnosed renal insufficiency. An abdominal computed tomography (CT) scan showed extensive diffuse retroperitoneal infiltration extending from the periduodenal region to the pubic bone, resulting in gastric dilatation and hydronephrosis. A CT‑guided retroperitoneal biopsy was performed and pathology confirmed the presence of urothelial carcinoma. This diagnosis led to the initiation of a chemotherapy regimen consisting of carboplatin and gemcitabine specifically designed for urothelial carcinoma. A follow‑up 18F‑FDG PET scan performed 6 months later showed a partial functional response. This case illustrates a rare presentation of urothelial carcinoma masked by extensive retroperitoneal fibrosis, and highlights the importance of accurate diagnosis in reducing tumor burden and improving the clinical status of patients.
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1 

Vaglio A, Salvarani C and Buzio C: Retroperitoneal fibrosis. Lancet. 367:241–251. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Amis ES Jr: Retroperitoneal fibrosis. AJR Am J Roentgenol. 157:321–329. 1991. View Article : Google Scholar : PubMed/NCBI

3 

Caiafa RO, Vinuesa AS, Izquierdo RS, Brufau BP, Ayuso Colella JR and Molina CN: Retroperitoneal fibrosis: Role of imaging in diagnosis and follow-up. Radiographics. 33:535–552. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Koep L and Zuidema GD: The clinical significance of retroperitoneal fibrosis. Surgery. 81:250–257. 1977.PubMed/NCBI

5 

Reiner I, Yachia D, Nissim F and Fishelowitz Y: Retroperitoneal fibrosis in association with urothelial tumor. J Urol. 132:115–116. 1984. View Article : Google Scholar : PubMed/NCBI

6 

Murray SM and Woo-Ming MO: Retroperitoneal ‘fibrosis’ due to carcinoma of the ureter. Br J Urol. 38:424–427. 1966. View Article : Google Scholar : PubMed/NCBI

7 

Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME and Wiltshaw E: Carboplatin dosage: Prospective evaluation of a simple formula based on renal function. J Clin Oncol. 7:1748–1756. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Stillwell TJ, Rife CC and Lieber MM: Bladder carcinoma presenting with rectal obstruction. Urology. 34:238–240. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Tokunaga K, Furuta A, Arizono S, Teramoto Y, Negoro H, Kido A, Isoda H and Togashi K: Duodenal obstruction induced by retroperitoneal progression of bladder cancer: A report of two cases. Abdom Radiol (NY). 44:1223–1229. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Iwamoto N, Oikawa M, Kukimoto T, Ito J, Murakami K and Kaiho Y: Renal pelvis cancer with initial symptoms of malignant gastric outlet obstruction. IJU Case Rep. 6:475–478. 2023. View Article : Google Scholar : PubMed/NCBI

11 

Andersen K, Burroughs S, Munis A, Hoff RT and Shapiro A: Gastric outlet obstruction as the initial presentation of upper tract urothelial carcinoma. Case Rep Gastrointest Med. 2020:88500622020.PubMed/NCBI

12 

Brandt AS, Kamper L, Kukuk S, Haage P and Roth S: Associated findings and complications of retroperitoneal fibrosis in 204 patients: Results of a urological registry. J Urol. 185:526–531. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Lee SJ, Eun JS, Kim MJ, Song YW and Kang Y: Association of retroperitoneal fibrosis with malignancy and its outcomes. Arthritis Res Ther. 23:2492021. View Article : Google Scholar : PubMed/NCBI

14 

Brun B, Laursen K, Sørensen IN, Lorentzen JE and Kristensen JK: CT in retroperitoneal fibrosis. AJR Am J Roentgenol. 137:535–538. 1981. View Article : Google Scholar : PubMed/NCBI

15 

Fagan CJ, Larrieu AJ and Amparo EG: Retroperitoneal fibrosis: Ultrasound and CT features. AJR Am J Roentgenol. 133:239–243. 1979. View Article : Google Scholar : PubMed/NCBI

16 

Yeung KT and Yang J: Epithelial-mesenchymal transition in tumor metastasis. Mol Oncol. 11:28–39. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Brandt AS, Dreger NM, Müller E, Kukuk S and Roth S: New (and old) aspects of retroperitoneal fibrosis. Urologe A. 56:887–894. 2017.(In German). View Article : Google Scholar : PubMed/NCBI

18 

Łoń I, Wieliczko M, Lewandowski J and Małyszko J: Retroperitoneal fibrosis is still an underdiagnosed entity with poor prognosis. Kidney Blood Press Res. 47:151–162. 2022. View Article : Google Scholar : PubMed/NCBI

19 

Cronin CG, Lohan DG, Blake MA, Roche C, McCarthy P and Murphy JM: Retroperitoneal fibrosis: A review of clinical features and imaging findings. AJR Am J Roentgenol. 191:423–431. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, et al: European association of urology guidelines on muscle-invasive and metastatic bladder cancer: Summary of the 2023 guidelines. Eur Urol. 85:17–31. 2024. View Article : Google Scholar : PubMed/NCBI

21 

Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, et al: European association of urology guidelines on upper urinary tract urothelial carcinoma: 2023 Update. Eur Urol. 84:49–64. 2023. View Article : Google Scholar : PubMed/NCBI

22 

Cathomas R, Lorch A, Bruins HM, Compérat EM, Cowan NC, Efstathiou JA, Fietkau R, Gakis G, Hernández V, Espinós EL, et al: The 2021 updated European association of urology guidelines on metastatic urothelial carcinoma. Eur Urol. 81:95–103. 2022. View Article : Google Scholar : PubMed/NCBI

23 

Geynisman DM, Broughton E, Hao Y, Zhang Y, Le T and Huo S: Real-world treatment patterns and clinical outcomes among patients with advanced urothelial carcinoma in the United States. Urol Oncol. 40:195.e1–195.e11. 2022. View Article : Google Scholar : PubMed/NCBI

24 

Dogliotti L, Cartenì G, Siena S, Bertetto O, Martoni A, Bono A, Amadori D, Onat H and Marini L: Gemcitabine plus cisplatin versus gemcitabine plus carboplatin as first-line chemotherapy in advanced transitional cell carcinoma of the urothelium: Results of a Randomized phase 2 trial. Eur Urol. 52:134–141. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Luengo D, Salmerón Á, Medina A, Pastor J and Caba M: Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncol Lett 27: 195, 2024.
APA
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., & Caba, M. (2024). Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncology Letters, 27, 195. https://doi.org/10.3892/ol.2024.14328
MLA
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., Caba, M."Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report". Oncology Letters 27.5 (2024): 195.
Chicago
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., Caba, M."Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report". Oncology Letters 27, no. 5 (2024): 195. https://doi.org/10.3892/ol.2024.14328
Copy and paste a formatted citation
x
Spandidos Publications style
Luengo D, Salmerón Á, Medina A, Pastor J and Caba M: Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncol Lett 27: 195, 2024.
APA
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., & Caba, M. (2024). Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncology Letters, 27, 195. https://doi.org/10.3892/ol.2024.14328
MLA
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., Caba, M."Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report". Oncology Letters 27.5 (2024): 195.
Chicago
Luengo, D., Salmerón, Á., Medina, A., Pastor, J., Caba, M."Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report". Oncology Letters 27, no. 5 (2024): 195. https://doi.org/10.3892/ol.2024.14328
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