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Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience

  • Authors:
    • Mirosława Püsküllüoğlu
    • Katarzyna Swiderska
    • Aleksandra Konieczna
    • Joanna Streb
    • Aleksandra Grela‑Wojewoda
    • Agnieszka Rudzinska
    • Jolanta Dobrzańska
    • Renata Pacholczak‑Madej
    • Anna Mucha‑Malecka
    • Michał Kunkiel
    • Jerzy W. Mitus
    • Michał Jarząb
    • Marek Ziobro
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, Maria Sklodowska‑Curie National Research Institute of Oncology, Krakow Branch, 31‑115 Krakow, Poland, Breast Cancer Unit, Maria Skłodowska‑Curie National Research Institute of Oncology, Gliwice Branch, 44‑102 Gliwice, Poland, Department of Breast Cancer and Reconstructive Surgery, Maria Sklodowska‑Curie National Research Institute of Oncology in Warsaw, 02‑781 Warsaw, Poland, Department of Oncology, Jagiellonian University Medical College, 31‑008 Krakow, Poland, Department of Oncology, University Hospital, 30‑688 Krakow, Poland, Department of Anatomy, Jagiellonian University Medical College, 31‑008 Krakow, Poland, Department of Radiotherapy, Maria Sklodowska‑Curie National Research Institute of Oncology, Krakow Branch, 31‑115 Krakow, Poland
    Copyright: © Püsküllüoğlu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 198
    |
    Published online on: March 8, 2024
       https://doi.org/10.3892/ol.2024.14331
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Abstract

Metaplastic breast cancer (BC‑Mp), which includes a range of epithelial and mixed epithelial‑mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC‑Mp focuses mainly on retrospective data for radically treated patients. Notably absent are studies dedicated to the palliative treatment of BC‑Mp with distant metastases. The present retrospective study investigated treatment modalities and prognosis in a multi‑centre cohort of 31 female participants diagnosed with distant metastatic BC‑Mp, including 7 patients with de novo metastatic disease. The median age of the patients was 61 years (range, 33‑87 years), with 38.7% presenting local lymph node involvement. Lungs were the most common site for the metastatic disease (61.3%). Median Ki‑67 index was 50% (range, 35‑70%), and 80.7% of cases were classified as grade 3. Human epidermal growth factor receptor 2 (HER2)+ and estrogen receptor+ were detected in 12.9 and 6.5% of cases, respectively. A total of 62.4% of patients received first‑line palliative systemic treatment. The 1‑ and 2‑year overall survival (OS) were 38.5 and 19.2%, respectively. Receiving ≥1 line of palliative treatment was significantly associated with improved OS (P<0.001). Factors such as age, Ki‑67 index, HER2 or hormonal status, presence of specific epithelial or mesenchymal components, location of metastases or chemotherapy regimen type did not influence OS. The present study provided insights into the clinicopathological profile, systemic treatment experience, prognostic factors and OS data of BC‑Mp with distant metastases, emphasizing the imperative for clinical trials in this population.
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Spandidos Publications style
Püsküllüoğlu M, Swiderska K, Konieczna A, Streb J, Grela‑Wojewoda A, Rudzinska A, Dobrzańska J, Pacholczak‑Madej R, Mucha‑Malecka A, Kunkiel M, Kunkiel M, et al: Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience. Oncol Lett 27: 198, 2024.
APA
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A. ... Ziobro, M. (2024). Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience. Oncology Letters, 27, 198. https://doi.org/10.3892/ol.2024.14331
MLA
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A., Dobrzańska, J., Pacholczak‑Madej, R., Mucha‑Malecka, A., Kunkiel, M., Mitus, J. W., Jarząb, M., Ziobro, M."Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience". Oncology Letters 27.5 (2024): 198.
Chicago
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A., Dobrzańska, J., Pacholczak‑Madej, R., Mucha‑Malecka, A., Kunkiel, M., Mitus, J. W., Jarząb, M., Ziobro, M."Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience". Oncology Letters 27, no. 5 (2024): 198. https://doi.org/10.3892/ol.2024.14331
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Spandidos Publications style
Püsküllüoğlu M, Swiderska K, Konieczna A, Streb J, Grela‑Wojewoda A, Rudzinska A, Dobrzańska J, Pacholczak‑Madej R, Mucha‑Malecka A, Kunkiel M, Kunkiel M, et al: Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience. Oncol Lett 27: 198, 2024.
APA
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A. ... Ziobro, M. (2024). Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience. Oncology Letters, 27, 198. https://doi.org/10.3892/ol.2024.14331
MLA
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A., Dobrzańska, J., Pacholczak‑Madej, R., Mucha‑Malecka, A., Kunkiel, M., Mitus, J. W., Jarząb, M., Ziobro, M."Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience". Oncology Letters 27.5 (2024): 198.
Chicago
Püsküllüoğlu, M., Swiderska, K., Konieczna, A., Streb, J., Grela‑Wojewoda, A., Rudzinska, A., Dobrzańska, J., Pacholczak‑Madej, R., Mucha‑Malecka, A., Kunkiel, M., Mitus, J. W., Jarząb, M., Ziobro, M."Clinical analysis of metaplastic breast carcinoma with distant metastases: A multi‑centre experience". Oncology Letters 27, no. 5 (2024): 198. https://doi.org/10.3892/ol.2024.14331
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