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Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis

  • Authors:
    • Lei Zhu
    • Jie Zhang
    • Hongxia Zhou
    • Guanqi Zhang
    • Bin Wang
    • Haolong Qi
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China, Department of Thyroid Breast Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 199
    |
    Published online on: March 8, 2024
       https://doi.org/10.3892/ol.2024.14332
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Abstract

The novel long non‑coding RNA, EGFR‑AS1, is expressed in various types of solid tumour, and its oncogenic role has been fully identified. In the present study, several articles were screened following an electronic search of the PubMed database. In total, 8 studies were included in the present systematic review. For each analysis indicator risk ratios (RRs) with 95% confidence intervals (CIs) or hazard ratios (HRs) with standard errors and 95% CIs were estimated using Review Manager 5.3. The pooled RR of high EGFR‑AS1 expression among patients with or without vascular invasion was 1.81 with a 95% CI of 1.22‑2.69; the pooled HR of high EGFR‑AS1 expression for patient overall survival rate was 1.74 with a 95% CI of 1.39‑2.18. Therefore, EGFR‑AS1 was identified as an oncogene and the upregulated EGFR‑AS1 expression was significantly associated with advanced tumour progression and poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu L, Zhang J, Zhou H, Zhang G, Wang B and Qi H: Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis. Oncol Lett 27: 199, 2024.
APA
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., & Qi, H. (2024). Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis. Oncology Letters, 27, 199. https://doi.org/10.3892/ol.2024.14332
MLA
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., Qi, H."Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis". Oncology Letters 27.5 (2024): 199.
Chicago
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., Qi, H."Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis". Oncology Letters 27, no. 5 (2024): 199. https://doi.org/10.3892/ol.2024.14332
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu L, Zhang J, Zhou H, Zhang G, Wang B and Qi H: Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis. Oncol Lett 27: 199, 2024.
APA
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., & Qi, H. (2024). Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis. Oncology Letters, 27, 199. https://doi.org/10.3892/ol.2024.14332
MLA
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., Qi, H."Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis". Oncology Letters 27.5 (2024): 199.
Chicago
Zhu, L., Zhang, J., Zhou, H., Zhang, G., Wang, B., Qi, H."Clinical role of the long non‑coding RNA, EGFR‑AS1, in patients with cancer: A systematic review and meta‑analysis". Oncology Letters 27, no. 5 (2024): 199. https://doi.org/10.3892/ol.2024.14332
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