Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer

  • Authors:
    • Qinqin Zhang
    • Rongzhao Lu
    • Ying Wu
    • Yong Hong
    • Ningxia Wang
    • Cunchuan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, School of Clinical Medicine, Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541001, P.R. China, Department of Thyroid and Breast Surgery, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi Zhuang Autonomous Region 541002, P.R. China, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 209
    |
    Published online on: March 14, 2024
       https://doi.org/10.3892/ol.2024.14342
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Breast cancer (BC) is the most common type of malignancy and the leading cause of cancer‑associated mortality in women worldwide. As such, assessing the metabolic changes during human breast carcinogenesis is key for developing disease prevention methods and treatment. In the present study, non‑targeted metabolomics with chemometrics based on ultra‑high performance liquid chromatography‑high‑resolution mass spectrometry were performed to assess differences in serum metabolite patterns between patients with BC and healthy individuals. A total of 3,246 metabolites in the sera of healthy controls and patients with BC were found. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that arginine, proline, nicotinate, nicotinamide, caffeine and arachidonic acid metabolism, as well as fatty acid biosynthesis were significantly altered in patients with BC in comparison with controls. These results suggested that serum metabolic profiling has potential for discovering molecular biomarkers for the detection of BC. It may also further the understanding of the underlying mechanisms associated with this disease.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S and Soerjomataram I: Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 66:15–23. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Fakhri N, Chad MA, Lahkim M, Houari A, Dehbi H, Belmouden A and El Kadmiri N: Risk factors for breast cancer in women: An update review. Med Oncol. 39:1972022. View Article : Google Scholar : PubMed/NCBI

4 

Derakhshan F and Reis-Filho JS: Pathogenesis of triple-negative breast cancer. Annu Rev Pathol. 17:181–204. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Wong GL, Manore SG, Doheny DL and Lo HW: STAT family of transcription factors in breast cancer: Pathogenesis and therapeutic opportunities and challenges. Semin Cancer Biol. 86:84–106. 2022. View Article : Google Scholar : PubMed/NCBI

6 

Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI

7 

Li S, Zeng H, Fan J, Wang F, Xu C, Li Y, Tu J, Nephew KP and Long X: Glutamine metabolism in breast cancer and possible therapeutic targets. Biochem Pharmacol. 210:1154642023. View Article : Google Scholar : PubMed/NCBI

8 

Hamam R, Hamam D, Alsaleh KA, Kassem M, Zaher W, Alfayez M, Aldahmash A and Alajez NM: Circulating microRNAs in breast cancer: Novel diagnostic and prognostic biomarkers. Cell Death Dis. 8:e30452017. View Article : Google Scholar : PubMed/NCBI

9 

Gyamfi J, Kim J and Choi J: Cancer as a metabolic disorder. Int J Mol Sci. 23:11552022. View Article : Google Scholar : PubMed/NCBI

10 

Ling ZN, Jiang YF, Ru JN, Lu JH, Ding B and Wu J: Amino acid metabolism in health and disease. Signal Transduct Target Ther. 8:3452023. View Article : Google Scholar : PubMed/NCBI

11 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Guan Q, Liang S, Wang Z, Yang Y and Wang S: ¹H NMR-based metabonomic analysis of the effect of optimized rhubarb aglycone on the plasma and urine metabolic fingerprints of focal cerebral ischemia-reperfusion rats. J Ethnopharmacol. 154:65–75. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Dudzik D, Barbas-Bernardos C, García A and Barbas C: Quality assurance procedures for mass spectrometry untargeted metabolomics. a review. J Pharm Biomed Anal. 147:149–173. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Huang S, Chong N, Lewis NE, Jia W, Xie G and Garmire LX: Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis. Genome Med. 8:342016. View Article : Google Scholar : PubMed/NCBI

15 

Ogrodzinski MP, Teoh ST and Lunt SY: Metabolomic profiling of mouse mammary tumor-derived cell lines reveals targeted therapy options for cancer subtypes. Cell Oncol (Dordr). 43:1117–1127. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Araújo R, Bispo D, Helguero LA and Gil AM: Metabolomic studies of breast cancer in murine models: A review. Biochim Biophys Acta Mol Basis Dis. 1866:1657132020. View Article : Google Scholar : PubMed/NCBI

17 

Sharma U and Jagannathan NR: Magnetic resonance imaging (MRI) and MR spectroscopic methods in understanding breast cancer biology and metabolism. Metabolites. 12:2952022. View Article : Google Scholar : PubMed/NCBI

18 

Choi MH: Mass spectrometry-based metabolic signatures of sex steroids in breast cancer. Mol Cell Endocrinol. 466:81–85. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, et al: Systems biology guided by XCMS Online metabolomics. Nat Methods. 14:461–462. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Yuan M, Breitkopf SB, Yang X and Asara JM: A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue. Nat Protoc. 7:872–881. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Griffin JL and Shockcor JP: Metabolic profiles of cancer cells. Nat Rev Cancer. 4:551–561. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Kim YS, Maruvada P and Milner JA: Metabolomics in biomarker discovery: Future uses for cancer prevention. Future Oncol. 4:93–102. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Spratlin JL, Serkova NJ and Eckhardt SG: Clinical applications of metabolomics in oncology: A review. Clin Cancer Res. 15:431–440. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Mishra P and Ambs S: Metabolic signatures of human breast cancer. Mol Cell Oncol. 3:e9922172015. View Article : Google Scholar : PubMed/NCBI

25 

Johnson CH, Manna SK, Krausz KW, Bonzo JA, Divelbiss RD, Hollingshead MG and Gonzalez FJ: Global metabolomics reveals urinary biomarkers of breast cancer in a mcf-7 ×enograft mouse model. Metabolites. 3:658–672. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Johnson CH, Patterson AD, Idle JR and Gonzalez FJ: Xenobiotic metabolomics: Major impact on the metabolome. Annu Rev Pharmacol Toxicol. 52:37–56. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Szefel J, Danielak A and Kruszewski WJ: Metabolic pathways of L-arginine and therapeutic consequences in tumors. Adv Med Sci. 64:104–110. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Hu L, Gao Y, Cao Y, Zhang Y, Xu M, Wang Y, Jing Y, Guo S, Jing F, Hu X and Zhu Z: Identification of arginine and its ‘Downstream’ molecules as potential markers of breast cancer. IUBMB Life. 68:817–822. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Kim S, Lee M, Song Y, Lee SY, Choi I, Park IS, Kim J, Kim JS, Kim KM and Seo HR: Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma. J Exp Clin Cancer Res. 40:1272021. View Article : Google Scholar : PubMed/NCBI

30 

Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, Gaur S, Forman HJ, Zhang H, Zheng S, et al: Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal. 7:ra312014. View Article : Google Scholar : PubMed/NCBI

31 

Park KG, Heys SD, Harris CI, Steele RJ, McNurlan MA, Eremin O and Garlick PJ: Arginine metabolism in benign and malignant disease of breast and colon: Evidence for possible inhibition of tumor-infiltrating macrophages. Nutrition. 7:185–188. 1991.PubMed/NCBI

32 

Vissers YL, Dejong CH, Luiking YC, Fearon KC, von Meyenfeldt MF and Deutz NE: Plasma arginine concentrations are reduced in cancer patients: Evidence for arginine deficiency? Am J Clin Nutr. 81:1142–1146. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Geng D, Sun D, Zhang L and Zhang W: The therapy of gefitinib towards breast cancer partially through reversing breast cancer biomarker arginine. Afr Health Sci. 15:594–597. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Navas LE and Carnero A: Nicotinamide adenine dinucleotide (NAD) metabolism as a relevant target in cancer. Cells. 11:26272022. View Article : Google Scholar : PubMed/NCBI

35 

Yin J, Ren W, Huang X, Deng J, Li T and Yin Y: Potential mechanisms connecting purine metabolism and cancer therapy. Front Immunol. 9:16972018. View Article : Google Scholar : PubMed/NCBI

36 

Ortea I, González-Fernández MJ, Ramos-Bueno RP and Guil-Guerrero JL: Proteomics study reveals that docosahexaenoic and arachidonic acids exert different in vitro anticancer activities in colorectal cancer cells. J Agric Food Chem. 66:6003–6012. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Chan TA, Morin PJ, Vogelstein B and Kinzler KW: Mechanisms underlying nonsteroidal antiinflammatory drug-mediatedapoptosis. Proc Natl Acad Sci USA. 95:681–686. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Li W, Guo X, Chen C and Li J: The prognostic value of arachidonic acid metabolism in breast cancer by integrated bioinformatics. Lipids Health Dis. 21:1032022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Lu R, Wu Y, Hong Y, Wang N and Wang C: Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. Oncol Lett 27: 209, 2024.
APA
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., & Wang, C. (2024). Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. Oncology Letters, 27, 209. https://doi.org/10.3892/ol.2024.14342
MLA
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., Wang, C."Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer". Oncology Letters 27.5 (2024): 209.
Chicago
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., Wang, C."Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer". Oncology Letters 27, no. 5 (2024): 209. https://doi.org/10.3892/ol.2024.14342
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Lu R, Wu Y, Hong Y, Wang N and Wang C: Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. Oncol Lett 27: 209, 2024.
APA
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., & Wang, C. (2024). Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. Oncology Letters, 27, 209. https://doi.org/10.3892/ol.2024.14342
MLA
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., Wang, C."Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer". Oncology Letters 27.5 (2024): 209.
Chicago
Zhang, Q., Lu, R., Wu, Y., Hong, Y., Wang, N., Wang, C."Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer". Oncology Letters 27, no. 5 (2024): 209. https://doi.org/10.3892/ol.2024.14342
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team