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Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study

  • Authors:
    • Yoon Jung Jang
    • Hong Kyu Jeong
    • Chang-Bae Kong
    • Won Seoκ Song
    • Wan Hyeong Cho
    • Dae Geun Jeon
    • Heyjin Kim
    • Sung Hyun Yang
    • Im Il Na
    • Hyo-Rak Lee
    • Hye Jin Kang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea, Department of Orthopedic Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea, Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea
    Copyright: © Jang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 211
    |
    Published online on: March 14, 2024
       https://doi.org/10.3892/ol.2024.14344
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Abstract

The present retrospective study investigated the clinical features and prognosis of secondary hematological malignancies (SHMs) in patients with sarcoma at Korea Cancer Center Hospital (Seoul, South Korea). Patients who had been diagnosed with SHMs after having received treatment for sarcoma between January 2000 and May 2023 were enrolled. Clinical data were collected from the patients' medical records. Clinical characteristics were analyzed, including SHM incidence, type and prognosis. Of 2,953 patients with sarcoma, 18 (0.6%) were diagnosed with SHMs. Their median age at the time of sarcoma diagnosis was 39.5 (range, 9‑72) years, and 74% (n=14) of these patients were male. The histological features of sarcoma varied, with osteosarcoma diagnosed in nine patients (50%). All patients with sarcoma underwent surgical treatment, and 16 (88.8%) received chemotherapy. The most common type of SHMs was acute myeloid leukemia (n=6; 33.3%), followed by myelodysplastic syndrome (n=5; 27.7%). The median latency period between the sarcoma diagnosis and SHM identification was 30 (range, 11‑121) months. A total of 13 (72.2%) patients received treatment for the SHM. The median overall survival after SHM diagnosis was 15.7 (range, 0.4‑154.9) months. The incidence of SHMs in sarcoma in the present study was consistent with that reported previously. The presence of SHMs was associated with a poor patient prognosis, especially if treatment for SHMs was not administered.
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Copy and paste a formatted citation
Spandidos Publications style
Jang YJ, Jeong HK, Kong C, Song WS, Cho WH, Jeon DG, Kim H, Yang SH, Na II, Lee H, Lee H, et al: Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study. Oncol Lett 27: 211, 2024.
APA
Jang, Y.J., Jeong, H.K., Kong, C., Song, W.S., Cho, W.H., Jeon, D.G. ... Kang, H.J. (2024). Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study. Oncology Letters, 27, 211. https://doi.org/10.3892/ol.2024.14344
MLA
Jang, Y. J., Jeong, H. K., Kong, C., Song, W. S., Cho, W. H., Jeon, D. G., Kim, H., Yang, S. H., Na, I. I., Lee, H., Kang, H. J."Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study". Oncology Letters 27.5 (2024): 211.
Chicago
Jang, Y. J., Jeong, H. K., Kong, C., Song, W. S., Cho, W. H., Jeon, D. G., Kim, H., Yang, S. H., Na, I. I., Lee, H., Kang, H. J."Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study". Oncology Letters 27, no. 5 (2024): 211. https://doi.org/10.3892/ol.2024.14344
Copy and paste a formatted citation
x
Spandidos Publications style
Jang YJ, Jeong HK, Kong C, Song WS, Cho WH, Jeon DG, Kim H, Yang SH, Na II, Lee H, Lee H, et al: Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study. Oncol Lett 27: 211, 2024.
APA
Jang, Y.J., Jeong, H.K., Kong, C., Song, W.S., Cho, W.H., Jeon, D.G. ... Kang, H.J. (2024). Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study. Oncology Letters, 27, 211. https://doi.org/10.3892/ol.2024.14344
MLA
Jang, Y. J., Jeong, H. K., Kong, C., Song, W. S., Cho, W. H., Jeon, D. G., Kim, H., Yang, S. H., Na, I. I., Lee, H., Kang, H. J."Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study". Oncology Letters 27.5 (2024): 211.
Chicago
Jang, Y. J., Jeong, H. K., Kong, C., Song, W. S., Cho, W. H., Jeon, D. G., Kim, H., Yang, S. H., Na, I. I., Lee, H., Kang, H. J."Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study". Oncology Letters 27, no. 5 (2024): 211. https://doi.org/10.3892/ol.2024.14344
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