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Case Report Open Access

Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report

  • Authors:
    • Xiaolei Wang
    • Jin Song
    • Ling Hu
    • Guanying Ren
    • Nan Geng
    • Zizheng Song
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, Hebei 071000, P.R. China, Department of Respiratory Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 217
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    Published online on: March 21, 2024
       https://doi.org/10.3892/ol.2024.14351
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Abstract

Chemotherapy based on intrapleural perfusion hyperthermia (IPH) can markedly improve the sensitivity of lung adenocarcinoma cells to anti‑programmed cell death receptor 1 (PD1) antibody adjuvant chemotherapy and enhance the clinical response of a patient. In the present study, a unique case of a patient who failed to respond to immunotherapy combined with chemotherapy but achieved prolonged stable disease after treatment with IPH and subsequent sintilimab‑based treatment, is reported. A 50‑year‑old Chinese female patient was admitted to a regional cancer hospital presenting with hemoptysis and persistent fever. The findings of computed tomography imaging and thoracic puncture tissue biopsy indicated a diagnosis of adenocarcinoma. The TNM and clinical stage were identified as cT2N3M0 and stage IIIB, respectively. Immunohistochemical tests showed the expression of programmed death‑ligand 1 (PD‑L1) with a tumor proportion score of 2%. No other classic genetic alterations were detected. Initially, sintilimab‑based chemotherapy at 200 mg was administered, for three cycles from April 2020, and increased pleural effusion was observed on the left side. The best overall response (BOR) assessment of the local lesion was progressive disease. IPH combined with chemotherapy was then carried out from August to September 2020, after which the same course of sintilimab‑based chemotherapy as aforementioned was provided from October 2020 to September 2023. The BOR evaluation results during the monotherapy courses were all judged as stable disease. Therefore, it was concluded that IPH can substantially improve the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Song J, Hu L, Ren G, Geng N and Song Z: Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report. Oncol Lett 27: 217, 2024.
APA
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., & Song, Z. (2024). Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report. Oncology Letters, 27, 217. https://doi.org/10.3892/ol.2024.14351
MLA
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., Song, Z."Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report". Oncology Letters 27.5 (2024): 217.
Chicago
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., Song, Z."Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report". Oncology Letters 27, no. 5 (2024): 217. https://doi.org/10.3892/ol.2024.14351
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Song J, Hu L, Ren G, Geng N and Song Z: Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report. Oncol Lett 27: 217, 2024.
APA
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., & Song, Z. (2024). Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report. Oncology Letters, 27, 217. https://doi.org/10.3892/ol.2024.14351
MLA
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., Song, Z."Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report". Oncology Letters 27.5 (2024): 217.
Chicago
Wang, X., Song, J., Hu, L., Ren, G., Geng, N., Song, Z."Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report". Oncology Letters 27, no. 5 (2024): 217. https://doi.org/10.3892/ol.2024.14351
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