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Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer

  • Authors:
    • Kenji Makita
    • Yasushi Hamamoto
    • Hiromitsu Kanzaki
    • Kei Nagasaki
    • Kenjiro Aogi
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan, Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan
    Copyright: © Makita et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 218
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    Published online on: March 21, 2024
       https://doi.org/10.3892/ol.2024.14352
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Abstract

The clinical significance of mild internal mammary node (IMN) enlargement (Mild‑IMN) is uncertain. This study aimed to evaluate the relationship between treatment outcomes and IMN status in patients with breast cancer who underwent postmastectomy radiation therapy between January 2010 and December 2018. Overall, 250 patients were categorized based on IMN status: Clinically normal IMN (Normal‑IMN; n=172), Mild‑IMN (n=39) and clinically metastatic IMN (cMet‑IMN; n=39). None of the patients in the Normal‑ or Mild‑IMN groups received IMN irradiation. In the cMet‑IMN group, 25 patients underwent IMN irradiation with an IMN boost (10 Gy in 5 fractions), while 14 patients did not. The median follow‑up time was 80.0 months (range, 7.2‑147.6 months). The 7‑year overall survival (OS), disease‑free survival (DFS) and IMN recurrence‑free survival (IRF) rates were 80.2, 73.0 and 93.4%, respectively. Multivariate analyses indicated that only cMet‑IMN had a significant impact on OS [hazard ratio (HR), 1.66; 95% CI, 1.01‑3.68; P=0.05] and DFS (HR, 1.91; 95% CI, 1.08‑3.39; P=0.03), while cMet‑IMN did not have a significant impact on IRF (HR, 1.66; 95% CI, 0.41‑6.78; P=0.48). Additionally, receiving an IMN boost had no influence on OS (HR, 1.11; 95% CI, 0.37‑2.34; P=0.84), DFS (HR, 1.28; 95% CI, 0.51‑3.22; P=0.60) or IRF (HR, 1.94; 95% CI, 0.22‑17.47; P=0.55). In conclusion, the impact of Mild‑IMN on clinical outcomes was small. Although irradiation for cMet‑IMN is important, the impact of the cMet‑IMN boost with 10 Gy in 5 fractions on clinical outcomes may also be limited.
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Copy and paste a formatted citation
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Nagasaki K and Aogi K: Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer. Oncol Lett 27: 218, 2024.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., & Aogi, K. (2024). Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer. Oncology Letters, 27, 218. https://doi.org/10.3892/ol.2024.14352
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Aogi, K."Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer". Oncology Letters 27.5 (2024): 218.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Aogi, K."Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer". Oncology Letters 27, no. 5 (2024): 218. https://doi.org/10.3892/ol.2024.14352
Copy and paste a formatted citation
x
Spandidos Publications style
Makita K, Hamamoto Y, Kanzaki H, Nagasaki K and Aogi K: Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer. Oncol Lett 27: 218, 2024.
APA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., & Aogi, K. (2024). Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer. Oncology Letters, 27, 218. https://doi.org/10.3892/ol.2024.14352
MLA
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Aogi, K."Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer". Oncology Letters 27.5 (2024): 218.
Chicago
Makita, K., Hamamoto, Y., Kanzaki, H., Nagasaki, K., Aogi, K."Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer". Oncology Letters 27, no. 5 (2024): 218. https://doi.org/10.3892/ol.2024.14352
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