Successful treatment of severe splenic lymphoma‑associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report

Masui,Hideyuki; Shindo,Maki; Inoue,Yuta; Sugiyama,Maki; Ueda,Atsushi; Shindo,Takero; Okoshi,Kae; Kinoshita,Koichi

doi:10.3892/ol.2024.14355

Successful treatment of severe splenic lymphoma‑associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report

Authors:
- Hideyuki Masui
- Maki Shindo
- Yuta Inoue
- Maki Sugiyama
- Atsushi Ueda
- Takero Shindo
- Kae Okoshi
- Koichi Kinoshita
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Affiliations: Department of Surgery, Japan Baptist Hospital, Kyoto 606‑8273, Japan, Department of Hematology, Japan Baptist Hospital, Kyoto 606‑8273, Japan, Department of Hematology, Kyoto University Hospital, Kyoto 606‑8397, Japan
Published online on: March 22, 2024 https://doi.org/10.3892/ol.2024.14355
Article Number: 222
Copyright: © Masui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hemophagocytic lymphohistiocytosis (HLH) represents a fatal immunopathology derived from excessive inflammatory reactions. In particular, lymphoma‑associated hemophagocytic syndrome (LAHS) is associated with a dismal prognosis. The current study presented a challenging case of splenic LAHS. A 71‑year‑old man presented with fatigue and anorexia. Laboratory test results revealed anemia, thrombocytopenia, lactate dehydrogenase elevation and markedly elevated levels of ferritin (6,210 ng/ml) and soluble interleukin 2 receptor (sIL‑2R; 11,328 U/ml). Abdominal computed tomography revealed marked splenomegaly, while fluorodeoxyglucose positron emission tomography revealed increased tracer uptake in the spleen. An elective splenectomy was performed, which led to the diagnosis of B‑cell splenic lymphoma with transformation from indolent to aggressive lymphoma. Prior to the splenectomy, thrombocytopenia and hepatic dysfunction with rapidly progressing jaundice appeared, accompanying further elevation of ferritin (25,197 ng/ml) and sIL‑2R levels (30,420 U/ml). On postoperative day 5, the patient was transferred to a tertiary care institution and corticosteroid pulse therapy was immediately initiated after establishing the diagnosis of LAHS. Liver dysfunction gradually recovered and subsequent chemotherapy resulted in complete remission with improved performance status. At eight months after the onset, the patient remains alive without any signs of residual lymphoma. Although splenic lymphoma typically manifests with low‑grade lymphoma, it can transform into high‑grade lymphoma associated with severe complications, such as HLH and multiple organ failure. In this case, splenectomy assisted in not only establishing the diagnosis but also in tumor cytoreduction before commencing chemotherapy. Through interdisciplinary collaboration, the patient was successfully treated by performing a timely splenectomy, followed by steroid pulse therapy and chemotherapy.

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