Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2024 Volume 27 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
Article Open Access

Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging

  • Authors:
    • Yung-Chia Kuo
    • Chi-Hsi Chuang
    • Hsuan-Chih Kuo
    • Cheng-Tao Lin
    • Angel Chao
    • Huei-Jean Huang
    • Hung-Ming Wang
    • Jason Chia‑Hsun Hsieh
    • Hung-Hsueh Chou
  • View Affiliations / Copyright

    Affiliations: Division of Hematology‑Oncology, Department of Internal Medicine, New Taipei Municipal Tucheng Hospital, New Taipei City 236, Taiwan, R.O.C., Department of Pediatrics, New Taipei Municipal TuCheng Hospital, New Taipei City 236, Taiwan, R.O.C., Department and College of Medicine, Chang Gung University, Taoyuan 333, Taiwan, R.O.C., Division of Hematology‑Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan, R.O.C., Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan, R.O.C.
    Copyright: © Kuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 234
    |
    Published online on: March 26, 2024
       https://doi.org/10.3892/ol.2024.14367
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Current tools are insufficient for distinguishing patients with ovarian cancer from those with benign ovarian lesions before extensive surgery. The present study utilized a readily accessible platform employing a negative selection strategy, followed by flow cytometry, to enumerate circulating tumor cells (CTCs) in patients with ovarian cancer. These counts were compared with those from patients with benign ovarian lesions. CTC counts at baseline, before and after anticancer therapy, and across various clinical scenarios involving ovarian lesions were assessed. A negative‑selection protocol we proposed was applied to patients with suspected ovarian cancer and prospectively utilized in those subsequently confirmed to have malignancy. The protocol was implemented before anticancer therapy and at months 3, 6, 9 and 12 post‑treatment. A cut‑off value for CTC number at 4.75 cells/ml was established to distinguish ovarian malignancy from benign lesions, with an area under the curve of 0.900 (P<0.001). In patients with ovarian cancer, multivariate Cox regression analysis revealed that baseline CTC counts and the decline in CTCs within the first three months post‑therapy were significant predictors of prolonged progression‑free survival. Additionally, baseline CTC counts independently prognosticated overall survival. CTC counts obtained with the proposed platform, used in the present study, suggest that pre‑operative CTC testing may be able to differentiate between malignant and benign tumors. Moreover, CTC counts may indicate oncologic outcomes in patients with ovarian cancer who have undergone cancer therapies.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A and Bray F: Cancer statistics for the year 2020: An overview. Int J Cancer. 149:778–789. 2021. View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Cancer registry annual report, 2021 Taiwan, Department of Health, Executive Yuan. https://www.hpa.gov.tw/File/Attach/17639/File_23506.pdfFebruary 25–2024

4 

NCCN, . The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). 2024.version 1.0.https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1453Febuary 25–2024

5 

Burger RA, Brady MF, Bookman MA, Fleming GF, Monk BJ, Huang H, Mannel RS, Homesley HD, Fowler J, Greer BE, et al: Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med. 365:2473–2483. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Moore K, Colombo N, Scambia G, Kim BG, Oaknin A, Friedlander M, Lisyanskaya A, Floquet A, Leary A, Sonke GS, et al: Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer. N Engl J Med. 379:2495–2505. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C and Vergote I: Ovarian cancer. Crit Rev Oncol Hematol. 60:159–179. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Cancer Stat Facts. Ovarian Cancer. 2020.Available at. https://seer.cancer.gov/statfacts/html/ovary.htmlOctober 10–2023

9 

Yeung TL, Leung CS, Yip KP, Au Yeung CL, Wong ST and Mok SC: Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and molecular processes in cancer metastasis. Am J Physiol Cell Physiol. 309:C444–C456. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Tuxen MK, Sölétormos G and Dombernowsky P: Tumor markers in the management of patients with ovarian cancer. Cancer Treat Rev. 21:215–245. 1995. View Article : Google Scholar : PubMed/NCBI

11 

Qing X, Liu L and Mao X: A Clinical diagnostic value analysis of serum CA125, CA199, and HE4 in Women with early ovarian cancer: Systematic review and meta-analysis. Comput Math Methods Med. 2022:93393252022. View Article : Google Scholar : PubMed/NCBI

12 

Moore LE, Fung ET, McGuire M, Rabkin CC, Molinaro A, Wang Z, Zhang F, Wang J, Yip C, Meng XY and Pfeiffer RM: Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population. Cancer Epidemiol Biomarkers Prev. 15:1641–1646. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Schweigert FJ and Sehouli J: Transthyretin, a biomarker for nutritional status and ovarian cancer. Cancer Res. 65:11142005. View Article : Google Scholar : PubMed/NCBI

14 

Macuks R, Baidekalna I, Gritcina J, Avdejeva A and Donina S: Apolipoprotein A1 and transferrin as biomarkers in ovarian cancer diagnostics. Acta Chirurgica Latviensis. 10:16–20. 2010. View Article : Google Scholar

15 

Giampaolino P, Foreste V, Della Corte L, Di Filippo C, Iorio G and Bifulco G: Role of biomarkers for early detection of ovarian cancer recurrence. Gland Surg. 9:1102–1111. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Yang WL, Lu Z and Bast RC Jr: The role of biomarkers in the management of epithelial ovarian cancer. Expert Rev Mol Diagn. 17:577–591. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Muinao T, Deka Boruah HP and Pal M: Diagnostic and Prognostic Biomarkers in ovarian cancer and the potential roles of cancer stem cells-An updated review. Exp Cell Res. 362:1–10. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Zhang F, Zhang Y, Ke C, Li A, Wang W, Yang K, Liu H, Xie H, Deng K, Zhao W, et al: Predicting ovarian cancer recurrence by plasma metabolic profiles before and after surgery. Metabolomics. 14:652018. View Article : Google Scholar : PubMed/NCBI

19 

Ashworth T: A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Aust Med J. 14:1461869.

20 

Yousefi M, Dehghani S, Nosrati R, Ghanei M, Salmaninejad A, Rajaie S, Hasanzadeh M and Pasdar A: Current insights into the metastasis of epithelial ovarian cancer-hopes and hurdles. Cell Oncol. 43:515–538. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Coffman LG, Burgos-Ojeda D, Wu R, Cho K, Bai S and Buckanovich RJ: New models of hematogenous ovarian cancer metastasis demonstrate preferential spread to the ovary and a requirement for the ovary for abdominal dissemination. Transl Res. 175:92–102.e2. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Joosse SA, Gorges TM and Pantel K: Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med. 7:1–11. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Giannopoulou L, Kasimir-Bauer S and Lianidou ES: Liquid biopsy in ovarian cancer: Recent advances on circulating tumor cells and circulating tumor DNA. Clin Chem Lab Med. 56:186–197. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, et al: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 339:580–584. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Fan T, Zhao Q, Chen JJ, Chen WT and Pearl ML: Clinical significance of circulating tumor cells detected by an invasion assay in peripheral blood of patients with ovarian cancer. Gynecol Oncol. 112:185–191. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Van der Auwera I, Peeters D, Benoy IH, Elst HJ, Van Laere SJ, Prové A, Maes H, Huget P, van Dam P, Vermeulen PB and Dirix LY: Circulating tumour cell detection: A direct comparison between the CellSearch System, the AdnaTest and CK-19/mammaglobin RT-PCR in patients with metastatic breast cancer. Br J Cancer. 102:276–284. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Su PJ, Wu MH, Wang HM, Lee CL, Huang WK, Wu CE, Chang HK, Chao YK, Tseng CK, Chiu TK, et al: Circulating tumour cells as an independent prognostic factor in patients with advanced oesophageal squamous cell carcinoma undergoing chemoradiotherapy. Sci Rep. 6:314232016. View Article : Google Scholar : PubMed/NCBI

28 

Bankó P, Lee SY, Nagygyörgy V, Zrínyi M, Chae CH, Cho DH and Telekes A: Technologies for circulating tumor cell separation from whole blood. J Hematol Oncol. 12:482019. View Article : Google Scholar : PubMed/NCBI

29 

Chu PY, Hsieh CH and Wu MH: The Combination of immunomagnetic bead-based cell isolation and optically induced dielectrophoresis (ODEP)-based microfluidic device for the negative selection-based isolation of circulating tumor cells (CTCs). Front Bioeng Biotechnol. 8:9212020. View Article : Google Scholar : PubMed/NCBI

30 

Hsieh JCH and Wu TMH: The selection strategy for circulating tumor cells (CTCs) isolation and enumeration: Technical features methods, and clinical applications. IntechOpen London. 2016.

31 

Li SH, Wu MH, Wang HM, Hsu PC, Fang YF, Wang CL, Chu HC, Lin HC, Lee LY, Wu CY, et al: Circulating EGFR mutations in patients with lung adenocarcinoma by circulating tumor cell isolation systems: A concordance study. Int J Mol Sci. 23:106612022. View Article : Google Scholar : PubMed/NCBI

32 

Sauerbrei W, Taube SE, McShane LM, Cavenagh MM and Altman DG: Reporting recommendations for tumor marker prognostic studies (REMARK): An abridged explanation and elaboration. J Natl Cancer Inst. 110:803–811. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Wu CY, Fu JY, Wu CF, Hsieh MJ, Liu YH, Liu HP, Hsieh JC and Peng YT: Malignancy prediction capacity and possible prediction model of circulating tumor cells for suspicious pulmonary lesions. J Pers Med. 11:4442021. View Article : Google Scholar : PubMed/NCBI

34 

Gao X, Leow OQY, Chiu CH, Hou MM, Hsieh JCH and Chao YK: Clinical utility of circulating tumor cells for predicting major histopathological response after neoadjuvant chemoradiotherapy in patients with esophageal cancer. J Pers Med. 12:14402022. View Article : Google Scholar : PubMed/NCBI

35 

Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, Meyer L, Gress DM, Byrd DR and Winchester DP: The eighth edition AJCC cancer staging manual: Continuing to build a bridge from a population-based to a more ‘personalized’ approach to cancer staging. CA Cancer J Clin. 67:93–99. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Berek JS, Renz M, Kehoe S, Kumar L and Friedlander M: Cancer of the ovary, fallopian tube, and peritoneum: 2021 update. Int J Gynaecol Obstet. 155 (Suppl 1):S61–S85. 2021. View Article : Google Scholar

37 

Zuo L, Li X, Zhu H, Li A and Wang Y: Expression of mir-181a in circulating tumor cells of ovarian cancer and its clinical application. ACS Omega. 6:22011–22019. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Obermayr E, Reiner A, Brandt B, Braicu EI, Reinthaller A, Loverix L, Concin N, Woelber L, Mahner S, Sehouli J, et al: The long-term prognostic significance of circulating tumor cells in ovarian cancer-A study of the OVCAD consortium. Cancers. 13:26132021. View Article : Google Scholar : PubMed/NCBI

39 

Obermayr E, Braicu EI, Polterauer S, Loverix L, Concin N, Woelber L, Mahner S, Sehouli J, Van Gorp T, Vergote I, et al: Association of a combined cancer exhaustion score with circulating tumor cells and outcome in ovarian cancer-a study of the OVCAD consortium. Cancers. 13:58652021. View Article : Google Scholar : PubMed/NCBI

40 

Kolostova K, Pinkas M, Jakabova A, Pospisilova E, Svobodova P, Spicka J, Cegan M, Matkowski R and Bobek V: Molecular characterization of circulating tumor cells in ovarian cancer. Am J Cancer Res. 6:9732016.PubMed/NCBI

41 

Lee M, Kim EJ, Cho Y, Kim S, Chung HH, Park NH and Song YS: Predictive value of circulating tumor cells (CTCs) captured by microfluidic device in patients with epithelial ovarian cancer. Gynecol Oncol. 145:361–365. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Suh DH, Kim M, Choi JY, Bu J, Kang YT, Kwon BS, Lee B, Kim K, No JH, Kim YB and Cho YH: Circulating tumor cells in the differential diagnosis of adnexal masses. Oncotarget. 8:771952017. View Article : Google Scholar : PubMed/NCBI

43 

Kim M, Suh DH, Choi JY, Bu J, Kang YT, Kim K, No JH, Kim YB and Cho YH: Post-debulking circulating tumor cell as a poor prognostic marker in advanced stage ovarian cancer: A prospective observational study. Medicine (Baltimore). 98:e153542019. View Article : Google Scholar : PubMed/NCBI

44 

Kim H, Lim M, Kim JY, Shin SJ, Cho YK and Cho CH: Circulating tumor cells enumerated by a centrifugal microfluidic device as a predictive marker for monitoring ovarian cancer treatment: A pilot study. Diagnostics. 10:2492020. View Article : Google Scholar : PubMed/NCBI

45 

Lou E, Vogel RI, Teoh D, Hoostal S, Grad A, Gerber M, Monu M, Lukaszewski T, Deshpande J, Linden MA and Geller MA: Assessment of circulating tumor cells as a predictive biomarker of histology in women with suspected ovarian cancer. Lab Med. 49:134–139. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Banys-Paluchowski M, Fehm T, Neubauer H, Paluchowski P, Krawczyk N, Meier-Stiegen F, Wallach C, Kaczerowsky A and Gebauer G: Clinical relevance of circulating tumor cells in ovarian, fallopian tube and peritoneal cancer. Arch Gynecol Obstet. 301:1027–1035. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Pearl ML, Dong H, Tulley S, Zhao Q, Golightly M, Zucker S and Chen WT: Treatment monitoring of patients with epithelial ovarian cancer using invasive circulating tumor cells (iCTCs). Gynecol Oncol. 137:229–238. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Gening SO, Abakumova TV, Gafurbaeva DU, Rizvanov AA, Antoneeva II, Miftakhova RR, Peskov AB and Gening TP: The detection of stem-like circulating tumor cells could increase the clinical applicability of liquid biopsy in ovarian cancer. Life (Basel). 11:8152021.PubMed/NCBI

49 

Guo YX, Neoh KH, Chang XH, Sun Y, Cheng HY, Ye X, Ma RQ, Han RPS and Cui H: Diagnostic value of HE4+ circulating tumor cells in patients with suspicious ovarian cancer. Oncotarget. 9:75222018. View Article : Google Scholar : PubMed/NCBI

50 

Luo HJ, Hu ZD, Cui M, Zhang XF, Tian WY, Ma CQ, Ren YN and Dong ZL: Diagnostic performance of CA125, HE4, ROMA, and CPH-I in identifying primary ovarian cancer. J Obstet Gynaecol Res. 49:998–1006. 2023. View Article : Google Scholar : PubMed/NCBI

51 

Chan HT, Chin YM, Nakamura Y and Low SK: Clonal hematopoiesis in liquid biopsy: From biological noise to valuable clinical implications. Cancers (Basel). 12:22772020. View Article : Google Scholar : PubMed/NCBI

52 

Alix-Panabières C and Pantel K: Circulating tumor cells: Liquid biopsy of cancer. Clin Chem. 59:110–118. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Asante DB, Calapre L, Ziman M, Meniawy TM and Gray ES: Liquid biopsy in ovarian cancer using circulating tumor DNA and cells: Ready for prime time? Cancer Lett. 468:59–71. 2020. View Article : Google Scholar : PubMed/NCBI

54 

Diamantopoulou Z, Castro-Giner F and Aceto N: Circulating tumor cells: Ready for translation? J Exp Med. 217:e202003562020. View Article : Google Scholar : PubMed/NCBI

55 

Lin D, Shen L, Luo M, Zhang K, Li J, Yang Q, Zhu F, Zhou D, Zheng S, Chen Y and Zhou J: Circulating tumor cells: Biology and clinical significance. Signal Transduct Target Ther. 6:4042021. View Article : Google Scholar : PubMed/NCBI

56 

Palladini G, Paiva B, Wechalekar A, Massa M, Milani P, Lasa M, Ravichandran S, Krsnik I, Basset M, Burgos L, et al: Minimal residual disease negativity by next-generation flow cytometry is associated with improved organ response in AL amyloidosis. Blood Cancer J. 11:342021. View Article : Google Scholar : PubMed/NCBI

57 

Nguyen TNA, Huang PS, Chu PY, Hsieh CH and Wu MH: Recent progress in enhanced cancer diagnosis, prognosis, and monitoring using a combined analysis of the number of circulating tumor cells (CTCs) and other clinical parameters. Cancers (Basel). 15:53722023. View Article : Google Scholar : PubMed/NCBI

58 

Asante DB, Mohan G, Acheampong E, Ziman M, Calapre L, Meniawy TM, Gray ES and Beasley AB: Genetic analysis of heterogeneous subsets of circulating tumour cells from high grade serous ovarian carcinoma patients. Sci Rep. 13:25522023. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kuo Y, Chuang C, Kuo H, Lin C, Chao A, Huang H, Wang H, Hsieh JC and Chou H: Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging. Oncol Lett 27: 234, 2024.
APA
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H. ... Chou, H. (2024). Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging. Oncology Letters, 27, 234. https://doi.org/10.3892/ol.2024.14367
MLA
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H., Wang, H., Hsieh, J. C., Chou, H."Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging". Oncology Letters 27.5 (2024): 234.
Chicago
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H., Wang, H., Hsieh, J. C., Chou, H."Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging". Oncology Letters 27, no. 5 (2024): 234. https://doi.org/10.3892/ol.2024.14367
Copy and paste a formatted citation
x
Spandidos Publications style
Kuo Y, Chuang C, Kuo H, Lin C, Chao A, Huang H, Wang H, Hsieh JC and Chou H: Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging. Oncol Lett 27: 234, 2024.
APA
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H. ... Chou, H. (2024). Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging. Oncology Letters, 27, 234. https://doi.org/10.3892/ol.2024.14367
MLA
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H., Wang, H., Hsieh, J. C., Chou, H."Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging". Oncology Letters 27.5 (2024): 234.
Chicago
Kuo, Y., Chuang, C., Kuo, H., Lin, C., Chao, A., Huang, H., Wang, H., Hsieh, J. C., Chou, H."Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging". Oncology Letters 27, no. 5 (2024): 234. https://doi.org/10.3892/ol.2024.14367
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team