Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2024 Volume 27 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer

  • Authors:
    • Ercan Pulat
    • Mehmet R. Topçul
  • View Affiliations / Copyright

    Affiliations: Department of Biology, Faculty of Science, Istanbul University, Istanbul 34134, Türkiye
  • Article Number: 243
    |
    Published online on: April 3, 2024
       https://doi.org/10.3892/ol.2024.14376
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, antiproliferative and anticancer effects of Valamor (VLM), which contains the active component ribociclib, and DPQ, a poly(ADP‑ribose) polymerase 1 inhibitor, alone and in combination were evaluated in the MCF‑7 and MDA‑MB‑231 breast cancer cell lines in vitro. VLM was applied at concentrations of 40, 80 and 160 µg/ml, and DPQ was used at concentrations of 3, 6 and 9 µg/ml. The proliferation rate, cell index obtained from the real‑time cell analysis system, mitosis activity, bromodeoxyuridine cell proliferation and caspase activity parameters were determined. In conclusion, the results obtained from cell kinetics parameters demonstrated the anticancer and antiproliferative effects of the combination of VLM and DPQ on breast cancer cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Veronesi U, Boyle P, Goldhirsch A, Orecchia R and Viale G: Breast cancer. Lancet. 365:1727–1741. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Cliffton EE and Young LE: Carcinoma of the breast; five to twenty-year follow-up following radical mastectomy. Am J Surg. 82:185–190. 1951. View Article : Google Scholar : PubMed/NCBI

6 

Figueiredo MI, Cullen J, Hwang YT, Rowland JH and Mandelblatt JS: Breast cancer treatment in older women: Does getting what you want improve your long-term body image and mental health? J Clin Oncol. 22:4002–4009. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Mathews FS: The ten-year survivors of radical mastectomy. Ann Surg. 98:635–643. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Nagarajan D and McArdle SEB: Immune landscape of breast cancers. Biomedicines. 6:202018. View Article : Google Scholar : PubMed/NCBI

9 

Makhoul I, Atiq M, Alwbari A and Kieber-Emmons T: Breast cancer immunotherapy: An update. Breast Cancer (Auckl). 12:11782234187748022018.PubMed/NCBI

10 

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y and Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Investig. 121:2750–2767. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Liedtke C, Mazouni C, Hess KR, André F, Tordai A, Mejia JA, Symmans WF, Gonzalez-Angulo AM, Hennessy B, Green M, et al: Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J Clin Oncol. 26:1275–1281. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Chen X, Xu D, Li X, Zhang J, Xu W, Hou J, Zhang W and Tang J: Latest overview of the cyclindependent kinases 4/6 inhibitors in breast cancer: The past, the present, and the future. J Cancer. 10:6608–6617. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Hulka BS: Epidemiology of susceptibility to breast cancer. Prog Clin Biol Res. 395:159–174. 1996.PubMed/NCBI

14 

Reinert T and Barrios CH: Optimal management of hormone receptor positive metastatic breast cancer in 2016. Ther Adv Med Oncol. 7:304–320. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Wuerstlein R and Harbeck N: Neoadjuvant therapy for HER2-positive breast cancer. Rev Recent Clin Trials. 12:81–92. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Riggi N, Aguet M and Stamenkovic I: Cancer metastasis: A reappraisal of its underlying mechanisms and their relevance to treatment. Annu Rev Pathol. 13:117–140. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Scully OJ, Bay BH, Yip G and Yu Y: Breast cancer metastasis. Cancer Genomics Proteomics. 9:311–320. 2012.PubMed/NCBI

19 

Poratti M and Marzaro G: Third-generation CDK inhibitors: A review on the synthesis and binding modes of palbociclib, ribociclib, and abemaciclib. Eur J Med Chem. 172:143–153. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Luo X and Kraus WL: A one and a two … expanding roles for poly(ADP-ribose) polymerases in metabolism. Cell Metab. 13:353–355. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zhou D, Chu W, Xu J, Jones LA, Peng X, Li S, Chen DL and Mach RH: Synthesis, [18F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography. Bioorg Med Chem Lett. 22:1700–1707. 2014. View Article : Google Scholar

22 

Giannini G, Battistuzzi G, Vesci L, Milazzo FM, Paolis FD, Barbarino M, Guglielmi MB, Carollo V, Gallo G, Artali R and Dallavalle S: Novel PARP-1 inhibitors based on a 2-propanoyl-3H-quinazolin-4-one scaffold. Bioorg Med Chem Lett. 24:462–466. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Berger NA: Poly(ADP-ribose) in the cellular response to DNA damage. Radiat Res. 101:4–15. 1985. View Article : Google Scholar : PubMed/NCBI

24 

Topçul M, Çeti N İL, Özbaş Turan S and Kolusayin Ozar MÖ: In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab-paclitaxel on triple-negative and luminal A breast cancer cells. Oncol Rep. 40:527–535. 2018.PubMed/NCBI

25 

Silberholz J, Bertsimas D and Vahdat L: Clinical benefit, toxicity and cost of metastatic breast cancer therapies: Systematic review and meta-analysis. Breast Cancer Res Treat. 176:535–543. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Malumbres M and Barbacid M: Cell cycle, CDKs, and cancer: A changing paradigm. Nat Rev Cancer. 9:153–166. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Sherr CJ, Beach D and Shapiro GI: Targeting CDK4 and CDK6: From discovery to therapy. Cancer Discov. 6:353–367. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Xiong Y, Menninger J, Beach D and Ward DC: Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics. 13:575–584. 1992. View Article : Google Scholar : PubMed/NCBI

30 

Braal CL, Jongbloed EM, Wilting SM, Mathijssen RHJ, Koolen SLW and Jager A: Inhibiting CDK4/6 in breast cancer with palbociclib, ribociclib, and abemaciclib: Similarities and differences. Drugs. 81:317–331. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, et al: Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer. Ann Oncol. 29:1541–1547. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Slamon DJ, Neven P, Chia S, Fasching PA, De Laurentiis M, Im SA, Petrakova K, Bianchi GV, Esteva FJ, Martín M, et al: Phase III randomized study of ribociclib and fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: MONALEESA-3. J Clin Oncol. 36:2465–2472. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Tripathy D, Im SA, Colleoni M, Franke F, Bardia A, Harbeck N, Hurvitz SA, Chow L, Sohn J, Lee KS, et al: Ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (MONALEESA-7): A randomised phase 3 trial. Lancet Oncol. 19:904–915. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Fang H, Huang D, Yang F and Guan X: Potential biomarkers of CDK4/6 inhibitors in hormone receptor-positive advanced breast cancer. Breast Cancer Res Treat. 168:287–297. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Cortesi L, Rugo HS and Jackisch C: An overview of PARP ınhibitors for the treatment of breast cancer. Target Oncol. 16:255–282. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Eek D, Krohe M, Mazar I, Horsfeld A, Pompilus F, Friebe R and Shields AL: Patient-reported preferences for oral versus intravenous administration for the treatment of cancer: A review of the literature. Patient Prefer Adherence. 10:1609–1621. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Tomimatsu N, Mukherjee B, Catherine Hardebeck M, Ilcheva M, Vanessa Camacho C, Louise Harris J, Porteus M, Llorente B, Khanna KK and Burma S: Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nat Commun. 5:35612014. View Article : Google Scholar : PubMed/NCBI

38 

Bajrami I, Frankum JR, Konde A, Miller RE, Rehman FL, Brough R, Campbell J, Sims D, Rafiq R, Hooper S, et al: Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Cancer Res. 74:287–297. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Joshi PM, Sutor SL, Huntoon CJ and Karnitz LM: Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors. J Biol Chem. 289:9247–9253. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, et al: CDK12 ınhibition reverses de novo and acquired PARP inhibitor resistance in BRCA wild-type and mutated models of triple-negative breast cancer. Cell Rep. 17:2367–2381. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H and Rabkin SD: Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 10:29102019. View Article : Google Scholar : PubMed/NCBI

42 

Militello AM, Zielli T, Boggiani D, Michiara M, Naldi N, Bortesi B, Zanelli P, Uliana V, Giuliotti S and Musolino A: Mechanism of action and clinical efficacy of CDK4/6 inhibitors in BRCA-mutated, estrogen receptor-positive breast cancers: Case report and literature review. Front Oncol. 9:7592019. View Article : Google Scholar : PubMed/NCBI

43 

Carey JPW, Karakas C, Bui T, Chen X, Vijayaraghavan S, Zhao Y, Wang J, Mikule K, Litton JK, Hunt KK and Keyomarsi K: Synthetic lethality of PARP inhibitors in combination with MYC blockade is independent of BRCA status in triple-negative breast Cancer. Cancer Res. 78:742–757. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Li S, Zhang Y, Wang N, Guo R, Liu Q, Lv C, Wang J, Wang L and Yang Q: Pan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells. Cell Death Dis. 11:2192020. View Article : Google Scholar : PubMed/NCBI

45 

Eskiler GG, Ozman Z, Haciefendi A and Cansaran-Duman D: Novel combination treatment of CDK 4/6 inhibitors with PARP inhibitors in triple negative breast cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 396:1031–1041. 2023. View Article : Google Scholar : PubMed/NCBI

46 

Li H, Liu ZY, Wu N, Chen YC, Cheng Q and Wang J: PARP inhibitor resistance: The underlying mechanisms and clinical implications. Mol Cancer. 19:1072020. View Article : Google Scholar : PubMed/NCBI

47 

Klein FG, Granier C, Zhao Y, Pan Q, Tong Z, Gschwend JE, Holm PS and Nawroth R: Combination of talazoparib and palbociclib as a potent treatment strategy in bladder cancer. J Pers Med. 11:3402021. View Article : Google Scholar : PubMed/NCBI

48 

Zhu X, Chen L, Huang B, Li X, Yang L, Hu X, Jiang Y, Shao Z and Wang Z: Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancer. J Exp Clin Cancer Res. 40:1222021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pulat E and Topçul MR: Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncol Lett 27: 243, 2024.
APA
Pulat, E., & Topçul, M.R. (2024). Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncology Letters, 27, 243. https://doi.org/10.3892/ol.2024.14376
MLA
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27.6 (2024): 243.
Chicago
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27, no. 6 (2024): 243. https://doi.org/10.3892/ol.2024.14376
Copy and paste a formatted citation
x
Spandidos Publications style
Pulat E and Topçul MR: Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncol Lett 27: 243, 2024.
APA
Pulat, E., & Topçul, M.R. (2024). Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer. Oncology Letters, 27, 243. https://doi.org/10.3892/ol.2024.14376
MLA
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27.6 (2024): 243.
Chicago
Pulat, E., Topçul, M. R."Effects of combined use of ribociclib with PARP1 inhibitor on cell kinetics in breast cancer". Oncology Letters 27, no. 6 (2024): 243. https://doi.org/10.3892/ol.2024.14376
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team