Open Access

Prognostic value of serum tartrate‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer

  • Authors:
    • Masafumi Shimoda
    • Yasufumi Sato
    • Kaori Abe
    • Nanae Masunaga
    • Masami Tsukabe
    • Tetsuhiro Yoshinami
    • Yoshiaki Sota
    • Tomohiro Miyake
    • Tomonori Tanei
    • Kenzo Shimazu
  • View Affiliations

  • Published online on: April 5, 2024     https://doi.org/10.3892/ol.2024.14383
  • Article Number: 250
  • Copyright: © Shimoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bone metastasis significantly affects the quality of life of patients with metastatic breast cancer, and can shorten overall survival. Identifying patients with early‑stage breast cancer at high risk for bone metastasis and preventing bone metastasis may lead to a better quality of life and prolonged survival. The present study investigated whether serum tartrate‑resistant acid phosphatase‑5b (TRACP‑5b), a bone turnover marker, can be a prognostic factor for bone metastasis. Female patients who underwent resectable breast surgery between May 2002 and August 2006 were consecutively investigated. A total of 304 patients with a median follow‑up of 3,722 days were retrospectively analyzed. TRACP‑5b levels in sera prepared from patients' blood drawn preoperatively without any presurgical treatments were measured using an enzyme‑linked immunosorbent assay. The cutoff of TRACP‑5b levels, in order to separate patients into high and low TRACP‑5b groups, was set at median (347 mU/dl). The associations of clinicopathological factors, including TRACP‑5b, with bone metastasis‑free interval (BMFI), which was defined as the duration between surgery and the diagnosis of bone metastasis at any time point, were examined. Multivariate analysis of various clinicopathological features revealed that lymph node metastasis and histological grade were independent factors associated with BMFI (P=0.017 and 0.030, respectively). In patients with node‑positive breast cancer (n=114), a high TRACP‑5b level and a high grade were significantly and independently associated with worse BMFI (log‑rank P=0.041 and 0.011, respectively). In conclusion, these findings indicated that TRACP‑5b may predict bone metastasis in patients with node‑positive breast cancer.
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June-2024
Volume 27 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Shimoda M, Sato Y, Abe K, Masunaga N, Tsukabe M, Yoshinami T, Sota Y, Miyake T, Tanei T, Shimazu K, Shimazu K, et al: Prognostic value of serum tartrate‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer. Oncol Lett 27: 250, 2024
APA
Shimoda, M., Sato, Y., Abe, K., Masunaga, N., Tsukabe, M., Yoshinami, T. ... Shimazu, K. (2024). Prognostic value of serum tartrate‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer. Oncology Letters, 27, 250. https://doi.org/10.3892/ol.2024.14383
MLA
Shimoda, M., Sato, Y., Abe, K., Masunaga, N., Tsukabe, M., Yoshinami, T., Sota, Y., Miyake, T., Tanei, T., Shimazu, K."Prognostic value of serum tartrate‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer". Oncology Letters 27.6 (2024): 250.
Chicago
Shimoda, M., Sato, Y., Abe, K., Masunaga, N., Tsukabe, M., Yoshinami, T., Sota, Y., Miyake, T., Tanei, T., Shimazu, K."Prognostic value of serum tartrate‑resistant acid phosphatase‑5b for bone metastasis in patients with resectable breast cancer". Oncology Letters 27, no. 6 (2024): 250. https://doi.org/10.3892/ol.2024.14383