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Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma

  • Authors:
    • Zhen Su
    • Jie Tang
    • Yan He
    • Wei Hua Zeng
    • Qian Yu
    • Xiao Long Cao
    • Guo Rong Zou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Panyu Central Hospital, Cancer Institute of Panyu, Guangzhou, Guangdong 511400, P.R. China, Department of Oncology, Panyu Central Hospital, Cancer Institute of Panyu, Guangzhou, Guangdong 511400, P.R. China
    Copyright: © Su et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 252
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    Published online on: April 9, 2024
       https://doi.org/10.3892/ol.2024.14385
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Abstract

The pan‑immune‑inflammation‑value (PIV) is a comprehensive biomarker that integrates different peripheral blood cell subsets. The present study aimed to evaluate the prognostic ability of PIV in patients with nasopharyngeal carcinoma (NPC) undergoing chemoradiotherapy. PIV was assessed using the following equation: (Neutrophil count x platelet count x monocyte count)/lymphocyte count. The Kaplan‑Meier method and Cox hazards regression models were used for survival analyses. The optimal cut‑off values for PIV and systemic immune‑inflammation index (SII) were determined using receiver operating characteristic analysis to be 428.0 and 1032.7, respectively. A total of 319 patients were recruited. Patients with a low baseline PIV (≤428.0) accounted for 69.9% (n=223) and patients with a high baseline PIV (>428.0) accounted for 30.1% (n=96). Compared with patients with low PIV, patients with a high PIV had significantly worse 5‑year progression‑free survival [PFS; 66.8 vs. 77.1%; hazard ratio (HR), 1.97; 95% confidence interval (CI), 1.22‑3.23); P=0.005] and 5‑year overall survival (OS; 68.7 vs. 86.9%, HR, 2.71; 95% CI, 1.45‑5.03; P=0.001). PIV was also a significant independent prognostic indicator for OS (HR, 2.19; 95% CI, 1.16‑4.12; P=0.016) and PFS (HR, 1.86; 95% CI, 1.14‑3.04; P=0.013) and outperformed the SII in multivariate analysis. In conclusion, the PIV was a powerful predictor of survival outcomes and outperformed the SII in patients with NPC treated with chemoradiotherapy. Prospective validation of the PIV should be performed to better stratify radical treatment of patients with NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Su Z, Tang J, He Y, Zeng W, Yu Q, Cao X and Zou G: Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma. Oncol Lett 27: 252, 2024.
APA
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., & Zou, G. (2024). Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma. Oncology Letters, 27, 252. https://doi.org/10.3892/ol.2024.14385
MLA
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., Zou, G."Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma". Oncology Letters 27.6 (2024): 252.
Chicago
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., Zou, G."Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma". Oncology Letters 27, no. 6 (2024): 252. https://doi.org/10.3892/ol.2024.14385
Copy and paste a formatted citation
x
Spandidos Publications style
Su Z, Tang J, He Y, Zeng W, Yu Q, Cao X and Zou G: Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma. Oncol Lett 27: 252, 2024.
APA
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., & Zou, G. (2024). Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma. Oncology Letters, 27, 252. https://doi.org/10.3892/ol.2024.14385
MLA
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., Zou, G."Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma". Oncology Letters 27.6 (2024): 252.
Chicago
Su, Z., Tang, J., He, Y., Zeng, W., Yu, Q., Cao, X., Zou, G."Pan‑immune‑inflammation value as a novel prognostic biomarker in nasopharyngeal carcinoma". Oncology Letters 27, no. 6 (2024): 252. https://doi.org/10.3892/ol.2024.14385
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