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Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review)

  • Authors:
    • Zhi Wang
    • Yu Chang
    • Haibo Sun
    • Yuqin Li
    • Tongyu Tang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The First Hospital of Jilin University, Changchun, Jilin 130000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 257
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    Published online on: April 9, 2024
       https://doi.org/10.3892/ol.2024.14390
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Abstract

The link between inflammation and cancer is well documented and colonic inflammation caused by inflammatory bowel disease (IBD) is thought to be a high‑risk factor for the development of colorectal cancer (CRC). The complex crosstalk between epithelial and inflammatory cells is thought to underlie the progression from inflammation to cancer. The present review collates and summarises recent advances in the understanding of the pathogenesis of IBD‑associated CRC (IBD‑CRC), including the oncogenic mechanisms of the main inflammatory signalling pathways and genetic alterations induced by oxidative stress during colonic inflammation, and discusses the crosstalk between the tumour microenvironment, intestinal flora and host immune factors during inflammatory oncogenesis in colitis‑associated CRC. In addition, the therapeutic implications of anti‑inflammatory therapy for IBD‑CRC were discussed, intending to provide new insight into improve clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Chang Y, Sun H, Li Y and Tang T: Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review). Oncol Lett 27: 257, 2024.
APA
Wang, Z., Chang, Y., Sun, H., Li, Y., & Tang, T. (2024). Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review). Oncology Letters, 27, 257. https://doi.org/10.3892/ol.2024.14390
MLA
Wang, Z., Chang, Y., Sun, H., Li, Y., Tang, T."Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review)". Oncology Letters 27.6 (2024): 257.
Chicago
Wang, Z., Chang, Y., Sun, H., Li, Y., Tang, T."Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review)". Oncology Letters 27, no. 6 (2024): 257. https://doi.org/10.3892/ol.2024.14390
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Chang Y, Sun H, Li Y and Tang T: Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review). Oncol Lett 27: 257, 2024.
APA
Wang, Z., Chang, Y., Sun, H., Li, Y., & Tang, T. (2024). Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review). Oncology Letters, 27, 257. https://doi.org/10.3892/ol.2024.14390
MLA
Wang, Z., Chang, Y., Sun, H., Li, Y., Tang, T."Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review)". Oncology Letters 27.6 (2024): 257.
Chicago
Wang, Z., Chang, Y., Sun, H., Li, Y., Tang, T."Advances in molecular mechanisms of inflammatory bowel disease‑associated colorectal cancer (Review)". Oncology Letters 27, no. 6 (2024): 257. https://doi.org/10.3892/ol.2024.14390
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